The action potential and the underlying ionic currents
The action potential and the underlying ionic currents
The action potential and the underlying ionic currents
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<strong>The</strong> fast <strong>and</strong> slow delayed rectifier potassium <strong>currents</strong> (I Kr <strong>and</strong> I Ks )<br />
+30 mV<br />
Controll<br />
1 µM E-4031<br />
-40 mV<br />
-80 mV<br />
250 ms<br />
Difference current<br />
E-4031 sensitive (I Kr )<br />
50 pA<br />
Controll<br />
100 nM L-735,821<br />
0 pA<br />
L-735,821 sensitive (I Ks )<br />
200 ms<br />
Varro et al, J.Physiol. 2000; 523.1: 67-81<br />
50 mV<br />
200 ms
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