Annual Report - Central Manchester University Hospitals - NHS ...

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Research Team Helps Children With MPS A stem cell research laboratory for mucopolysaccharide (MPS) diseases is investigating treatments which may help around 400 children in Manchester - and many more nationally. The lab was set up at the Royal Manchester Children’s Hospital by Drs Rob Wynn, Ed Wraith and Brian Bigger. The nine-strong research team is using a multidisciplinary approach to investigate stem cell and gene therapies to improve bone marrow transplantation in MPS and related diseases. MPS diseases are genetic disorders which affect 1 in 26,000 people, mainly children. In each type of the disease, the patient lacks a specific enzyme needed to break down glycosaminoglycans (GAGs), types of carbohydrate that are essential in connective tissues and are used by the body to help cells to communicate with each other. These GAGs are essential for the body to work normally, but when too many build up, as happens in cells from patients with MPS diseases, they cause severe progressive mental decline, heart and other problems as well as bone and joint disease in some cases. Severe forms of MPS usually result in death in early childhood. Milder forms of MPS can be treated with weekly injections of the missing enzyme. However, most severe forms of MPS are currently untreatable as the enzyme supplied in the blood is not able to cross into the brain or to correct bone defects. The exception is Hurler syndrome (MPS IH) which can be treated with a bone marrow transplant. Our team is looking at ways to reduce the risks and side effects involved in bone marrow transplants and to increase success rates. We’re also trying to develop gene therapies for untreatable forms of MPS. Funded by the UK MPS Society and other national MPS and children’s charities, the research group is based in dedicated laboratory facilities at the Royal Manchester Children’s Hospital. (July 2008) Manchester Royal Infirmary Performs First Chimney Procedure In The UK T The Manchester Royal Infirmary became the first hospital in the UK to perform a Chimney (or Periscope) Endovascular aneurysm repair (EVAR). A patient, aged 69, suffered an aortic aneurysm which is when the aorta, the largest artery in the body, balloons or widens. The aneurysm weakens the wall of the artery and can lead to it rupturing which can have fatal consequences. The four hour operation involved a team of three consultants, in addition to many support staff, fitting a ‘chimney’ or ‘periscope’ graft to repair the weakening, instead of the usual stent graft. This had to be used as the area around the aneurysm wasn’t big enough to support the standard stent graft. If they had placed it further up the artery, the blood flow to the patient’s kidneys may have been affected resulting in kidney failure. Without this type of stent, The patient would have had to wait for a minimum of two months for a specially made ‘Branch’ graft from Australia as she was not fit for full conventional surgery. The patient would have been an exceptionally high risk for conventional surgery and because of this new technology they have not only had their aneurysm repaired but their kidney function preserved. Only a few of these chimney grafts have been done world-wide and this was the first in the UK. This new and advanced technique enabled this patient to have the life-saving procedure without a need for a large abdominal incision, therefore reducing the risk of infection and also meaning that a postoperative stay on Intensive care wasn’t needed. Instead, two, much smaller incisions were made in the groin and one in the patient’s armpit. (July 2008) page 6 Central Manchester and Manchester Children’s University Hospitals NHS Trust
Annual Report and Summary Financial Statements 2008/09 page 7 Trust Staff Help Celebrate 60 Years of The NHS To celebrate the NHS 60th Birthday we held an open day which offered not only a look back at yesteryear, but a glance into tomorrow. There was an exhibition highlighting the work and development of all six hospitals within the Trust over the years since they were established and since the beginning of the NHS in 1948. The exhibition not only consisted of an in depth history of the six hospitals in the Trust, but also had features such as the ward diary of a ward sister from 1948 which is a startling contrast to how they work today, 60 minutes in the day of several jobs within the Trust and what was in the news as the NHS reached several milestones. There was also the opportunity to explore the past with the Magical History Tour which look at the existing buildings, which date back over 100 years. It took in interesting features of the old MRI, Saint Mary’s and Eye Hospital site and those on the tour heard about how the hospitals came about and what special events have occurred during the years. The tour of the New Hospitals Development took more than 100 people round the £500 million new hospitals site where they saw how the scheme is progressing. The exhibition and tours were both well attended and the day was a great success. Parrs Wood High School performed a specially commissioned drama production and Chanje Kunda, the Trust’s new Artist in Residence performed some of her own poetry, both to great acclaim. Two large banners hung from the ceiling with the faint outline of a six and a zero. Visitors to the exhibition and those attending the tours were asked to fill in a postcard with their thoughts on what the NHS means to them. (July 2008) Inspirational Leader Appointed For Manchester Health Academy An inspirational head teacher whose leadership resulted in his school being named as the fifth most improved secondary school in England, was appointed as head of one of Manchester’s new academies. Barry Burke, from Chorley, was appointed as the Principal Designate for Manchester Health Academy. The academy, which will be based in Brooklands, Wythenshawe, is one of seven across the city and will provide 600 places for 11-16 year olds and 120 places for 16-19 education. It will specialise in health and will be aimed at students interested in careers in the medical, clinical, nursing and technical health services. The Academy will also develop networks to help further support and influence the health agenda at other schools across the city. Manchester is leading the way with its academy programme in that not only is it ensuring children gain the skills and qualifications demanded by employers, but it is also supported by a comprehensive regeneration programme that is on a scale unlike anywhere else in the country. The Academy is sponsored by the Trust with co-sponsorship from Manchester City Council and The Manchester College. The Academy will differ from existing schools in that sponsors will work alongside teachers to design learning and assessment materials. All students will have personal mentors as well as round the clock access to materials and support to encourage ‘anytime, anywhere learning.’ (July 2008)
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