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Deborah U. Frank, M.D., Ph.D. - Pediatrics - University of Utah

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Curriculum Vitae Last Updated: 08/08/2013<br />

PERSONAL DATA<br />

Name: <strong>Deborah</strong> U. <strong>Frank</strong><br />

Birth Place: Red Bank, New Jersey<br />

Citizenship: United States<br />

Added to the file by faculty request 8/20/13.<br />

EDUCATION<br />

Years Degree Institution (Area <strong>of</strong> Study)<br />

1987 - 1991 B.S. Northwestern <strong>University</strong> (Biomedical Engineering)<br />

Evanston, IL<br />

1991 - 1998 M.D. <strong>University</strong> <strong>of</strong> Virginia, School <strong>of</strong> Medicine (Medicine)<br />

Charlottesville, VA<br />

1993 - 1997 <strong>Ph</strong>.D. <strong>University</strong> <strong>of</strong> Virginia, School <strong>of</strong> Engineering and Applied<br />

Science (Biomedical Engineering)<br />

Charlottesville, VA<br />

1998 - 2001 Resident <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, School <strong>of</strong> Medicine (<strong>Pediatrics</strong>)<br />

Salt Lake City, UT<br />

2001 - 2006 Postdoctoral Fellow <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, Human Molecular Biology and Genetics<br />

(Cardiac Development)<br />

Salt Lake City, UT<br />

2001 - 2004 Fellow <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, School <strong>of</strong> Medicine (Pediatric Cardiology)<br />

Salt Lake City, UT<br />

2004 - 2006 Fellow <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, School <strong>of</strong> Medicine (Pediatric Critical Care)<br />

Salt Lake City, UT<br />

2004 - 2006 Visiting Fellow The Children's Hospital <strong>of</strong> <strong>Ph</strong>iladelphia (Pediatric Cardiac<br />

Intensive Care)<br />

<strong>Ph</strong>iladelphia, PA<br />

BOARD CERTIFICATIONS<br />

05/01/1999 National Board <strong>of</strong> Medical Examiners, Certified<br />

10/16/2001 American Board <strong>of</strong> <strong>Pediatrics</strong> (<strong>Pediatrics</strong>), Has subspecialty board<br />

08/16/2004 American Board <strong>of</strong> <strong>Pediatrics</strong> (Sub: Ped Cardiology), Certified<br />

08/18/2006 American Board <strong>of</strong> <strong>Pediatrics</strong> (Sub: Crit Care Med), Certified<br />

CURRENT LICENSES/CERTIFICATIONS<br />

1998 - 2014 American Heart Association: Pediatric Advanced Life Support (UT) - <strong>Ph</strong>ysician (MD)<br />

2011 - 2013 American Heart Association: Advanced Cardiac Life Support<br />

<strong>Frank</strong>, Page 1


ACADEMIC HISTORY<br />

<strong>Pediatrics</strong> (Pediatric Critical Care)<br />

07/01/2006 Hire, Tenure Track, Instructor<br />

07/01/2009 PromotionAssistant Pr<strong>of</strong>essor<br />

PROFESSIONAL EXPERIENCE<br />

Full Time Positions<br />

2006 - Present Attending <strong>Ph</strong>ysician, Cardiac Intensive Care Unit, Primary Children's Medical<br />

Center, Salt Lake City, <strong>Utah</strong><br />

2006 - 2009 Instructor <strong>of</strong> <strong>Pediatrics</strong>, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, Salt Lake City, <strong>Utah</strong><br />

2009 - Present Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, Salt Lake City, <strong>Utah</strong><br />

Part Time Positions<br />

2001 - 2004 Affiliate <strong>Ph</strong>ysician, Intermountain Healthcare, Kidscare, Salt Lake City, UT<br />

SCHOLASTIC HONORS<br />

1989 Tau Beta Pi Engineering Honor Society, Northwestern <strong>University</strong><br />

1991 Northwestern <strong>University</strong>, Dean’s List for all 12 quarters<br />

1991 Northwestern <strong>University</strong>, Graduated with Distinction<br />

1991 - 1998 <strong>University</strong> <strong>of</strong> Virginia, Medical Scientist Training (MD/<strong>Ph</strong>D) Program<br />

1992 <strong>University</strong> <strong>of</strong> Virginia, Merck Manual Award<br />

1993 American Society <strong>of</strong> Clinical Pathologists’ Award for Academic Excellence and<br />

Achievement, <strong>University</strong> <strong>of</strong> Virginia<br />

1993 - 1997 Virginia Engineering Foundation Fellowships, <strong>University</strong> <strong>of</strong> Virginia<br />

1993 Alpha Omega Alpha Medical Honor Society, <strong>University</strong> <strong>of</strong> Virginia<br />

1998 Robert M. Blizzard Pediatric Scholar Award, <strong>University</strong> <strong>of</strong> Virginia<br />

2001 - 2010 Primary Children’s Medical Foundation Scholar, <strong>University</strong> <strong>of</strong> <strong>Utah</strong><br />

2006 - 2008 Cardiovascular Training Grant T-32, Postdoctoral fellow, <strong>University</strong> <strong>of</strong> <strong>Utah</strong><br />

2008 - 2010 Pediatric Critical Care Scientist Development Program Scholar, K12, <strong>University</strong> <strong>of</strong><br />

<strong>Utah</strong><br />

ADMINISTRATIVE EXPERIENCE<br />

Administrative Duties<br />

2011 - Present CICU Faculty Coordinator, Cardioaccess Database, Cardiac Center, Primary<br />

Children's Medical Center<br />

2012 - Present Research Advocacy Group, Cardiac Center, Primary Children's Medical Center<br />

2012 - Present Member, High Risk Program Steering Committee, Cardiac Center, Primary<br />

Children's Medical Center<br />

2012 - Present Member, Infant Feeding Guidlines Committee for the Cardiac Center, Primary<br />

Children's Medical Center<br />

2012 - Present Chair, Technology Committee for the Pediatric and Cardiac Intensive Care Units at<br />

Primary Children's Medical Center<br />

2013 - Present Culture Champion, Cardiac Center, Primary Children's Medical Center<br />

<strong>Frank</strong>, Page 2


PROFESSIONAL COMMUNITY ACTIVITIES<br />

2012 Medical Team Volunteer, Medical Mission, Pediatric Cardiac Intensive Care<br />

<strong>Ph</strong>ysician on mission to hospital Nacional Dos de Mayo, Lima, Peru with the Hearts<br />

with Hope Foundation, Los Angelos, CA<br />

SERVICE AT PREVIOUS INSTITUTIONS<br />

1994 - 1996 Medical Student Member, <strong>University</strong> <strong>of</strong> Virginia, Human Investigation Committee<br />

(IRB)<br />

CURRENT MEMBERSHIPS IN PROFESSIONAL SOCIETIES<br />

American College <strong>of</strong> Cardiology<br />

American College <strong>of</strong> Cardiology - Congenital Heart Disease and Pediatric Cardiology Section<br />

Pediatirc Cardiac Intensive Care Society<br />

Society <strong>of</strong> Critical Care Medicine<br />

Society <strong>of</strong> Critical Care Medicine - <strong>Pediatrics</strong> Section<br />

FUNDING<br />

Active Grants<br />

03/01/13 -<br />

03/01/14<br />

Past Grants<br />

07/01/02 -<br />

07/01/03<br />

11/01/02 -<br />

11/01/04<br />

01/01/08 -<br />

12/31/09<br />

01/01/08 -<br />

12/31/10<br />

Development <strong>of</strong> Translational Techniques to Evaluate Myocardial Enegertics in<br />

Infants with Single Ventricle <strong>Ph</strong>ysiology on Oxandrolone<br />

Principal Investigator: <strong>Deborah</strong> U. <strong>Frank</strong><br />

Direct Costs: $40,000 Total Costs: $40,000<br />

Primary Children's Medical Center Foundation<br />

Role: Principal Investigator<br />

The role <strong>of</strong> FGF8 in mouse cardiovascular development - Innovative Research Grant,<br />

Mentor: Anne M. Moon, M.D., <strong>Ph</strong>.D.<br />

Principal Investigator: <strong>Deborah</strong> U. <strong>Frank</strong><br />

Direct Costs: $25,000 Total Costs: $25,000<br />

Primary Children's Medical Center Foundation<br />

Role: Principal Investigator<br />

Trial <strong>of</strong> Pulse Steroid Therapy in Kawasaki Disease - Grant # 59001261, Pediatric<br />

Heart Research Network, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, Salt Lake City, UT<br />

Principal Investigator: L. LuAnn Minich<br />

National Heart, Lung, and Blood Institute<br />

Role: Co-Investigator<br />

The role <strong>of</strong> Tbx3 in mouse cardiac development<br />

Principal Investigator: <strong>Deborah</strong> U. <strong>Frank</strong><br />

Direct Costs: $37,500 Total Costs: $37,500<br />

Primary Children's Medical Center Foundation<br />

Role: Principal Investigator<br />

Role <strong>of</strong> Tbx3 in Mouse Cardiac Development<br />

Pediatric Critical Care Scientist Development Program K12<br />

Principal Investigator: <strong>Deborah</strong> U. <strong>Frank</strong><br />

National Institutes <strong>of</strong> Health<br />

Role: Principal Investigator<br />

02/01/09 - Role Of Tbx3 In Mouse Cardiac Development<br />

<strong>Frank</strong>, Page 3


01/31/11 Principal Investigator: <strong>Deborah</strong> U. <strong>Frank</strong><br />

Direct Costs: $136,364 Total Costs: $150,000<br />

March <strong>of</strong> Dimes Foundation<br />

Role: Principal Investigator<br />

TEACHING RESPONSIBILITIES/ASSIGNMENTS<br />

Clinical Teaching<br />

2004 Pediatric Cardiology Fellowship Lecture Series, Myocarditis and Pericarditis<br />

2005 - Present Pediatric Critical Care Fellowship Lecture Series, Echocardiography for ICU<br />

physicians, presented every 2 - 3 years<br />

2005 - 2011 Pediatric Critical Care Fellowship Lecture Series, Staged Palliation <strong>of</strong> Single<br />

Ventricle Lesions, annually<br />

2005 Pediatric Critical Care Fellowship Lecture Series, Clinical Practice Review, CPR<br />

2006 Pediatric Critical Care Fellowship Lecture Series, Clinical Practice Review, ECMO<br />

during and after CPR<br />

2006 Pediatric Cardiology Fellowship Lecture Series, Cardiac Anatomy<br />

2007 Pediatic Resident Noon Lecture, Cardiac Emergencies<br />

2007 Pediatric Cardiology Fellowship Lecture Series, Post-operative Care: Monitoring<br />

Hemodynamics<br />

2009 Pediatric Cardiology Fellowship Lecture Series, Update in Cardiac Intensive Care<br />

2009 Pediatric Resident Noon Lecture, Myocarditis<br />

2011 Pediatric Cardiology Fellowship Lecture Series, Basics <strong>of</strong> Cardiac Intensive Care<br />

2011 - 2012 Pediatric Critical Care Fellowship Lecture Series, Cardiac <strong>Ph</strong>ysiology<br />

Small Group Teaching<br />

2011 - Present Pediatric Cardiology Fellows Board Preparation Sessions - Topic: Cardiac Intensive<br />

Care. Taught during every 3 year cycle. 10/2011, 2/2013.<br />

Trainee Supervision<br />

Fellow<br />

2009 - 2012 Advisor/Mentor, Titus Chan, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>. Scholarship Oversight Committee<br />

2011 - 2013 Advisor/Mentor, Brook Lang, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>. Scholarship Oversight Committee<br />

2013 - 2015 Advisor/Mentor, Hillary Crandal, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>. Scholarship Oversight<br />

Committee<br />

Medical Student<br />

2011 - Present Advisor/Mentor, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>. 2nd year Medical Student Clinical Shadowing<br />

Undergraduate<br />

2005 - 2006 Supervisor, Sarah Elliott, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>. Laboratory Research<br />

Trainee's Current Career Activities: Graduate Student, <strong>University</strong> <strong>of</strong> <strong>Utah</strong><br />

2008 - 2009 Supervisor, Michael Burr, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>. Laboratory Research<br />

Trainee's Current Career Activities: Researcher at Moran Eye Institute<br />

Educational Lectures<br />

Didactic Lectures<br />

2004 Echocardiography for ICU nurses, Pediatric ICU Cardiac Nursing Lecture,<br />

Primary Children's Medical Center, Salt lake City, UT<br />

2007 Stage I Palliation <strong>of</strong> HLHS: BT vs. Sano Shunt. Pediatric ICU Cardiac Nurses<br />

Symposium, Primary Children’s Medical Center, Salt Lake City, UT<br />

2007 Cardiac Assessment. Cardiovascular Nurses Training, Primary Children’s<br />

Medical Center, Salt Lake City, UT<br />

<strong>Frank</strong>, Page 4


Continuing Education<br />

CE Courses Taught<br />

2012 - Present Congenital Core Curriculum Review, Cardiovascular & Thoracic Surgery,<br />

Intermountain Healthcare Continuing Medical Education, Lecutre on Cardiac<br />

Intensive Care and Monitoring for Surgeons preparing for Board Exams. 2012<br />

was inital course year, with 6 attendees.<br />

PEER-REVIEWED JOURNAL ARTICLES<br />

1. Rich, GF, CM Roos, SM Anderson, Urich DC, MO Daugherty, RA Johns. (1993). Inhaled nitric<br />

oxide: dose response and the effects <strong>of</strong> blood in the isolated rat lung. J Appl <strong>Ph</strong>ysiol, 75, 1278-1284.<br />

2. Roos CM, Rich GF, Uncles DR, Daugherty MO, <strong>Frank</strong> DU. (1994). Sites <strong>of</strong> vasodilation by inhaled<br />

nitric oxide vs. sodium nitroprusside in endothelin-constricted isolated rat lungs. J Appl<br />

<strong>Ph</strong>ysiol, 77(1), 51-7.<br />

3. Roos CM, <strong>Frank</strong> DU, Xue C, Johns RA, Rich GF. (1996). Chronic inhaled nitric oxide: effects on<br />

pulmonary vascular endothelial function and pathology in rats. J Appl <strong>Ph</strong>ysiol, 80(1), 252-60.<br />

4. <strong>Frank</strong> DU, Lowson SM, Roos CM, Rich GF. (1996). Endotoxin alters hypoxic pulmonary<br />

vasoconstriction in isolated rat lungs. J Appl <strong>Ph</strong>ysiol, 81(3), 1316-22.<br />

5. Uncles DR, Daugherty MO, <strong>Frank</strong> DU, Roos CM, Rich GF. (1996). Nitric oxide modulation <strong>of</strong><br />

pulmonary vascular resistance is red blood cell dependent in isolated rat lungs. Anesth<br />

Analg, 83(6), 1212-7.<br />

6. Horstman DJ, <strong>Frank</strong> DU, Rich GF. (1998). Prolonged inhaled NO attenuates hypoxic, but not<br />

monocrotaline-induced, pulmonary vascular remodeling in rats. Anesth Analg, 86(1), 74-81.<br />

7. <strong>Frank</strong> DU, Horstman DJ, Morris GN, Johns RA, Rich GF. (1998). Regulation <strong>of</strong> the endogenous<br />

NO pathway by prolonged inhaled NO in rats. J Appl <strong>Ph</strong>ysiol, 85(3), 1070-8.<br />

8. <strong>Frank</strong> DU, Horstman DJ, Rich GF. (1998). The effect <strong>of</strong> prolonged inhaled nitric oxide on<br />

pulmonary vasoconstriction in rats. Anesth Analg, 87(6), 1285-90.<br />

9. Horstman DJ, McCall DA, <strong>Frank</strong> DU, Rich GF. (1999). Inhaled nitric oxide and nifedipine have<br />

similar effects on lung cGMP levels in rats. Anesth Analg, 89(4), 932-7.<br />

10. <strong>Frank</strong> DU, Fotheringham LK, Brewer JA, Muglia LJ, Tristani-Firouzi M, Capecchi MR, Moon AM.<br />

(2002). An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome.<br />

Development, 129(19), 4591-603.<br />

11. <strong>Frank</strong> DU, Minich LL, Shaddy RE, Tani LY. (2002). Is Doppler an accurate predictor <strong>of</strong><br />

catheterization gradients for postoperative branch pulmonary stenosis? J Am Soc<br />

Echocardiogr, 15(10 Pt 2), 1140-4.<br />

12. Macatee TL, Hammond BP, Arenkiel BR, Francis L, <strong>Frank</strong> DU, Moon AM. (2003). Ablation <strong>of</strong><br />

specific expression domains reveals discrete functions <strong>of</strong> ectoderm- and endoderm-derived FGF8<br />

during cardiovascular and pharyngeal development. Development, 130(25), 6361-74.<br />

13. Park EJ, Ogden LA, Talbot A, Evans S, Cai CL, Black BL, <strong>Frank</strong> DU, Moon AM. (2006).<br />

Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling.<br />

Development, 133(12), 2419-33.<br />

14. <strong>Frank</strong> DU, Elliott SA, Park EJ, Hammond J, Saijoh Y, Moon AM. (2007). System for inducible<br />

expression <strong>of</strong> cre-recombinase from the Foxa2 locus in endoderm, notochord, and floor plate. Dev<br />

Dyn, 236(4), 1085-92.<br />

15. Chan T, Thiagarajan RR, <strong>Frank</strong> D, Bratton SL. (2008). Survival after extracorporeal<br />

cardiopulmonary resuscitation in infants and children with heart disease. J Thorac Cardiovasc<br />

Surg, 136(4), 984-92.<br />

16. Printz BF, Sleeper LA, Newburger JW, Minich LL, Bradley T, Cohen MS, <strong>Frank</strong> D, Li JS,<br />

Margossian R, Shirali G, Takahashi M, Colan SD. (2011). Noncoronary cardiac abnormalities are<br />

associated with coronary artery dilation and with laboratory inflammatory markers in acute<br />

<strong>Frank</strong>, Page 5


Kawasaki disease. J Am Coll Cardiol, 57(1), 86-92.<br />

17. <strong>Frank</strong> DU, Carter KL, Thomas KR, Burr RM, Bakker ML, Coetzee WA, Tristani-Firouzi M,<br />

Bamshad MJ, Christ<strong>of</strong>fels VM, Moon AM. (2012). Lethal arrhythmias in Tbx3-deficient mice reveal<br />

extreme dosage sensitivity <strong>of</strong> cardiac conduction system function and homeostasis. Proc Natl Acad<br />

Sci U S A, 109(3), E154-63.<br />

18. Ohye RG, Shonbeck JV, Eghtesady P, Laussen PC, Pizarro C, Shrader P, <strong>Frank</strong> DU, Graham EM,<br />

Hill KD, Jacobs JP, Kanter KR, Kirsch JA, Lambert LM, Lewis AB, Ravishankar C, Tweddell JS,<br />

Williams IA, Pearson GD, for the Pediatric Heart Network Investigators. (2012). Cause, Timing and<br />

Location <strong>of</strong> Death in the Single Ventricle Reconstruction Trial. J Thorac Cardiovasc<br />

Surg, 144(4), 907-14.<br />

19. Tabbutt S, Ghanayem N, Ravishankar C, Sleeper LA, Cooper DS, <strong>Frank</strong> DU, Lu M, Pizarro C,<br />

Frommelt P, Goldberg CS, Graham EM, Krawczeski CD, Lai WW, Lewis A, Kirsh JA, Mahony L,<br />

Ohye RG, Simsic J, Lodge AJ, Spurrier E, Stylianou M, Laussen P, Pediatric Heart Network<br />

Investigators. (2012). Risk factors for hospital morbidity and mortality after the Norwood procedure:<br />

A report from the Pediatric Heart Network Single Ventricle Reconstruction trial. J Thorac<br />

Cardiovasc Surg, 144(4), 882-95.<br />

20. <strong>Frank</strong> DU, Emechebe U, Thomas KR, Moon AM. (2013). Mouse tbx3 mutants suggest novel<br />

molecular mechanisms for ulnar-mammary syndrome. PLoS ONE, 8(7), e67841.<br />

OTHER (Commentary/Letters/Editorials/Case Reports/Video/Film)<br />

Commentary<br />

1. <strong>Frank</strong> D. (2010). Shunt Type in the Norwood Procedure. AAP Grand Rounds, 24(3), 34.<br />

Editorials<br />

1. <strong>Frank</strong> DU, Bratton SL. (2010). What's new in extracorporeal cardiopulmonary resuscitation? Pediatr<br />

Crit Care Med, 11(3), 429-31.<br />

PENDING PUBLICATIONS<br />

Journal Articles<br />

1. Goldberg CS, Lu M, Sleeper LA, Mahle WT, Gaynor JW, Williams IA, Mussatto KA, Ohye RG,<br />

Graham EM, <strong>Frank</strong> DU, Jacobs JP, Krawczeski C, Lambert L, Lewis A, Pemberton VL, Sananes R,<br />

Sood E, Wechsler SB, Newburger JW. (In Revision). Factors Associated with Neurodevelopment for<br />

Children with Single Ventricle Lesions. J Pediatr.<br />

2. Riehle C, Wende AR, Sena S, Pires KM, Pereira-Alambert R, Zhu Y, Bugger H, <strong>Frank</strong> D, Bevins J,<br />

Chen D, Perry-Garza CN, Dong X, Valdez S, Sheng X, Weimer BC, Gottlieb RA, White MF, Abel<br />

ED. (Under Review). Insulin Receptor Substrates are Required for Supressing Neonatal Autophagy in<br />

the Heart. J Clin Invest.<br />

Abstracts<br />

1. Delgado-Corcoran C, Bodily S, <strong>Frank</strong> D, Bratton S. (In Press). Reducing Blood Testing in Pediatric<br />

Patients after Heart Surgery [Abstract]. Pediatric Cardiac Intensive Care Society, 9th International<br />

Conference, December 2012, Miami Beach, FL.<br />

<strong>Frank</strong>, Page 6


Case Reports<br />

1. Bogarapu S, Bleyl SB, Calhoun A, Viskochil DH, Saarel EV, Everitt MD, <strong>Frank</strong> DU. (Submitted).<br />

<strong>Ph</strong>enotype <strong>of</strong> a Patient with Contiguous Deletion <strong>of</strong> TBX5 and TBX3: Expanding the Disease<br />

Spectrum. Am J Hum Genet.<br />

RECENTLY PUBLISHED ABSTRACTS (Last 3 Years)<br />

1. Null D, Bierer R, Dahl M, Jones C, Block C, Jensen S, Wimmer J, Leavitt T, McCoy N, Von Der Ahe<br />

N, Alvord J, Houston D, Dong L, <strong>Frank</strong> D, DiGeronimo R, Yoder B, Albertine K. (2011). IGF-1 and<br />

Caspase 3 Expression Modifications in the Lung and Brain in a ECMO Model Using Term Lambs<br />

[Abstract]. E-PAS2011592.<br />

2. Bierer R, Null D, Dahl M, Jones C, Block C, Jensen S, Wimmer J, Leavitt T, McCoy M, Von Der Ahe<br />

N, Alvord J, Houston B, Dong L, <strong>Frank</strong> D, Digeronimo R, Yoder B, Albertine K. (2011). Stretch,<br />

Rather than Oxygen Exposure, Change Molecular Expression in the Lung in an ECMO Model Using<br />

Term Lambs [Abstract]. E-PAS2011591.<br />

3. Kosaka Y, Lezin G, Gittenberger-de Groot AC, Saijoh Y, <strong>Frank</strong> D, Wisse LJ, Toyo-oka K,<br />

Wynshaw-Boris A, Yost HJ, Brunelli L. (2011). Deletion <strong>of</strong> 14-3-3ε in Mice Leads to Tricuspid<br />

Abnormalities and Gerbode Defect [Abstract]. E-PAS2011:2830.1.<br />

4. Ohye RG, Schonbeck JV, Eghtesady P, Laussen PC, Pizarro C, Shrader P, <strong>Frank</strong> DU, Graham EM,<br />

Hill KD, Jacobs JP, Kanter KR, Kirsh JA, Lambert LM, Lewis AB, Ravishankar C, Tweddell JS,<br />

Williams IA, Pearson GD, for the Pediatric Heart Network Investigators. (2011). Cause, Timing and<br />

Location <strong>of</strong> Death in the Single Ventricle Reconstruction Trial [Abstract]. Circulation, 124, A10098.<br />

5. Ravishankar C, Tabbutt S, Allen K, Cooper DS, <strong>Frank</strong> DU, Frommelt P, Ghanayem N, Goldberg K,<br />

Graham EM, Kirsh JA, Krawczeski C, Lai WW, Lewis AB, Lodge AJ, Mahony L, Simsic J, Sleeper<br />

LA, Stylianou M, Wang Y, Laussen P for the Pediatric Heart Network Investigators. (2011). Impact <strong>of</strong><br />

Extracorporeal Membrane Oxygenation and Cardiopulmonary Resuscitation on Norwood Procedure<br />

Outcomes: Data from the Single Ventricle Reconstruction Trail [Abstract]. Circulation, 124, A9897.<br />

6. Tabbutt S, Ghanayem N, Cooper DS, <strong>Frank</strong> DU, Lu Minmin, Frommelt P, Lai WW, Goldberg C,<br />

Graham EM, Krawczeski C, Mahony L, Ravishankar C, Sleeper LA, Kirsh JA, Lewis AB, Lodge AJ,<br />

Ohye RG, Pizarro C, Simsic J, Spurrier E, Stylianou M, Laussen P for the Pediatric Heart Network<br />

Investigators. (2011). Risk Factors for Hospital Mortality and Morbidity Following the Norwood<br />

Procedure: Results from the Multicenter Single Ventricle Reconstruction Trial [Abstract].<br />

Circulation, 124, A8160.<br />

7. Goldberg CS, Lu M, Mahle WT, Gaynor JW, Williams I, Mussatto KA, Ohye RG, <strong>Frank</strong> D, Graham<br />

EM, Jacobs JP, Krawczeski CD, Lambert L, Lewis A, Pemberton VL, Sananes R, Sood E, Wechsler<br />

S, Newburger JW. (2012). Factors Associated with Impaired Neurodevelopment at 3 Years <strong>of</strong> Age in<br />

Children with Single Right Ventricle Lesions [Abstract]. Circulation, 126, A13230.<br />

8. Riehle C, Wende AR, Sena S, Alambert RP, Pires KM, Bevins J, Zhu Y, Bugger H, <strong>Frank</strong> D, Peryr-<br />

Garza CN, Gottlieb RA, Abel ED. (2012). Insulin Receptor Substrates (IRS) are Essential Regulators<br />

<strong>of</strong> Autophage and Mitochondrial Function in the Heart [Abstract]. Circulation, 126.<br />

UNPUBLISHED POSTER PRESENTATIONS<br />

1. <strong>Frank</strong> DU, and AM Moon. (2002). Fibroblast growth factor 8 is required for normal fourth<br />

pharyngeal arch artery development in mice. Poster session presented at 2002 Weinstein<br />

Cardiovascular Development Conference, Salt Lake City, UT.<br />

2. Macatee, TL, BR Arenkiel, BP Hammond, <strong>Frank</strong> DU, and AM Moon. (2003). Fgf8 has domainspecific<br />

functions during cardiovascular and pharyngeal development. Poster session presented at<br />

Weinstein Cardiovascular Development Conference, Boston, MA.<br />

3. <strong>Frank</strong> DU and AM Moon. (2005). Developmental echocardiography <strong>of</strong> the fgf8 deficient fetal<br />

<strong>Frank</strong>, Page 7


mouse. Poster session presented at 2005 Weinstein Cardiovascular Development Conference, Tuscon,<br />

AZ.<br />

4. <strong>Frank</strong> DU, E-J Park, S Elliott, Y Saijoh, and AM Moon. (2006). Inducible expression <strong>of</strong> Cre<br />

recombinase in endoderm and notochord. Poster session presented at 2006 Weinstein Cardiovascular<br />

Development Conference, St. Petersburg, FL.<br />

5. <strong>Frank</strong> DU, LA Ogden, AB Firuilli, and AM Moon. (2007). Arrythmias cause embryonic lethality in<br />

Tbx3 mutant mice. Poster session presented at Weinstein Cardiovascular Development Conference,<br />

Indianapolis, IN.<br />

ORAL PRESENTATIONS<br />

Meeting Presentations (Not Published Abstracts and Not Unpublished Posters)<br />

Local/Regional<br />

1998 <strong>Frank</strong>, DU and GF Rich. Regulation <strong>of</strong> the endogenous NO pathway by prolonged hypoxia and<br />

inhaled NO in rats. Pediatric Research in Progress, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>.<br />

2002 <strong>Frank</strong>, DU, and AM Moon. The role <strong>of</strong> fibroblast growth factor 8 in mouse cardiovascular<br />

development. Pediatric Research in Progress, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>.<br />

2005 <strong>Frank</strong>, DU, and AM Moon. Developmental echocardiography in Fgf8 conditionally mutant mice.<br />

Pediatric Research in Progress, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>.<br />

2007 <strong>Frank</strong>, DU, and AM Moon. Exploring Relationships between form and function during<br />

cardiogenesis: Studies using fgf8 mutant models. Pediatric Research in Progress, <strong>University</strong> <strong>of</strong><br />

<strong>Utah</strong>.<br />

2007 <strong>Frank</strong>, DU, and AM Moon. Tbx3 is required for normal development <strong>of</strong> cardiac rhythm and<br />

structure. Pediatric Research in Progress, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>.<br />

2008 <strong>Frank</strong>, DU, and AM Moon. Embryonic arrhythmias in Tbx3 hypomorphic mice: a model for<br />

studying conduction system development. Molecular Medicine Program and MD/<strong>Ph</strong>D Program<br />

Retreat, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, Park City, UT.<br />

2008 <strong>Frank</strong>, DU, and AM Moon. Embryonic arrhythmias in Tbx3 hypomorphic mice: a model for<br />

studying conduction system development. Pediatric Research in Progress, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>.<br />

Invited/Visiting Pr<strong>of</strong>essor Presentations<br />

National<br />

2009 <strong>Frank</strong>, DU and AM Moon. Tbx3 Gene Dosage Affects Function <strong>of</strong> the Developing Cardiac<br />

Conduction System. Pediatric Critical Care Scientist Development Program Symposium, Pediatric<br />

Academic Societies Annual Meeting, Baltimore, MD.<br />

2010 <strong>Frank</strong>, DU. Update on Animal Models <strong>of</strong> Congenital Heart Disease. 18th <strong>Utah</strong> Conference on<br />

Congenital Cardiovascular Disease, Snowbird, UT<br />

OTHER SCHOLARLY ACTIVITY<br />

Clinical Studies<br />

2002 - 2005 Co-Investigator. Trial <strong>of</strong> Pulse Steroid Therapy in Kawasaki Disease. Pediatric Heart<br />

Research Network, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>. PI: LuAnn Minich, MD<br />

2010 - Present Data Safety Monitoring Board Member. <strong>Ph</strong>ase I : A Pilot Study <strong>of</strong> the Safety and<br />

Efficacy <strong>of</strong> Oxandrolone in the Prevention and Treatment <strong>of</strong> Malnutrition in Infants<br />

after Cardiac Surgery. PI: <strong>Ph</strong>illip Burch, MD<br />

2010 - 2012 Co-Investigator. Predication <strong>of</strong> Feeding Problems in Prostaglandin-dependent<br />

Prematurely Born Infants with Congenital Heart Disease. PI Christian Yost, MD.<br />

<strong>Frank</strong>, Page 8


Closed due to inadequate enrollment.<br />

2012 - Present Quality Improvement Project, Reducing Blood Testing in the Cardiac ICU, Primary<br />

Children's Medical Center, Salt Lake City, UT. Project Lead: Claudia Delgado-<br />

Cocoran, MD.<br />

2013 - Present Cardiac Working Group Member, THAPCA (Therapeutic Hypothermia After<br />

Pediatric Cardiac Arrest) Trial. <strong>University</strong> <strong>of</strong> <strong>Utah</strong> PI: Kimberly Bennett, MD.<br />

<strong>Frank</strong>, Page 9

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