Cone biopsy of cervix - Rcpa.tv

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Cervical squamous dysplasia • Dysplastic cells are crowded, show nuclear enlargement and hyperchromasia with coarse chromatin • There are increased numbers of suprabasilar mitoses • Atypical koilocytes and dyskeratoses are seen in Human Papilloma Virus infection (HPV)
Cervical squamous dysplasia • CIN I - changes confined to lower (basal) third of epithelium • CIN II - changes confined to lower twothirds of epithelium • CIN III - changes involved full thickness of epithelium
Page 1 and 2: Cone biopsy of cervix. An example o
Page 3 and 4: Terminology • Cervical intraepith
Page 5 and 6: Contents of histology report • Pa
Page 7 and 8: Macroscopic description 4. Ink 12 o
Page 9 and 10: Mark margins The anterior half of t
Page 11 and 12: Sagittal sections for processing. 1
Page 13: Microscopic description 4. Assess b
Page 17 and 18: Microscopic description Transformat
Page 19 and 20: Microscopic description • Squamou
Page 21 and 22: Microscopic description • Must al
Page 23 and 24: P16 immunostain • Nuclear and cyt
Page 25 and 26: Ki67 immunostain • Positive cells
Page 27: References • The Bethesda system

Cone biopsy of cervix - Rcpa.tv

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