Poster rounds DEGH meeting Thursday, March <strong>22</strong>nd 8. MicroRNAs as biomarkers for the response on chemoradiotherapy in esophageal cancer. E.L.A. Toxopeus 1 , W.R.R. Farid 1 , K. Biermann 2 , H.W. Tilanus 1 , B.P.L. Wijnhoven 1 , L.J.W. van der Laan 1 , Depts of 1 Surgery and 2 Pathology, Erasmus MC – University Medical Centre, Rotterdam, The Netherlands 9. Tumor-infiltrating regulatory T cells favor tumor development by suppressing local tumor-specific T cell responses in primary and metastatic liver cancer A. Pedroza-Gonzalez 1 , C. Verhoef 2 , J.N.M. IJzermans 2 , M.P. Peppelenbosch 1 , J. Kwekkeboom 1 , H.L.A. Janssen 1 , D. Sprengers 1 , 1 Dept of <strong>Gastro</strong>enterology and Hepatology, 2 Dept of Surgery, The Netherlands 10. Retinoic acid metabolism in Barrett’s esophagus, duodenum and normal esophagus A. Lind 1,2 , L. Koenderman 2 , J.G. Kusters 3 , T. Konijn 4 , R. Mebius 4 , Peter D. Siersema 1 , 1 <strong>Gastro</strong>entertology and Hepatology, UMC Utrecht, 2 Respiratory medicine, UCM Utrecht, 3 Microbiology, UMC Utrecht, 4 Immunology, VU medical Center, The Netherlands Theme Immunology 1 – Chair: J.P.H. Drenth and R.K. Weersma 11. Immunological changes in IBD patients clinically responding to low-dose naltrexone treatment C. de Haar 1 , C. van der Ent 1 , M.P. Peppelenbosch 1 , C. Janneke van der Woude 1 , 1 Dept of <strong>Gastro</strong>enterology & Hepatology, Erasmus MC, Rotterdam, The Netherlands 12. Serum IP-10 levels correlate with virus load in hepatitis C infected chimpanzees and evidence for novel IL-28B polymorphism B.E. Verstrepen @# , N.G. de Groot @$ , Z.M.A. Groothuismink * , E.J. Verschoor # , R.A. de Groen * , W.M. Bogers # , H.L.A. Janssen * , P. Mooij # , R.E. Bontrop $ , G. Koopman # , A. Boonstra * , # Dept of Virology, Biomedical Primate Research Centre, Rijswijk, $ Dept of Comparative Genetics and Refinement, Biomedical Primate Research Centre, Rijswijk, * Dept. of <strong>Gastro</strong>enterology and Hepatology, Erasmus MC University Hospital, Rotterdam, The Netherlands @ both authors contributed equally to this work 13. Cytokine induced colonic epithelial barrier dysfunction is mediated by cholinergic receptors by an nf-kb independent mechanism S. Dhawan 1 , F.W. Hilbers 1 , L.E.M. Willemsen 3 , I.H. Hiemstra 2 , J.M.M. den Haan 2 , W.J. de Jonge 1 , 1 Tytgat Institute for Liver and Intestinal Diseases, Academisch Medisch Centrum, Amsterdam, 2 Dept. of Molecular Cell Biology and Immunology, VU University Medical Centre, Amsterdam, 3 Utrecht Institute of Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, The Netherlands 14. Functional and genetic alterations of the intestinal barrier in compensated cirrhotic patients K.E. Pijls 1 , D.M.A.E. Jonkers 1 , H. de Vries 1 , E. Schaepkens 1 , A.A.M. Masclee 1 , G.H. Koek 1 , 1 Dept of Internal Medicine, Division of <strong>Gastro</strong>enterology and Hepatology, Maastricht University Medical Center, The Netherlands 42
Poster rounds DEGH meeting Thursday, March <strong>22</strong>nd Theme Immunology 2 – Chair: K.N. Faber and A.A. te Velde 15. Histone deacetylase dependent regulation of cytokine secretion in murine and human macrophages R. Schilderink 1 , F. W. Hilbers 1 , J. Duarte 1 , W. de Jonge 1 , 1 Tytgat institute for liver and intestinal research, Academic medical Center (AMC), Amsterdam, The Netherlands 16. Optimizing induction of CD8+ regulatory T cells by allogeneic human plasmacytoid dendritic cells P.P.C. Boor 1 , S. Mancham 1 , L.W.J. van der Laan 2 , H.J. Metselaar 1 , J. Kwekkeboom 1 , Departments of 1 <strong>Gastro</strong>enterology and Hepatology, 2 Surgery, Erasmus MC-University Medical Centre, Rotterdam, The Netherlands 17. Suppressive macrophage phenotype is regulated via retinoic acid in the intestines G. Goverse, T. Konijn, R. Molenaar, R. Mebius ,VU University Medical Center, Amsterdam, The Netherlands 18 Hepatitis B virus infection activates Kupffer cells A. Boltjes § , H.L.A. Janssen § , A.M. Woltman § , A. Boonstra § , § Dept. of <strong>Gastro</strong>enterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands 43