Aposense Pipeline: From Platform to Products
Aposense Pipeline: From Platform to Products
Aposense Pipeline: From Platform to Products
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Discovery<br />
In Vivo<br />
In Vitro<br />
• Medicinal chemistry<br />
• Rational drug design<br />
• Molecular modeling<br />
• Synthesis via network of contrac<strong>to</strong>rs<br />
• Fully equipped biochemistry lab<br />
• Licensed radioactive suite for β<br />
emitters<br />
• Cancer cell lines bank<br />
• Established apop<strong>to</strong>sis models<br />
• Cy<strong>to</strong><strong>to</strong>xic drug handling<br />
• Cell culture<br />
unit<br />
• Animal house,<br />
wild type species<br />
and immune<br />
deficient mice<br />
• An array of established<br />
xenograft mice models<br />
• In-house his<strong>to</strong>logy unit for sectioning<br />
and various staining techniques with<br />
<strong>to</strong>p tier his<strong>to</strong>pathologists consultancy<br />
• Expertise in IV and oral formulations,<br />
including poorly soluble drugs<br />
• CRO network for formal pre-clinical<br />
development, PK/PD, oralbioavailability,<br />
ADME and<br />
<strong>to</strong>xicology studies<br />
• In-house management of<br />
CMC via contrac<strong>to</strong>rs<br />
Final<br />
Drug Product
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