The Industry's Preeminent Event on Novel Drug Targets ...

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Inaugural n September 24 - 25, 2013 Antibodies DTB Against Membrane Protein Targets Part One: <strong>The</strong>rapeutic Antibodies for Membrane Targets »» Suggested <strong>Event</strong> Package September 23: FGN Practical Aspects of Structure-Based Drug Discovery with GPCRs Short Course 2 September 23: Production and Presentation of Integral Membrane Proteins for Antibody Discovery Short Course 7 September 24-25: Antibodies Against Membrane Protein Targets Conference Part CVT One September 25-26: Antibodies Against Membrane Protein Targets Conference Part Two Tuesday, September 24 7:00 am Registration and Morning Coffee BIOLOGY OF GPCR ANTIBODY TARGETS 8:10 Chairperson’s Opening Remarks Christopher Koth, Ph.D., Senior Scientist, Structural Biology, Genentech 8:15 FEATURED PRESENTATION: Probing GPCR Dynamics Using Genetically-Encoded Unnatural Amino Acids Thomas P. Sakmar, M.D., Richard M. & Isabel P. Furlaud Professor, Laboratory of Chemical Biology & Signal Transduction, <strong>The</strong> Rockefeller University 8:45 Conformationally Sensitive Camelid Antibodies to Stabilize GPCR-G Protein Complexes Roger Sunahara, Ph.D., Assistant Professor of Pharmacology, University of Michigan 9:15 LY2951742, an Antibody to Calcitonin Gene-Related Peptide (CGRP) for Prevention of Migraine Headaches David S. Grayzel, M.D., CEO, Arteaus <strong>The</strong>rapeutics 9:45 Grand Opening Coffee Break in the Exhibit Hall with Poster Viewing 10:45 Nanobodies for the Structural and Functional Characterization of GPCR Transmembrane Signaling: From Structure to Function to Drugs Jan Steyaert, Ph.D., Head of Department, Structural Biology, Vrije University Brussels, Belgium 11:15 Antibodies Against Difficult Targets: How to Sponsored by Tackle G-Protein Coupled Receptors Stefanie Urlinger, Ph.D., Director, Research & Development, MorphoSys AG 11:45 Monoclonal Antibodies Against Endothelin A and B Human GPCR Subtypes Frederic Ducancel, Ph.D., Head of Laboratory, Institute of Biology and Technology, Saclay, Atomic Energy Commission, France 12:15 A Novel Regulatory Role of a Humanized Anti-CCR4 Antibody in Cancer Immunotherapy DeKuan Chang, Ph.D., Research Fellow, Cancer Immunology & AIDS, Dana- Farber Cancer Institute 12:45 LUNCHEON PRESENTATION: New Era of GPCR Sponsored by Drug Discovery: Multi-Pathway Screening Technologies Elizabeth R. Quinn, Ph.D., Director, LeadHunter Discovery Services, DiscoveRx Corporation TARGETING MEMBRANE PROTEINS WITH ANTIBODY FRAGMENTS AND NOVEL PROTEIN SCAFFOLDS 2:15 Chairperson’s Opening Remarks Kristen M. Picha, Ph.D., Director, Biology, Centyrex, Johnson & Johnson Ventures, Janssen Pharmaceuticals 2:20 Isolation of Antibody Fragments and Alternative Scaffolds from in vivo and in vitro Sources Against Membrane Protein Targets Hilmar Ebersbach, Ph.D., Lab Head, Antibody Generation, NIBR Biologics Center, Novartis Institutes for BioMedical Research, Switzerland 2:50 Rapid Identification and Characterization of Fabs for Structural Analysis of Membrane Proteins Charles S. Craik, Ph.D., Professor of Pharmaceutical Chemistry, Pharmacology, Biochemistry and Biophysics, University of California, San Francisco 3:20 Sponsored Presentation (Opportunity Available) 3:50 Refreshment Break in the Exhibit Hall with Poster Viewing 4:30 A Bi-Specific Centyrin Targeting EGFR and c-Met Inhibits Cellular Signaling through Avidity Kristen M. Picha, Ph.D., Director, Biology, Centyrex, Johnson & Johnson Ventures, Janssen Pharmaceuticals 5:00 Nanobodies as Highly Specific Antagonists and Agonists of the P2X7 Ion Channel Friedrich Koch-Nolte, Ph.D., Professor, Immunology, Molecular Biology, University Medical Center Hamburg, Germany 5:30 Interactive Breakout Discussion Groups 6:30 Welcome Reception in the Exhibit Hall with Poster Viewing 7:30 Close of Day Wednesday, September 25 7:30 am Registration and Morning Coffee ION CHANNELS AND OTHER TARGETS 8:00 Chairperson’s Opening Remarks Matthew Gardener, Ph.D., Senior Scientist, ADPE, MedImmune, United Kingdom 8:05 FEATURED PRESENTATION: Protease-Resistant IgG Platform Targeting Cell Surface Proteins for Anti-Tumor and Anti-Bacterial <strong>The</strong>rapy William R. Strohl, Ph.D., Vice President, Biologics Research, Janssen Research & Development, LLC 8:35 Antibody <strong>The</strong>rapeutics Targeting Ion Channels: Are We <strong>The</strong>re Yet? Han Sun, Researcher, <strong>The</strong> Solomon H. Snyder Department of Neuroscience, Johns Hopkins Ion Channel Center, High Throughput Biology Center, School of Medicine, Johns Hopkins University 9:05 Ion Channels as Targets for Monoclonal Antibodies Matthew Gardener, Ph.D., Senior Scientist, ADPE, MedImmune, United Kingdom 9:35 Novel Strategies for Identification and Sponsored by Characterization of Human Antibodies Against Nav1.7 Ion Channel Target Hans de Haard, Ph.D., Professor, University of Utrecht, CSO, arGEN-X BV 10:05 Coffee Break in the Exhibit Hall with Poster Viewing 10:50 XMetS, an Allosteric Modulator Antibody to the Insulin Receptor (INSR) that Enhances Insulin Binding to INSR and Restores Glycemic Control in Mouse Models of Diabetes Hassan Issafras, Ph.D., Senior Scientist, Molecular Interactions & Biophysics, Preclinical Research, XOMA Corp. 11:20 Engineering Novel <strong>The</strong>rapeutics Targeting the Ion Channel Kv1.3 Ronald V. Swanson, Ph.D., Senior Director, Biologics Research, Janssen Pharmaceuticals 11:50 Lunch on Your Own 1:40 PLENARY KEYNOTE PRESENTATIONS See Page 3 for Details 3:10-3:50 pm Refreshment Break in the Exhibit Hall with Poster Viewing 3:50 Close of Conference 18 DiscoveryOnTarget.com
Inaugural n September 25 - 26, 2013 Antibodies DTB Against Membrane Protein Targets Part Two: Membrane Protein Production, Structural Biology and Characterization »» Suggested <strong>Event</strong> Package September 23: FGN Production and Presentation of Integral Membrane Proteins for Antibody Discovery Short Course 7 September 24-25: Antibodies Against Membrane Protein Targets Conference Part One September 25-26: Antibodies Against Membrane Protein Targets Conference Part Two CVT Wednesday, September 25 11:50 am Registration 1:30 pm Chairperson’s Opening Remarks 1:40 PLENARY KEYNOTE PRESENTATIONS See Page 3 for Details 3:10-3:50 Refreshment Break in the Exhibit Hall with Poster Viewing STRUCTURAL BIOLOGY AND CHARACTERIZATION OF ANTIBODY-MEMBRANE PROTEIN INTERACTIONS 3:50 Chairperson’s Remarks Hassan Issafras, Ph.D., Senior Scientist, Molecular Interactions & Biophysics, Preclinical Research, XOMA Corp. 4:00 Synthetic Antibodies to Probe the Structural and Conformational Diversity of GPCRs and <strong>The</strong>ir Signaling Complexes Arun Shukla, Ph.D., Assistant Professor, Medicine, Duke University Medical Center 4:30 Sponsored Presentations (Opportunities Available) 5:00 Antibody Inhibition of Bacterial Manganese Transport Christopher Koth, Ph.D., Senior Scientist, Structural Biology, Genentech 5:30 On-Cell, Solution Binding Affinity Measurements for Membrane Targets Palaniswami Rathanaswami, Ph.D., Senior Scientist, Amgen, Canada 6:00 <strong>The</strong>rapeutic Targeting of Homeostatic Chemokine Receptors with Antibodies Eldar Kim, Ph.D., Chief Scientific Officer, MSM Protein Technologies, Inc. 6:30 Close of Day Thursday, September 26 7:30 am Registration MEMBRANE PROTEIN EXPRESSION AND IMMUNIZATION TECHNOLOGIES 8:00 Breakfast Interactive Breakout Discussion Groups 9:05 Chairperson’s Opening Remarks Partha Chowdhury, Ph.D., Principal Scientist, MedImmune 9:10 Evolution of Stable and High Expressing GPCRs for Structure Determination and as Screening Targets Pascal Egloff, Ph.D., Scientist, Plückthun Laboratories, Biochemistry Institute, University of Zürich, Switzerland 9:40 Application of Tetrahymena <strong>The</strong>rmophila as an Alternative Platform for Difficult to Express Immunogens Gregory Carven, Ph.D., Associate Research Fellow, Head of Hybridoma Research, Pfizer 10:10 Coffee Break in the Exhibit Hall with Poster Viewing 10:55 Immunization Strategy for Multiplex Target Validation and <strong>The</strong>rapeutic Antibody Generation Partha Chowdhury, Ph.D., Principal Scientist, MedImmune 11:25 Casting a Wide Net: Strategies to Meet the Challenges of Multi-Transmembrane Targets Meredith Hazen, Senior Research Associate, Genentech 11:55 Expression and Purification of Ligand Gated Ion Channels and Applications in Drug Discovery Arjan Snijder, Ph.D., Associate Principal Scientist, Discovery Sciences, AstraZeneca, Sweden 12:25 pm Chicken Monoclonal Antibodies to Native Sponsored by Conformation GPCRs and Ion Channels Crystal B ioscience Bill Harriman, Ph.D., MBA, Chief Science Officer, Crystal Bioscience 12:55 Native & Full Length Membrane Protein Sponsored by Isolation for Antibody Development and Drug Discovery Anass Jawhari, Ph.D., CSO, Membrane Protein Alliance TECHNOLOGIES TO ENABLE ANTIBODY MEMBRANE TARGET DISCOVERY 2:25 Chairperson’s Opening Remarks Susan Lacy, Ph.D., Associate Director, AbbVie Bioresearch Center 2:30 User Perspective on Commercial Technologies for Antibody Generation to Multi-Spanning Membrane Proteins Susan Lacy, Ph.D., Associate Director, AbbVie Bioresearch Center 3:00 Biacore Assay Development for GPCR Antibody Targets Rick Chu, Ph.D., Principal Investigator, Genzyme 3:30 Ice Cream Refreshment Break in the Exhibit Hall with Poster Viewing 4:00 Generating <strong>The</strong>rapeutic Antibodies against Complex Membrane Targets: Case Studies Using the XenoMouse Discovery Platform Chadwick T. King, Ph.D., Principal Scientist, Amgen, Canada 4:30 Using Stabilized Receptors to Generate <strong>The</strong>rapeutic Antibodies to GPCR Targets Cath Hutchings, Ph.D., Antibody Project Manager, Heptares <strong>The</strong>rapeutics Ltd., United Kingdom 5:00 Isolation of High-Content Single-Domain Antibodies from a Synthetic Library Ario de Marco, Ph.D., Director, TAb-IP Platform, Institut Curie, France 5:30 Ligand and Antibody Binding Studies on immobilized Cannabinoid Receptor Type II (CB 2 ) Silvia Locatelli-Hoops, Ph.D., Scientist, National Institute on Alcohol Abuse & Alcoholism, Laboratory of Membrane Biochemistry and Biophysics, National Institutes of Health 6:00 Close of Conference DiscoveryOnTarget.com 19
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