Cholinergics and Anticholinergics

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Atropine Atropine is an alkaloid found in atropa belladona It is a competitive antagonist for the muscarinic acetylcholine receptor Because it’s a tertiary amine atropine is relatively lipid soluble <strong>and</strong> cross BBB <strong>and</strong> it’s well distributed through the CNS 30
Atropine continue Duration of action is 4 to 8 hours except in the eyes where it reaches 72 hours or longer initial single doses in adults vary from around 0.5 mg to 1 mg 40% metabolized in the liver,60% excreted un changed in the urine • • • 31
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Page 27: Specific Conditions—Cholinergic v
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Page 52: Glaucoma Glaucoma is increased intr

Cholinergics and Anticholinergics

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