Aposense Pipeline: From Platform to Products
Aposense Pipeline: From Platform to Products
Aposense Pipeline: From Platform to Products
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ATT-11T is >13X More Selective <strong>to</strong> Tumor<br />
Bio-distribution studies in A375 bearing mice; concentration of SN38 (active metabolite) in Tumor and Muscle<br />
ng/gr*hr<br />
(AUC)<br />
4000<br />
3000<br />
3855<br />
Tumor<br />
Tumor/Muscle Selectivity Ratio<br />
2000<br />
1000<br />
0<br />
ATT-11T<br />
1153<br />
Irinotecan<br />
200<br />
160<br />
120<br />
200<br />
ng/gr*hr<br />
(AUC)<br />
80<br />
Muscle<br />
80<br />
40<br />
14.8<br />
60<br />
40<br />
78<br />
0<br />
ATT-11T<br />
Irinotecan<br />
20<br />
0<br />
19.2<br />
ATT-11T<br />
Irinotecan
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