Chapter 4 Results - etheses Repository

Figure 49 Forest plots of likelihood ratios (LR’s) of the accuracy of mid-trimester maternal serum CRP
level measurement in asymptomatic women for predicting spontaneous preterm birth before 37 weeks’
gestation*+
Study
0.1 0.2 0.5 1 2
Likelihood ratio for negative test
LR-
(95% CI) % Weight
Ruckhaberle 0.77 ( 0.65, 0.91) 25.3
Hvilsom 0.86 ( 0.76, 0.99) 41.5
Karinen 0.84 ( 0.73, 0.98) 33.2
Overall 0.83 ( 0.76, 0.91)100.0
*χ2 heterogeneity test p = 0.59 for LR+ and p = 0.55 for LR-
+Studies are arranged in descending order of methodological quality
101
LR+
0.5 1 2 5 10
Likelihood ratio for positive test
(95% CI) % Weight
2.06 ( 1.29, 3.29) 23.2
1.81 ( 1.17, 2.78) 27.4
1.55 ( 1.12, 2.13) 49.4
1.72 ( 1.38, 2.16)100.0
Figure 50 Forest plots of likelihood ratios (LR’s) of the accuracy of maternal serum CRP level
measurement in symptomatic women with threatened labour for predicting spontaneous preterm birth
within 7 days of testing*+
Study
0.1 0.2 0.5 1 2
Likelihood ratio for negative test
LR-
(95% CI) % Weight
Cammu 0.19 ( 0.05, 0.65) 23.4
Handwerker 0.17 ( 0.05, 0.62) 23.2
Winkler 0.89 ( 0.69, 1.15) 28.9
Doods 0.21 ( 0.07, 0.63) 24.5
Overall 0.30 ( 0.08, 1.15)100.0
*χ2 heterogeneity test p = 0.0017 for LR+ and p = 0.00021 for LR-
+Studies are arranged in descending order of methodological quality
0.5 1 2 5 10
Likelihood ratio for positive test
LR+
(95% CI) % Weight
34.36 ( 4.86, 243.09) 16.4
7.83 ( 3.01, 20.32) 26.5
1.35 ( 0.71, 2.55) 29.6
2.97 ( 1.27, 6.95) 27.6
4.54 ( 1.48, 13.91) 100.0