Donderdag <strong>22</strong> <strong>maart</strong> <strong>2012</strong> COIN study group and Dutch Initiative on Crohn and Colitis, 1 Dept. of <strong>Gastro</strong>enterology and Hepatology, University Medical Center Utrecht, Utrecht, 2 Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, 3 Dept. of <strong>Gastro</strong>enterology and Hepatology, University Medical Center Groningen, Groningen, 4 Dept. of <strong>Gastro</strong>enterology and Hepatology, VU University Medical Center, Amsterdam, 5 Dept. of <strong>Gastro</strong>enterology and Hepatology, Radboud University Nijmegen Medical Center, Nijmegen, 6Dept. of <strong>Gastro</strong>enterology and Hepatology, Maastricht University Medical Center, Maastricht, The Netherlands, 7 Dept. of <strong>Gastro</strong>enterology and Hepatology, Erasmus University Medical Center, Rotterdam, 8 Dept. of <strong>Gastro</strong>enterology and Hepatology, Orbis Medical Center, Sittard, 9 Dept. of <strong>Gastro</strong>enterology and Hepatology, Diaconessenhuis, Leiden, 10 Dept. of <strong>Gastro</strong>enterology and Hepatology, Onze Lieve Vrouwe Gasthuis, Amsterdam, 11 Dept. of <strong>Gastro</strong>enterology and Hepatology, Slingeland Hospital, Doetinchem, 12Dept. of <strong>Gastro</strong>enterology and Hepatology, Antonius Hospital, Nieuwegein, 13 Dept. of <strong>Gastro</strong>enterology and Hepatology, Academic Medical Center Amsterdam, 14 Dept. of <strong>Gastro</strong>enterology and Hepatology, Reinier de Graaf Groep, Delft, 15 Dept. of <strong>Gastro</strong>enterology and Hepatology, Meander Medical Center, Amersfoort, The Netherlands 11.00 Parent of origin effects for IL12B and NOD2 in Inflammatory Bowel Disease K. Fransen 1,2 , M. Mitrovic 1,3 , C.C. van Diemen 1 , B.K. Thelma 4 , S. Senapati 4 , U. Potocnik 3 , H. W. Verspagert 5 , C.IJ. Ponsioen 6 , D. de Jong 7 , I. Nolte 8 , R. K. Weersma 1 , 1 Dept. of <strong>Gastro</strong>enterology and Hepatology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands, 2 Dept. of Genetics, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands, 3 Center for Human Molecular Genetics and Pharmacogenomics, Medical Faculty, University of Maribor, Maribor, Slovenia, 4Dept. of Genetics, University of Delhi, South Campus, New Delhi, India, 5 Dept. of <strong>Gastro</strong>enterology and Hepatology, University Medical Centre Leiden, University of Leiden, Leiden, The Netherlands, 6 Dept. of <strong>Gastro</strong>enterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands, 7 Dept. of <strong>Gastro</strong>enterology and Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 8 Dept. of epidemiology, University Medical Centre Groningen and University of Groningen, Groningen, The Netherlands 11.10 Screening for opportunistic infections prior to TNF-alpha inhibitor treatment in Crohn’s disease and the risk of severe infections T.D.G. Belderbos 1 , M. van der Have 1 , H.H. Fidder 1 , M. Leenders 1 , G. Dijkstra 2 , C.P. Peters 3 , E.J. Eshuis 3 , C.Y. Ponsioen 3 , P.D. Siersema 1 , M.G.H. van Oijen 1 , B. Oldenburg 1 on behalf of the Dutch Initiative on Crohn’s and Colitis (ICC), 1 Dept. of <strong>Gastro</strong>enterology and Hepatology, University Medical Center Utrecht, Utrecht, 2 Dept. of <strong>Gastro</strong>enterology and Hepatology, University Medical Center Groningen, Groningen, 3 Dept. of <strong>Gastro</strong>enterology and Hepatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands 11.20 Extensive screening for opportunistic infections prior to biological therapy in patients with Crohn’s disease is not cost-effective M. van der Have, B. Oldenburg, H.H. Fidder, T. Belderbos, F. van der Scheer, P.D. Siersema, M.G. van Oijen, Dept. of <strong>Gastro</strong>enterology and Hepatology, University Medical Center Utrecht, The Netherlands 11.30 Ledenvergadering <strong>Nederlandse</strong> <strong>Vereniging</strong> <strong>voor</strong> <strong>Gastro</strong>enterologie Brabantzaal 12.00 Lunchbuffet in de expositiehal 12
Donderdag <strong>22</strong> <strong>maart</strong> <strong>2012</strong> DEGH-Meeting Baroniezaal Voorzitters: G.R. van den Brink en R.K. Weersma Voordrachten in het Engels, spreektijd 8 minuten, discussietijd 4 minuten Theme Colitis 13.30 Cholinergic anti-inflammatory pathway in DSS-induced colitis C. Cailotto 1 , B.J. Olivier 1 , L. Costes 1 , J. van der Vliet 1 , W.J. de Jonge 1 , G.E. Boeckxstaens 2 , 1Tytgat Institute for Liver and Intestinal Research, AMC, Amsterdam, The Netherlands, 2Dept. of <strong>Gastro</strong>enterology, University Hospital Leuven, Belgium 13.42 Ischemia-induced mucus barrier loss and bacterial penetration are rapidly counteracted by increased goblet cell secretory activity in human and rat colon J. Grootjans 1 , I.H. Hundscheid 1 , K. Lenaerts 1 , B. Boonen 1 , I.B. Renes 2 , F.K. Verheyen 3 , C.H. Dejong 1 , M.F. von Meyenfeldt 1 , G.L. Beets 1 , W.A. Buurman 1 , 1 Dept. of Surgery, NUTRIM School for Nutrition, Toxicology & Metabolism, Maastricht University Medical Center, Maastricht, 2 Laboratory of Pediatrics, Division of Neonatology, Erasmus MC-Sophia, Rotterdam, 3 Dept. of Molecular Cell Biology, Electron Microscopy Unit, Maastricht University Medical Center, Maastricht, The Netherlands 13.54 The human colon is more resistant to ischemia-reperfusion induced tissue damage and early inflammation than human small intestine I.H.R. Hundscheid 1 , J. Grootjans 1 , B. Boonen 1 , J.G. Bloemen 1 , K. Lenaerts 1 , C.H.C. Dejong 1 , M.F. Von Meyenfeld 1 , G.L. Beets 1 , W.A. Buurman 1 , 1 Dept. of Surgery, NUTRIM School for Nutrition, Toxicology & Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands 14.06 Pregnane X Receptor stimulation reduces NF-kappaB mediated cytokine expression in intestinal biopsies from inflammatory bowel disease patients J.J. Deuring 1 , T. van den Berg 1 , E.J. Kuipers 1 , M.P. Peppelenbosch 1 , C. de Haar 1* , C.J. van der Woude 1* , * These authors contributed equally to this work, 1 Erasmus Medical Centre, <strong>Gastro</strong>enterology and Hepatology, Rotterdam, The Netherlands 14.18 Invited Speaker Endoplasmatic reticulum stress and inflammation Prof. dr. G.R. van den Brink, Dept of <strong>Gastro</strong>enterology and Hepatology, Academic Medical Center Amsterdam. 15.00 Theepauze en ALV <strong>Nederlandse</strong> <strong>Vereniging</strong> <strong>voor</strong> Hepatologie 13