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Aposense Pipeline: From Platform to Products

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Molecular Imaging of Apop<strong>to</strong>sis:<br />

Phase 2: Design and Status<br />

CA004<br />

Brain<br />

metastases<br />

∆<br />

∆<br />

SRS<br />

24h<br />

8 weeks<br />

Diagnosis &<br />

Eligibility<br />

Baseline<br />

Ana<strong>to</strong>mical<br />

Imaging<br />

Baseline<br />

ML-10<br />

Imaging<br />

Treatment<br />

Follow-up<br />

ML-10<br />

Imaging<br />

Follow-up<br />

Ana<strong>to</strong>mical<br />

Imaging<br />

1w<br />

Combined Chemo-Radiation<br />

7 weeks<br />

8 weeks<br />

CA007<br />

H&N and<br />

NSCLC<br />

∆<br />

∆<br />

Timeline<br />

CA004 Brain metastases treated with SRS<br />

Recruitment<br />

Completed<br />

CA007 H&N treated with chemo-radiation Oc<strong>to</strong>ber 2012<br />

CA007 Lung treated with chemo-radiation Postponed, image<br />

analysis<br />

Results<br />

November 2012<br />

February 2013<br />

Safety status:<br />

212 procedures<br />

106 patients<br />

No related<br />

adverse event<br />

Forward-Looking Information Notice: The Company’s assessments and estimates regarding the above timeline depend,<br />

among other fac<strong>to</strong>rs, on continuation of present patient recruitment rate, sufficient clinical data and successful clinical trials<br />

results analysis, and other risk fac<strong>to</strong>rs which apply <strong>to</strong> the Company’s activity, as described on Company’s annual reports

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