SODIUM - LINEAR CHEMICALS

135-155 mmol/L (mEq/L).
REFERENCE VALUES 3,4
QUALITY CONTROL
To ensure adequate quality control (QC), each run should include a
set of controls (normal and abnormal) with assayed values handled
as unknowns.
- Correlation: This assay (y) was compared with a similar commercial
method (x). The results were:
N = 33 r = 0.998 y = 1.022x – 2.07
X Media = 153.53 mmol/L
Y Media = 136.5 mmol/L
The analytical performances have been generated using on automatic
instrument. Results may vary depending on the instrument.
REF
1980005 HUMAN MULTISERA NORMAL
Borderline level of sodium. Assayed.
REFERENCES
REF
1985005 HUMAN MULTISERA ABNORMAL
Elevated level of sodium. Assayed.
CLINICAL SIGNIFICANCE
Sodium is the major cation of extracellular fluid. It plays a central role
in the maintenance of the normal distribution of water and the osmotic
pressure in the various fluid compartments. The main source of body
sodium is sodium chloride contained in ingested foods. Only about
one-third of the total body’s sodium is contained in the skeleton since
most of it is contained in the extracellular body fluids. 1,2
Hyponatremia (low serum sodium level) is found in a variety
of conditions including the following: severe polyuria,
metabolic acidosis, Addison's disease, diarrhea, and renal tubular
disease. Hypernatremia (increased serum sodium level) is found in
the following conditions: hyperadrenalism, severe dehydration,
diabetic coma after therapy with insulin, excess treatment with
sodium salts. 3,4
1.
2.
3.
4.
5.
6.
Trinder, P. Analyst, 76:596, (1951).
Maruna RFL. Clin. Chem Acta, 2:581, (1958).
Tietz, N.W., Fundamentals of Clinical Chemistry, W.B. Saunder
Co., Phila, PA, p. 874.
Henry R.F., et. al., Clinical Chemistry Principles and Technics,
2nd Ed., Harper and Row, Hagerstein, M.D., (1974).
Young DS. Effects of drugs on clinical laboratory tests, 5th
ed. AACC Press, 2000.
Friedman and Young. Effects of disease on clinical laboratory
tests, 5 th AACC Press 2000.
NOTES
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Do not pipette the solution by mouth. Avoid ingestion/contact.
Specimens should be considered infectious and handled
appropriately.
When preparing filtrates, inadequate shaking or centrifugation
will cause falsely lowered test results.
Blood calcium, chloride, and potassium levels of up to 3 times
the normal reportedly exert no adverse influence on the
procedure; phosphorus levels exceeding 5 times the normal
likewise present no problems.
The Color reagent, becomes discoloured when exposed to the
light. Store protected from light. A slight turbidity does not affect
the determination.
Detergents usually contain high sodium concentrations. The
equipment – test tubes, pipettes, stoppers, cuvettes – must
therefore be rinsed carefully with distilled water.
Disposable plastic tubes are recommended for the determination.
Use Parafilm or plastic stoppers to close the tubes.
ANALYTICAL PERFORMANCE
- Linearity : Up to 300 mmol/L
- Precision:
mmol/L Within-run Between-run
Mean 94.1 155.8 198.9 94.1 155.8 198.9
SD 2.01 1.39 0.80 4.02 5.40 6.69
CV% 2.13 0.89 0.40 4.28 3.47 3.37
N 6 6 6 10 10 10
- Sensitivity : 1.5 mA / mmol/L sodium.
B1151-1/0504
R1.ing
QUALITY SYSTEM CERTIFIED
ISO 9001 ISO 13485
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