Deborah U. Frank, M.D., Ph.D. - Pediatrics - University of Utah
Deborah U. Frank, M.D., Ph.D. - Pediatrics - University of Utah
Deborah U. Frank, M.D., Ph.D. - Pediatrics - University of Utah
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Curriculum Vitae Last Updated: 08/08/2013<br />
PERSONAL DATA<br />
Name: <strong>Deborah</strong> U. <strong>Frank</strong><br />
Birth Place: Red Bank, New Jersey<br />
Citizenship: United States<br />
Added to the file by faculty request 8/20/13.<br />
EDUCATION<br />
Years Degree Institution (Area <strong>of</strong> Study)<br />
1987 - 1991 B.S. Northwestern <strong>University</strong> (Biomedical Engineering)<br />
Evanston, IL<br />
1991 - 1998 M.D. <strong>University</strong> <strong>of</strong> Virginia, School <strong>of</strong> Medicine (Medicine)<br />
Charlottesville, VA<br />
1993 - 1997 <strong>Ph</strong>.D. <strong>University</strong> <strong>of</strong> Virginia, School <strong>of</strong> Engineering and Applied<br />
Science (Biomedical Engineering)<br />
Charlottesville, VA<br />
1998 - 2001 Resident <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, School <strong>of</strong> Medicine (<strong>Pediatrics</strong>)<br />
Salt Lake City, UT<br />
2001 - 2006 Postdoctoral Fellow <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, Human Molecular Biology and Genetics<br />
(Cardiac Development)<br />
Salt Lake City, UT<br />
2001 - 2004 Fellow <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, School <strong>of</strong> Medicine (Pediatric Cardiology)<br />
Salt Lake City, UT<br />
2004 - 2006 Fellow <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, School <strong>of</strong> Medicine (Pediatric Critical Care)<br />
Salt Lake City, UT<br />
2004 - 2006 Visiting Fellow The Children's Hospital <strong>of</strong> <strong>Ph</strong>iladelphia (Pediatric Cardiac<br />
Intensive Care)<br />
<strong>Ph</strong>iladelphia, PA<br />
BOARD CERTIFICATIONS<br />
05/01/1999 National Board <strong>of</strong> Medical Examiners, Certified<br />
10/16/2001 American Board <strong>of</strong> <strong>Pediatrics</strong> (<strong>Pediatrics</strong>), Has subspecialty board<br />
08/16/2004 American Board <strong>of</strong> <strong>Pediatrics</strong> (Sub: Ped Cardiology), Certified<br />
08/18/2006 American Board <strong>of</strong> <strong>Pediatrics</strong> (Sub: Crit Care Med), Certified<br />
CURRENT LICENSES/CERTIFICATIONS<br />
1998 - 2014 American Heart Association: Pediatric Advanced Life Support (UT) - <strong>Ph</strong>ysician (MD)<br />
2011 - 2013 American Heart Association: Advanced Cardiac Life Support<br />
<strong>Frank</strong>, Page 1
ACADEMIC HISTORY<br />
<strong>Pediatrics</strong> (Pediatric Critical Care)<br />
07/01/2006 Hire, Tenure Track, Instructor<br />
07/01/2009 PromotionAssistant Pr<strong>of</strong>essor<br />
PROFESSIONAL EXPERIENCE<br />
Full Time Positions<br />
2006 - Present Attending <strong>Ph</strong>ysician, Cardiac Intensive Care Unit, Primary Children's Medical<br />
Center, Salt Lake City, <strong>Utah</strong><br />
2006 - 2009 Instructor <strong>of</strong> <strong>Pediatrics</strong>, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, Salt Lake City, <strong>Utah</strong><br />
2009 - Present Assistant Pr<strong>of</strong>essor <strong>of</strong> <strong>Pediatrics</strong>, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, Salt Lake City, <strong>Utah</strong><br />
Part Time Positions<br />
2001 - 2004 Affiliate <strong>Ph</strong>ysician, Intermountain Healthcare, Kidscare, Salt Lake City, UT<br />
SCHOLASTIC HONORS<br />
1989 Tau Beta Pi Engineering Honor Society, Northwestern <strong>University</strong><br />
1991 Northwestern <strong>University</strong>, Dean’s List for all 12 quarters<br />
1991 Northwestern <strong>University</strong>, Graduated with Distinction<br />
1991 - 1998 <strong>University</strong> <strong>of</strong> Virginia, Medical Scientist Training (MD/<strong>Ph</strong>D) Program<br />
1992 <strong>University</strong> <strong>of</strong> Virginia, Merck Manual Award<br />
1993 American Society <strong>of</strong> Clinical Pathologists’ Award for Academic Excellence and<br />
Achievement, <strong>University</strong> <strong>of</strong> Virginia<br />
1993 - 1997 Virginia Engineering Foundation Fellowships, <strong>University</strong> <strong>of</strong> Virginia<br />
1993 Alpha Omega Alpha Medical Honor Society, <strong>University</strong> <strong>of</strong> Virginia<br />
1998 Robert M. Blizzard Pediatric Scholar Award, <strong>University</strong> <strong>of</strong> Virginia<br />
2001 - 2010 Primary Children’s Medical Foundation Scholar, <strong>University</strong> <strong>of</strong> <strong>Utah</strong><br />
2006 - 2008 Cardiovascular Training Grant T-32, Postdoctoral fellow, <strong>University</strong> <strong>of</strong> <strong>Utah</strong><br />
2008 - 2010 Pediatric Critical Care Scientist Development Program Scholar, K12, <strong>University</strong> <strong>of</strong><br />
<strong>Utah</strong><br />
ADMINISTRATIVE EXPERIENCE<br />
Administrative Duties<br />
2011 - Present CICU Faculty Coordinator, Cardioaccess Database, Cardiac Center, Primary<br />
Children's Medical Center<br />
2012 - Present Research Advocacy Group, Cardiac Center, Primary Children's Medical Center<br />
2012 - Present Member, High Risk Program Steering Committee, Cardiac Center, Primary<br />
Children's Medical Center<br />
2012 - Present Member, Infant Feeding Guidlines Committee for the Cardiac Center, Primary<br />
Children's Medical Center<br />
2012 - Present Chair, Technology Committee for the Pediatric and Cardiac Intensive Care Units at<br />
Primary Children's Medical Center<br />
2013 - Present Culture Champion, Cardiac Center, Primary Children's Medical Center<br />
<strong>Frank</strong>, Page 2
PROFESSIONAL COMMUNITY ACTIVITIES<br />
2012 Medical Team Volunteer, Medical Mission, Pediatric Cardiac Intensive Care<br />
<strong>Ph</strong>ysician on mission to hospital Nacional Dos de Mayo, Lima, Peru with the Hearts<br />
with Hope Foundation, Los Angelos, CA<br />
SERVICE AT PREVIOUS INSTITUTIONS<br />
1994 - 1996 Medical Student Member, <strong>University</strong> <strong>of</strong> Virginia, Human Investigation Committee<br />
(IRB)<br />
CURRENT MEMBERSHIPS IN PROFESSIONAL SOCIETIES<br />
American College <strong>of</strong> Cardiology<br />
American College <strong>of</strong> Cardiology - Congenital Heart Disease and Pediatric Cardiology Section<br />
Pediatirc Cardiac Intensive Care Society<br />
Society <strong>of</strong> Critical Care Medicine<br />
Society <strong>of</strong> Critical Care Medicine - <strong>Pediatrics</strong> Section<br />
FUNDING<br />
Active Grants<br />
03/01/13 -<br />
03/01/14<br />
Past Grants<br />
07/01/02 -<br />
07/01/03<br />
11/01/02 -<br />
11/01/04<br />
01/01/08 -<br />
12/31/09<br />
01/01/08 -<br />
12/31/10<br />
Development <strong>of</strong> Translational Techniques to Evaluate Myocardial Enegertics in<br />
Infants with Single Ventricle <strong>Ph</strong>ysiology on Oxandrolone<br />
Principal Investigator: <strong>Deborah</strong> U. <strong>Frank</strong><br />
Direct Costs: $40,000 Total Costs: $40,000<br />
Primary Children's Medical Center Foundation<br />
Role: Principal Investigator<br />
The role <strong>of</strong> FGF8 in mouse cardiovascular development - Innovative Research Grant,<br />
Mentor: Anne M. Moon, M.D., <strong>Ph</strong>.D.<br />
Principal Investigator: <strong>Deborah</strong> U. <strong>Frank</strong><br />
Direct Costs: $25,000 Total Costs: $25,000<br />
Primary Children's Medical Center Foundation<br />
Role: Principal Investigator<br />
Trial <strong>of</strong> Pulse Steroid Therapy in Kawasaki Disease - Grant # 59001261, Pediatric<br />
Heart Research Network, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, Salt Lake City, UT<br />
Principal Investigator: L. LuAnn Minich<br />
National Heart, Lung, and Blood Institute<br />
Role: Co-Investigator<br />
The role <strong>of</strong> Tbx3 in mouse cardiac development<br />
Principal Investigator: <strong>Deborah</strong> U. <strong>Frank</strong><br />
Direct Costs: $37,500 Total Costs: $37,500<br />
Primary Children's Medical Center Foundation<br />
Role: Principal Investigator<br />
Role <strong>of</strong> Tbx3 in Mouse Cardiac Development<br />
Pediatric Critical Care Scientist Development Program K12<br />
Principal Investigator: <strong>Deborah</strong> U. <strong>Frank</strong><br />
National Institutes <strong>of</strong> Health<br />
Role: Principal Investigator<br />
02/01/09 - Role Of Tbx3 In Mouse Cardiac Development<br />
<strong>Frank</strong>, Page 3
01/31/11 Principal Investigator: <strong>Deborah</strong> U. <strong>Frank</strong><br />
Direct Costs: $136,364 Total Costs: $150,000<br />
March <strong>of</strong> Dimes Foundation<br />
Role: Principal Investigator<br />
TEACHING RESPONSIBILITIES/ASSIGNMENTS<br />
Clinical Teaching<br />
2004 Pediatric Cardiology Fellowship Lecture Series, Myocarditis and Pericarditis<br />
2005 - Present Pediatric Critical Care Fellowship Lecture Series, Echocardiography for ICU<br />
physicians, presented every 2 - 3 years<br />
2005 - 2011 Pediatric Critical Care Fellowship Lecture Series, Staged Palliation <strong>of</strong> Single<br />
Ventricle Lesions, annually<br />
2005 Pediatric Critical Care Fellowship Lecture Series, Clinical Practice Review, CPR<br />
2006 Pediatric Critical Care Fellowship Lecture Series, Clinical Practice Review, ECMO<br />
during and after CPR<br />
2006 Pediatric Cardiology Fellowship Lecture Series, Cardiac Anatomy<br />
2007 Pediatic Resident Noon Lecture, Cardiac Emergencies<br />
2007 Pediatric Cardiology Fellowship Lecture Series, Post-operative Care: Monitoring<br />
Hemodynamics<br />
2009 Pediatric Cardiology Fellowship Lecture Series, Update in Cardiac Intensive Care<br />
2009 Pediatric Resident Noon Lecture, Myocarditis<br />
2011 Pediatric Cardiology Fellowship Lecture Series, Basics <strong>of</strong> Cardiac Intensive Care<br />
2011 - 2012 Pediatric Critical Care Fellowship Lecture Series, Cardiac <strong>Ph</strong>ysiology<br />
Small Group Teaching<br />
2011 - Present Pediatric Cardiology Fellows Board Preparation Sessions - Topic: Cardiac Intensive<br />
Care. Taught during every 3 year cycle. 10/2011, 2/2013.<br />
Trainee Supervision<br />
Fellow<br />
2009 - 2012 Advisor/Mentor, Titus Chan, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>. Scholarship Oversight Committee<br />
2011 - 2013 Advisor/Mentor, Brook Lang, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>. Scholarship Oversight Committee<br />
2013 - 2015 Advisor/Mentor, Hillary Crandal, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>. Scholarship Oversight<br />
Committee<br />
Medical Student<br />
2011 - Present Advisor/Mentor, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>. 2nd year Medical Student Clinical Shadowing<br />
Undergraduate<br />
2005 - 2006 Supervisor, Sarah Elliott, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>. Laboratory Research<br />
Trainee's Current Career Activities: Graduate Student, <strong>University</strong> <strong>of</strong> <strong>Utah</strong><br />
2008 - 2009 Supervisor, Michael Burr, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>. Laboratory Research<br />
Trainee's Current Career Activities: Researcher at Moran Eye Institute<br />
Educational Lectures<br />
Didactic Lectures<br />
2004 Echocardiography for ICU nurses, Pediatric ICU Cardiac Nursing Lecture,<br />
Primary Children's Medical Center, Salt lake City, UT<br />
2007 Stage I Palliation <strong>of</strong> HLHS: BT vs. Sano Shunt. Pediatric ICU Cardiac Nurses<br />
Symposium, Primary Children’s Medical Center, Salt Lake City, UT<br />
2007 Cardiac Assessment. Cardiovascular Nurses Training, Primary Children’s<br />
Medical Center, Salt Lake City, UT<br />
<strong>Frank</strong>, Page 4
Continuing Education<br />
CE Courses Taught<br />
2012 - Present Congenital Core Curriculum Review, Cardiovascular & Thoracic Surgery,<br />
Intermountain Healthcare Continuing Medical Education, Lecutre on Cardiac<br />
Intensive Care and Monitoring for Surgeons preparing for Board Exams. 2012<br />
was inital course year, with 6 attendees.<br />
PEER-REVIEWED JOURNAL ARTICLES<br />
1. Rich, GF, CM Roos, SM Anderson, Urich DC, MO Daugherty, RA Johns. (1993). Inhaled nitric<br />
oxide: dose response and the effects <strong>of</strong> blood in the isolated rat lung. J Appl <strong>Ph</strong>ysiol, 75, 1278-1284.<br />
2. Roos CM, Rich GF, Uncles DR, Daugherty MO, <strong>Frank</strong> DU. (1994). Sites <strong>of</strong> vasodilation by inhaled<br />
nitric oxide vs. sodium nitroprusside in endothelin-constricted isolated rat lungs. J Appl<br />
<strong>Ph</strong>ysiol, 77(1), 51-7.<br />
3. Roos CM, <strong>Frank</strong> DU, Xue C, Johns RA, Rich GF. (1996). Chronic inhaled nitric oxide: effects on<br />
pulmonary vascular endothelial function and pathology in rats. J Appl <strong>Ph</strong>ysiol, 80(1), 252-60.<br />
4. <strong>Frank</strong> DU, Lowson SM, Roos CM, Rich GF. (1996). Endotoxin alters hypoxic pulmonary<br />
vasoconstriction in isolated rat lungs. J Appl <strong>Ph</strong>ysiol, 81(3), 1316-22.<br />
5. Uncles DR, Daugherty MO, <strong>Frank</strong> DU, Roos CM, Rich GF. (1996). Nitric oxide modulation <strong>of</strong><br />
pulmonary vascular resistance is red blood cell dependent in isolated rat lungs. Anesth<br />
Analg, 83(6), 1212-7.<br />
6. Horstman DJ, <strong>Frank</strong> DU, Rich GF. (1998). Prolonged inhaled NO attenuates hypoxic, but not<br />
monocrotaline-induced, pulmonary vascular remodeling in rats. Anesth Analg, 86(1), 74-81.<br />
7. <strong>Frank</strong> DU, Horstman DJ, Morris GN, Johns RA, Rich GF. (1998). Regulation <strong>of</strong> the endogenous<br />
NO pathway by prolonged inhaled NO in rats. J Appl <strong>Ph</strong>ysiol, 85(3), 1070-8.<br />
8. <strong>Frank</strong> DU, Horstman DJ, Rich GF. (1998). The effect <strong>of</strong> prolonged inhaled nitric oxide on<br />
pulmonary vasoconstriction in rats. Anesth Analg, 87(6), 1285-90.<br />
9. Horstman DJ, McCall DA, <strong>Frank</strong> DU, Rich GF. (1999). Inhaled nitric oxide and nifedipine have<br />
similar effects on lung cGMP levels in rats. Anesth Analg, 89(4), 932-7.<br />
10. <strong>Frank</strong> DU, Fotheringham LK, Brewer JA, Muglia LJ, Tristani-Firouzi M, Capecchi MR, Moon AM.<br />
(2002). An Fgf8 mouse mutant phenocopies human 22q11 deletion syndrome.<br />
Development, 129(19), 4591-603.<br />
11. <strong>Frank</strong> DU, Minich LL, Shaddy RE, Tani LY. (2002). Is Doppler an accurate predictor <strong>of</strong><br />
catheterization gradients for postoperative branch pulmonary stenosis? J Am Soc<br />
Echocardiogr, 15(10 Pt 2), 1140-4.<br />
12. Macatee TL, Hammond BP, Arenkiel BR, Francis L, <strong>Frank</strong> DU, Moon AM. (2003). Ablation <strong>of</strong><br />
specific expression domains reveals discrete functions <strong>of</strong> ectoderm- and endoderm-derived FGF8<br />
during cardiovascular and pharyngeal development. Development, 130(25), 6361-74.<br />
13. Park EJ, Ogden LA, Talbot A, Evans S, Cai CL, Black BL, <strong>Frank</strong> DU, Moon AM. (2006).<br />
Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling.<br />
Development, 133(12), 2419-33.<br />
14. <strong>Frank</strong> DU, Elliott SA, Park EJ, Hammond J, Saijoh Y, Moon AM. (2007). System for inducible<br />
expression <strong>of</strong> cre-recombinase from the Foxa2 locus in endoderm, notochord, and floor plate. Dev<br />
Dyn, 236(4), 1085-92.<br />
15. Chan T, Thiagarajan RR, <strong>Frank</strong> D, Bratton SL. (2008). Survival after extracorporeal<br />
cardiopulmonary resuscitation in infants and children with heart disease. J Thorac Cardiovasc<br />
Surg, 136(4), 984-92.<br />
16. Printz BF, Sleeper LA, Newburger JW, Minich LL, Bradley T, Cohen MS, <strong>Frank</strong> D, Li JS,<br />
Margossian R, Shirali G, Takahashi M, Colan SD. (2011). Noncoronary cardiac abnormalities are<br />
associated with coronary artery dilation and with laboratory inflammatory markers in acute<br />
<strong>Frank</strong>, Page 5
Kawasaki disease. J Am Coll Cardiol, 57(1), 86-92.<br />
17. <strong>Frank</strong> DU, Carter KL, Thomas KR, Burr RM, Bakker ML, Coetzee WA, Tristani-Firouzi M,<br />
Bamshad MJ, Christ<strong>of</strong>fels VM, Moon AM. (2012). Lethal arrhythmias in Tbx3-deficient mice reveal<br />
extreme dosage sensitivity <strong>of</strong> cardiac conduction system function and homeostasis. Proc Natl Acad<br />
Sci U S A, 109(3), E154-63.<br />
18. Ohye RG, Shonbeck JV, Eghtesady P, Laussen PC, Pizarro C, Shrader P, <strong>Frank</strong> DU, Graham EM,<br />
Hill KD, Jacobs JP, Kanter KR, Kirsch JA, Lambert LM, Lewis AB, Ravishankar C, Tweddell JS,<br />
Williams IA, Pearson GD, for the Pediatric Heart Network Investigators. (2012). Cause, Timing and<br />
Location <strong>of</strong> Death in the Single Ventricle Reconstruction Trial. J Thorac Cardiovasc<br />
Surg, 144(4), 907-14.<br />
19. Tabbutt S, Ghanayem N, Ravishankar C, Sleeper LA, Cooper DS, <strong>Frank</strong> DU, Lu M, Pizarro C,<br />
Frommelt P, Goldberg CS, Graham EM, Krawczeski CD, Lai WW, Lewis A, Kirsh JA, Mahony L,<br />
Ohye RG, Simsic J, Lodge AJ, Spurrier E, Stylianou M, Laussen P, Pediatric Heart Network<br />
Investigators. (2012). Risk factors for hospital morbidity and mortality after the Norwood procedure:<br />
A report from the Pediatric Heart Network Single Ventricle Reconstruction trial. J Thorac<br />
Cardiovasc Surg, 144(4), 882-95.<br />
20. <strong>Frank</strong> DU, Emechebe U, Thomas KR, Moon AM. (2013). Mouse tbx3 mutants suggest novel<br />
molecular mechanisms for ulnar-mammary syndrome. PLoS ONE, 8(7), e67841.<br />
OTHER (Commentary/Letters/Editorials/Case Reports/Video/Film)<br />
Commentary<br />
1. <strong>Frank</strong> D. (2010). Shunt Type in the Norwood Procedure. AAP Grand Rounds, 24(3), 34.<br />
Editorials<br />
1. <strong>Frank</strong> DU, Bratton SL. (2010). What's new in extracorporeal cardiopulmonary resuscitation? Pediatr<br />
Crit Care Med, 11(3), 429-31.<br />
PENDING PUBLICATIONS<br />
Journal Articles<br />
1. Goldberg CS, Lu M, Sleeper LA, Mahle WT, Gaynor JW, Williams IA, Mussatto KA, Ohye RG,<br />
Graham EM, <strong>Frank</strong> DU, Jacobs JP, Krawczeski C, Lambert L, Lewis A, Pemberton VL, Sananes R,<br />
Sood E, Wechsler SB, Newburger JW. (In Revision). Factors Associated with Neurodevelopment for<br />
Children with Single Ventricle Lesions. J Pediatr.<br />
2. Riehle C, Wende AR, Sena S, Pires KM, Pereira-Alambert R, Zhu Y, Bugger H, <strong>Frank</strong> D, Bevins J,<br />
Chen D, Perry-Garza CN, Dong X, Valdez S, Sheng X, Weimer BC, Gottlieb RA, White MF, Abel<br />
ED. (Under Review). Insulin Receptor Substrates are Required for Supressing Neonatal Autophagy in<br />
the Heart. J Clin Invest.<br />
Abstracts<br />
1. Delgado-Corcoran C, Bodily S, <strong>Frank</strong> D, Bratton S. (In Press). Reducing Blood Testing in Pediatric<br />
Patients after Heart Surgery [Abstract]. Pediatric Cardiac Intensive Care Society, 9th International<br />
Conference, December 2012, Miami Beach, FL.<br />
<strong>Frank</strong>, Page 6
Case Reports<br />
1. Bogarapu S, Bleyl SB, Calhoun A, Viskochil DH, Saarel EV, Everitt MD, <strong>Frank</strong> DU. (Submitted).<br />
<strong>Ph</strong>enotype <strong>of</strong> a Patient with Contiguous Deletion <strong>of</strong> TBX5 and TBX3: Expanding the Disease<br />
Spectrum. Am J Hum Genet.<br />
RECENTLY PUBLISHED ABSTRACTS (Last 3 Years)<br />
1. Null D, Bierer R, Dahl M, Jones C, Block C, Jensen S, Wimmer J, Leavitt T, McCoy N, Von Der Ahe<br />
N, Alvord J, Houston D, Dong L, <strong>Frank</strong> D, DiGeronimo R, Yoder B, Albertine K. (2011). IGF-1 and<br />
Caspase 3 Expression Modifications in the Lung and Brain in a ECMO Model Using Term Lambs<br />
[Abstract]. E-PAS2011592.<br />
2. Bierer R, Null D, Dahl M, Jones C, Block C, Jensen S, Wimmer J, Leavitt T, McCoy M, Von Der Ahe<br />
N, Alvord J, Houston B, Dong L, <strong>Frank</strong> D, Digeronimo R, Yoder B, Albertine K. (2011). Stretch,<br />
Rather than Oxygen Exposure, Change Molecular Expression in the Lung in an ECMO Model Using<br />
Term Lambs [Abstract]. E-PAS2011591.<br />
3. Kosaka Y, Lezin G, Gittenberger-de Groot AC, Saijoh Y, <strong>Frank</strong> D, Wisse LJ, Toyo-oka K,<br />
Wynshaw-Boris A, Yost HJ, Brunelli L. (2011). Deletion <strong>of</strong> 14-3-3ε in Mice Leads to Tricuspid<br />
Abnormalities and Gerbode Defect [Abstract]. E-PAS2011:2830.1.<br />
4. Ohye RG, Schonbeck JV, Eghtesady P, Laussen PC, Pizarro C, Shrader P, <strong>Frank</strong> DU, Graham EM,<br />
Hill KD, Jacobs JP, Kanter KR, Kirsh JA, Lambert LM, Lewis AB, Ravishankar C, Tweddell JS,<br />
Williams IA, Pearson GD, for the Pediatric Heart Network Investigators. (2011). Cause, Timing and<br />
Location <strong>of</strong> Death in the Single Ventricle Reconstruction Trial [Abstract]. Circulation, 124, A10098.<br />
5. Ravishankar C, Tabbutt S, Allen K, Cooper DS, <strong>Frank</strong> DU, Frommelt P, Ghanayem N, Goldberg K,<br />
Graham EM, Kirsh JA, Krawczeski C, Lai WW, Lewis AB, Lodge AJ, Mahony L, Simsic J, Sleeper<br />
LA, Stylianou M, Wang Y, Laussen P for the Pediatric Heart Network Investigators. (2011). Impact <strong>of</strong><br />
Extracorporeal Membrane Oxygenation and Cardiopulmonary Resuscitation on Norwood Procedure<br />
Outcomes: Data from the Single Ventricle Reconstruction Trail [Abstract]. Circulation, 124, A9897.<br />
6. Tabbutt S, Ghanayem N, Cooper DS, <strong>Frank</strong> DU, Lu Minmin, Frommelt P, Lai WW, Goldberg C,<br />
Graham EM, Krawczeski C, Mahony L, Ravishankar C, Sleeper LA, Kirsh JA, Lewis AB, Lodge AJ,<br />
Ohye RG, Pizarro C, Simsic J, Spurrier E, Stylianou M, Laussen P for the Pediatric Heart Network<br />
Investigators. (2011). Risk Factors for Hospital Mortality and Morbidity Following the Norwood<br />
Procedure: Results from the Multicenter Single Ventricle Reconstruction Trial [Abstract].<br />
Circulation, 124, A8160.<br />
7. Goldberg CS, Lu M, Mahle WT, Gaynor JW, Williams I, Mussatto KA, Ohye RG, <strong>Frank</strong> D, Graham<br />
EM, Jacobs JP, Krawczeski CD, Lambert L, Lewis A, Pemberton VL, Sananes R, Sood E, Wechsler<br />
S, Newburger JW. (2012). Factors Associated with Impaired Neurodevelopment at 3 Years <strong>of</strong> Age in<br />
Children with Single Right Ventricle Lesions [Abstract]. Circulation, 126, A13230.<br />
8. Riehle C, Wende AR, Sena S, Alambert RP, Pires KM, Bevins J, Zhu Y, Bugger H, <strong>Frank</strong> D, Peryr-<br />
Garza CN, Gottlieb RA, Abel ED. (2012). Insulin Receptor Substrates (IRS) are Essential Regulators<br />
<strong>of</strong> Autophage and Mitochondrial Function in the Heart [Abstract]. Circulation, 126.<br />
UNPUBLISHED POSTER PRESENTATIONS<br />
1. <strong>Frank</strong> DU, and AM Moon. (2002). Fibroblast growth factor 8 is required for normal fourth<br />
pharyngeal arch artery development in mice. Poster session presented at 2002 Weinstein<br />
Cardiovascular Development Conference, Salt Lake City, UT.<br />
2. Macatee, TL, BR Arenkiel, BP Hammond, <strong>Frank</strong> DU, and AM Moon. (2003). Fgf8 has domainspecific<br />
functions during cardiovascular and pharyngeal development. Poster session presented at<br />
Weinstein Cardiovascular Development Conference, Boston, MA.<br />
3. <strong>Frank</strong> DU and AM Moon. (2005). Developmental echocardiography <strong>of</strong> the fgf8 deficient fetal<br />
<strong>Frank</strong>, Page 7
mouse. Poster session presented at 2005 Weinstein Cardiovascular Development Conference, Tuscon,<br />
AZ.<br />
4. <strong>Frank</strong> DU, E-J Park, S Elliott, Y Saijoh, and AM Moon. (2006). Inducible expression <strong>of</strong> Cre<br />
recombinase in endoderm and notochord. Poster session presented at 2006 Weinstein Cardiovascular<br />
Development Conference, St. Petersburg, FL.<br />
5. <strong>Frank</strong> DU, LA Ogden, AB Firuilli, and AM Moon. (2007). Arrythmias cause embryonic lethality in<br />
Tbx3 mutant mice. Poster session presented at Weinstein Cardiovascular Development Conference,<br />
Indianapolis, IN.<br />
ORAL PRESENTATIONS<br />
Meeting Presentations (Not Published Abstracts and Not Unpublished Posters)<br />
Local/Regional<br />
1998 <strong>Frank</strong>, DU and GF Rich. Regulation <strong>of</strong> the endogenous NO pathway by prolonged hypoxia and<br />
inhaled NO in rats. Pediatric Research in Progress, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>.<br />
2002 <strong>Frank</strong>, DU, and AM Moon. The role <strong>of</strong> fibroblast growth factor 8 in mouse cardiovascular<br />
development. Pediatric Research in Progress, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>.<br />
2005 <strong>Frank</strong>, DU, and AM Moon. Developmental echocardiography in Fgf8 conditionally mutant mice.<br />
Pediatric Research in Progress, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>.<br />
2007 <strong>Frank</strong>, DU, and AM Moon. Exploring Relationships between form and function during<br />
cardiogenesis: Studies using fgf8 mutant models. Pediatric Research in Progress, <strong>University</strong> <strong>of</strong><br />
<strong>Utah</strong>.<br />
2007 <strong>Frank</strong>, DU, and AM Moon. Tbx3 is required for normal development <strong>of</strong> cardiac rhythm and<br />
structure. Pediatric Research in Progress, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>.<br />
2008 <strong>Frank</strong>, DU, and AM Moon. Embryonic arrhythmias in Tbx3 hypomorphic mice: a model for<br />
studying conduction system development. Molecular Medicine Program and MD/<strong>Ph</strong>D Program<br />
Retreat, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>, Park City, UT.<br />
2008 <strong>Frank</strong>, DU, and AM Moon. Embryonic arrhythmias in Tbx3 hypomorphic mice: a model for<br />
studying conduction system development. Pediatric Research in Progress, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>.<br />
Invited/Visiting Pr<strong>of</strong>essor Presentations<br />
National<br />
2009 <strong>Frank</strong>, DU and AM Moon. Tbx3 Gene Dosage Affects Function <strong>of</strong> the Developing Cardiac<br />
Conduction System. Pediatric Critical Care Scientist Development Program Symposium, Pediatric<br />
Academic Societies Annual Meeting, Baltimore, MD.<br />
2010 <strong>Frank</strong>, DU. Update on Animal Models <strong>of</strong> Congenital Heart Disease. 18th <strong>Utah</strong> Conference on<br />
Congenital Cardiovascular Disease, Snowbird, UT<br />
OTHER SCHOLARLY ACTIVITY<br />
Clinical Studies<br />
2002 - 2005 Co-Investigator. Trial <strong>of</strong> Pulse Steroid Therapy in Kawasaki Disease. Pediatric Heart<br />
Research Network, <strong>University</strong> <strong>of</strong> <strong>Utah</strong>. PI: LuAnn Minich, MD<br />
2010 - Present Data Safety Monitoring Board Member. <strong>Ph</strong>ase I : A Pilot Study <strong>of</strong> the Safety and<br />
Efficacy <strong>of</strong> Oxandrolone in the Prevention and Treatment <strong>of</strong> Malnutrition in Infants<br />
after Cardiac Surgery. PI: <strong>Ph</strong>illip Burch, MD<br />
2010 - 2012 Co-Investigator. Predication <strong>of</strong> Feeding Problems in Prostaglandin-dependent<br />
Prematurely Born Infants with Congenital Heart Disease. PI Christian Yost, MD.<br />
<strong>Frank</strong>, Page 8
Closed due to inadequate enrollment.<br />
2012 - Present Quality Improvement Project, Reducing Blood Testing in the Cardiac ICU, Primary<br />
Children's Medical Center, Salt Lake City, UT. Project Lead: Claudia Delgado-<br />
Cocoran, MD.<br />
2013 - Present Cardiac Working Group Member, THAPCA (Therapeutic Hypothermia After<br />
Pediatric Cardiac Arrest) Trial. <strong>University</strong> <strong>of</strong> <strong>Utah</strong> PI: Kimberly Bennett, MD.<br />
<strong>Frank</strong>, Page 9