Nucleic acids

oxidation• oxidizes the hydroxyl group.• forms a keto group on the β carbon.• reduces NADP +P to NADH.β‐Oxidation of Fatty AcidsIn Reaction 4, fattyacyl CoA is split• between the α and β carbons.• io form Acetyl CoA and a shortened fatty acyl CoA that repeats steps 1 ‐ 4 of β‐oxidation.Cycles of β‐OxidationThe number of β‐Oxidation cycles• depends on the length of a fatty acid.• is one less than the number of acetyl CoA groups formed.Carbons in Acetyl CoA β‐Oxidation CyclesUFatty Acid (C/2) (C/2 –1)12 6 514 7 616 8 7β‐Oxidation and ATP• Activation of a fatty acid requires2 ATP• One cycle of oxidation of a fatty acid produces1 NADH 3 ATP1 FADHB2 B2 ATP• Acetyl CoA entering the citric acid cycle produces1 Acetyl CoA 12 ATPATP for Lauric Acid CB12BATP production for lauric acid (12 carbons):Activation of lauric acid‐2 ATP6 Acetyl CoA6 acetyl CoA x 12 ATP/acetyl CoA 72 ATP5 Oxidation cycles5 NADH x 3 ATP/NADH 15 ATP5 FADH2 x 2 ATP/FADH2 10 ATPTotal95 ATP