Cone biopsy of cervix - Rcpa.tv

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Immunoperoxidase stains • Can be useful in some contexts (eg CIN III Vs immature squamous metaplasia) • P16 positivity indicates integration of high risk HPV virus • Positive defined as cytoplasmic and nuclear staining of full thickness of epithelium. Basal staining may be seen but may not be significant.
P16 immunostain • Nuclear and cytoplasmic staining of full thickness of the squamous epithelium • Endocervical glands are negative • Non-dysplastic epithelium is negative.
Page 1 and 2: Cone biopsy of cervix. An example o
Page 3 and 4: Terminology • Cervical intraepith
Page 5 and 6: Contents of histology report • Pa
Page 7 and 8: Macroscopic description 4. Ink 12 o
Page 9 and 10: Mark margins The anterior half of t
Page 11 and 12: Sagittal sections for processing. 1
Page 13 and 14: Microscopic description 4. Assess b
Page 15 and 16: Cervical squamous dysplasia • CIN
Page 17 and 18: Microscopic description Transformat
Page 19 and 20: Microscopic description • Squamou
Page 21: Microscopic description • Must al
Page 25 and 26: Ki67 immunostain • Positive cells
Page 27: References • The Bethesda system

Cone biopsy of cervix - Rcpa.tv

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