Progressive Supranuclear Palsy

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Supportive Criteria for Dx PSP

Symmetric akinesia or rigidity

Abnormal neck posture, especially

retrocollis

Poor or absent response of parkinsonism

to levodopa therapy

Early dysphagia and dysarthria

Early onset of cognitive impairment,

including at least 2 of these: apathy,

decreased verbal fluency, impaired

abstract reasoning, and utilization

behavior

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Criteria for Dx PSP Gradually progressive disorder Onset at age 40 years old or later Vertical supranuclear palsy Slowing of vertical saccades Postural instability with falls in the first year of disease onset

Supportive Criteria for Dx PSP Symmetric akinesia or rigidity Abnormal neck posture, especially retrocollis Poor or absent response of parkinsonism to levodopa therapy Early dysphagia and dysarthria Early onset of cognitive impairment, including at least 2 of these: apathy, decreased verbal fluency, impaired abstract reasoning, and utilization behavior

Page 1: HARVARD MEDICAL SCHOOL DEPARTMENT O
Page 5 and 6: Clinical Features of PSP Smooth eye
Page 7 and 8: Neuroimaging Figure 1: Sagittal T2-
Page 9: Figure 3. PET in a patient with PSP
Page 12 and 13: Pathology Figure 6: PSP-the-globose
Page 17 and 18: Tauopathies: Clinical Diseases Alzh
Page 19 and 20: Richardson JC, Steele J, Oszewski J

Progressive Supranuclear Palsy

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