Candida Infection Biology – fungal armoury, battlefields ... - FINSysB
Candida Infection Biology – fungal armoury, battlefields ... - FINSysB
Candida Infection Biology – fungal armoury, battlefields ... - FINSysB
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C-type lectin receptor signaling in innate anti-<strong>fungal</strong><br />
immunity<br />
Jürgen Ruland<br />
Institute for Molecular Immunology, Technical University Munich, Germany<br />
Dectin-1 was the first C-type lectin receptor (CLRs) identified to be important in<br />
innate anti-<strong>fungal</strong> immunity. This receptor couples to the tyrosine kinase Syk and<br />
thereby triggers its own intra cellular signaling pathways for inflammatory responses<br />
and host defence. Futher CLRs that can activate Syk and which mediate <strong>fungal</strong><br />
recognition are Dectin-2 and Mincle. Here we will discuss new insights into the<br />
molecular mechanisms of CLR signaling and how they relate to anti-<strong>fungal</strong> defence.<br />
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