Methamphetamine - UCLA Integrated Substance Abuse Programs

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Effects of Drugs on Dopamine Release% Basal Release15001000500AccumbensMETHAMPHETAMINE% of Basal Release400300200100AccumbensCOCAINEDADOPACHVA00 1 2 3hrTime After <strong>Methamphetamine</strong>00Time After Cocaine% of Basal Release2502001501000000 11 22 3 hrTime After NicotineNICOTINEAccumbensCaudate% of Basal Release2502001501000AccumbensETHANOLDose (g/kg ip)0.250.512.50 1 2 3 4hrTime After EthanolSource: Shoblock and Sullivan; Di Chiara and Imperato
Decreased dopamine transporterbinding in METH users resembles thatin Parkinson’s s DiseaseControl Meth PDSource: McCann U.D.. et al.,Journal of Neuroscience, 18, pp. 8417-8422, October 15, 1998.
Page 1: Methamphetamine: Modifications in B
Page 10: Respiratory Disorders and MA Use‣
Page 13: In other words:A Major Reason Peopl
Page 22 and 23: Meth
Page 24 and 25: dopaminereservoirsynapse
Page 26 and 27: Prolonged Drug Use ChangesThe Brain
Page 30 and 31: Control> MA43210
Page 32 and 33: Labeling of EmotionBrain scans were
Page 34 and 35: How muchdoes the brain heal?
Page 36 and 37: Partial Recovery of Brain DopamineT
Page 38 and 39: Methamphetamine Use, Self-Reported
Page 40 and 41: Neural Activation Patterns ofMetham
Page 42 and 43: Results Continued‣ 9 areas within
Page 44 and 45: Implications of Results• Neural a
Page 46 and 47: Acute MA Psychosis‣ Extreme Paran
Page 48 and 49: MA Psychosis Inpatients from 4 Coun
Page 50 and 51: MAT-SS Psychiatric andMedical Studi
Page 52 and 53: Study I: Epidemiology of Psychiatri
Page 54 and 55: Association of Diagnoses with Outco
Page 56 and 57: Results: Major Depressive DisorderR
Page 58 and 59: ‣ HypothesesStudy III: Psychotic
Page 60 and 61: ‣ AimStudy IV: Risk Factors for D
Page 62 and 63: ‣ AimStudy V: Risk Factors for Su
Page 64 and 65: Study VI: Medical Illness in MA Use
Page 66 and 67: Prenatal Meth. Exposure‣ Prelimin
Page 68 and 69: My Sexual Pleasure isEnhanced by th
Page 70 and 71: Behavior Symptom Inventory(BSI) Sco
Page 72 and 73: Hepatitis C by Route50454440% Preve
Page 74 and 75: Clinical Challenges with Methamphet
Page 76 and 77: Why the “MA treatment doesn’two
Page 78 and 79:
StatisticsAnalysis of:‣ Drop out
Page 81 and 82:
MA Treatment Issues‣ Acute MA Ove
Page 83 and 84:
Psychostimulant WithdrawalCrash(Day
Page 85 and 86:
Pharmacotherapies for Psychostimula
Page 87 and 88:
Initiating MA Abstinence‣ Key Cli
Page 89 and 90:
Treatment Resources‣ Methamphetmi
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Methamphetamine - UCLA Integrated Substance Abuse Programs

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