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Poster rounds DEGH meeting<br />

Thursday, March <strong>22</strong>nd<br />

Theme<br />

Cell Biology and Metabolism – Chair: D. Jonkers and S.W.C. van Mil<br />

1. ER stress in Paneth cells of inactive Crohn’s disease patients with ATG16L1 mutations<br />

J. J. Deuring 1 , M. P. Peppelenbosch 1 , E. J. Kuipers 1 , C. de Haar 1* , C. J. van der Woude 1* ,<br />

*These authors contributed equally to this work , 1 Erasmus Medical Centre, <strong>Gastro</strong>enterology<br />

and Hepatology, Rotterdam, The Netherlands<br />

2. The role of cell division orientation in liver development<br />

C.L. Slim 1 , F. Lazaro-Dieguez 2 , D. Cohen 2 , L. Penning 3 , H. Toussaint 3 , A. de Bruin 3 , D.<br />

Hoekstra 1 , A. Muesch 2 , S.C.D. van IJzendoorn 1 , 1 Dept of Cell Biology, Section of Membrane Cell<br />

Biology, University Medical Center Groningen, University of Groningen, Groningen, The<br />

Netherlands, 2 Dept of Developmental & Molecular Biology, Albert Einstein College of Medicine,<br />

New York, USA 3 Faculty of Veterinary Medicine, Dept of Pathobiology, Utrecht University,<br />

Utrecht, The Netherlands<br />

3. Targeting specific FXR isoforms in the bile acid biosynthetic pathway<br />

M. Boesjes 1 , J. Hageman 1 , V.W. Bloks 1 , H. Havinga 1 , F. Kuipers 1,2 , A.K. Groen 1,2 , Laboratory of<br />

1Pediatrics and 2 Laboratory Medicine, Center for Liver, Digestive and Metabolic Diseases,<br />

University Medical Center Groningen, Groningen, The Netherlands<br />

4. Renal NKCC2 transporter triggers enhanced urinary ammonia excretion during induced<br />

hyperammonemia: a novel target of therapy for hepatic encephalopathy?<br />

L. Mpabanzi 1,2,3 , D. Dhar 2 , C.H.C. Dejong 1 , R. Jalan 3 , S.W.M. Olde Damink 1,2 , 1 Dept of Surgery,<br />

Maastricht University Medical Centre, and NUTRIM School of Nutrition, Toxicology and<br />

Metabolism, Maastricht University, Maastricht, The Netherlands, 2 Hepato-Pancreato-Biliary and<br />

Liver Transplant Surgery, Royal Free Hospital, University College London, London, UK, 3 Liver<br />

Failure Group, UCL Hepatology, Royal Free Hospital, University College London, United Kingdom<br />

5. Somatic inactivation in polycystic liver SEC63 germline carriers occurs through loss of<br />

heterozygosity<br />

M.J. Janssen 1 , J. Salomon 1 , R.H.M. te Morsche 1 , J.P.H. Drenth 1 , 1 Dept of <strong>Gastro</strong>enterology &<br />

Hepatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands<br />

Theme<br />

Metaplasia and Cancer – Chair: G. Bouma and C.C. Paulusma<br />

6. Toll-Like Receptor 4 activation may promote development of esophageal adenocarcinoma<br />

in Barrett’s esophagus through induction of COX2<br />

R.E. Verbeek 1 , P.D. Siersema 1 , P. Bus 1 , F.J. ten Kate 2 , K. Fluiter 3 , R.F. Souza 4 , F.P. Vleggaar 1 ,<br />

J.W.P.M. van Baal 1 , 1 Dept. of <strong>Gastro</strong>enterology and Hepatology, 2 Dept. of Pathology, University<br />

Medical Center Utrecht, 3 Dept. of Neurogenetics, Academic Medical Center, University of<br />

Amsterdam, The Netherlands, 4 University of Texas Southwestern Medical Center, Dallas, Texas<br />

7. Stool proteomics reveals new candidate biomarkers for colorectal cancer screening<br />

L.J.W. Bosch 1 , M. de Wit 2 , G. Oudgenoeg 2 , A.C. Hiemstra 1 , S. Mongera 1 , S.R. Piersma 2 , T.V.<br />

Pham 2 , N.C.T. van Grieken 2 , J.S. Terhaar sive Droste 2 , F.A. Oort 3 , S.T. van Turenhout 3 , I. Ben<br />

Larbi 3 , C.J.J. Mulder 3 , B. Carvalho 1 , C.R. Jimenez 2 , R.J.A. Fijneman 1 , G.A. Meijer 1 , 1 Dept of<br />

Pathology, VU University Medical Center, Amsterdam, 2 Dept of Medical Oncology, VU University<br />

Medical Center, Amsterdam, 3 Dept of <strong>Gastro</strong>enterology and Hepatology, VU University Medical<br />

Center, Amsterdam, The Netherlands<br />

41

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