Science Cannabis

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Contents1. Introduction, 1The Plant, 4Consumption of Cannabis Preparations for Their PsychoactiveEffects, 14Smoking, 14Eating and Drinking, 17A Brief History, 182. The Pharmacology of THC, the Psychoactive Ingredient inCannabis, 29Man-Made Cannabinoids, 38Structure-Activity Relationships for Cannabinoids, 41Cannabinoid Antagonists, 43How Does THC Get to the Brain? 45Smoking, 45Oral Absorption, 47Other Routes of Administration, 49Elimination of THC from the Body, 50How Does THC Work? 52Discovery of Naturally Occurring Cannabinoids, 58Biosynthesis and Inactivation of Endocannabinoids, 61Interaction of Cannabinoids with Other Chemical Messenger Systemsin the Brain, 63
X/VTHE SCIENCE OF MARIJUANASome Physiological Effects of THC and Anandamide, 65Heart and Blood Vessels, 65Suppression of Immune System Function, 67Sex Hormones and Reproduction, 68Pain Sensitivity, 69Motility and Posture, 72The Billy Martin Tests, 743. The Effects of Cannabis on the Central Nervous System, 77Subjective Reports of the Marijuana High, 78Laboratory Studies of Marijuana in Human Volunteers, 89Effects on Psychomotor Function and Driving, 90Higher Brain Function, Including Learning and Memory, 92Comparisons of Marijuana with Alcohol, 97Where in the Brain Does Marijuana Act? 98Functional Neuroanatomy of Cannabinoid Receptor CB-1 in theBrain, 100What Can Animal Behavior Experiments Tell Us? 102Does Repeated Use of Marijuana Lead to Tolerance andDependence? 1084. Medical Uses of Marijuana—Fact or Fantasy? 121The Modern Revival of Interest in Cannabis-Based Medicines, 131The Synthetic Cannabinoids, 138Dronabinol (Marinol®), 138Nabilone (Cesamet®), 139What are the Medical Targets for Cannabis? 140Nausea and Vomiting Associated with Cancer Chemotherapy, 140AIDS Wasting Syndrome, 147Pain, 150Multiple Sclerosis, 155Glaucoma, 164Epilepsy, 169Bronchial Asthma, 171
Page 2 and 3: The Science°fMarijuana
Page 4 and 5: TheScienceofMarijuanaLeslie L. Iver
Page 6 and 7: ForewordSOLOMON H. SNYDERMore than
Page 8: The Science of Marijuanaviimore dan
Page 11 and 12: XTHE SCIENCE OF MARIJUANAAmerican v
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Page 17 and 18: xviTHE SCIENCE OF MARIJUANASoutheas
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Page 21 and 22: varijuana (cannabis) is among the m
Page 23 and 24: 4 THE SCIENCE OF MARIJUANAin a Lond
Page 25 and 26: 6 THE SCIENCE OF MARIJUANA30 differ
Page 27 and 28: Figure 1.1. Engravings showing the
Page 29: 10 THE SCIENCE OF MARIJUANANameMari
Page 32 and 33: Introduction 13of September Hemp ri
Page 34 and 35: Introduction 15joint has been smoke
Page 36 and 37: Introduction 17this in a normal tob
Page 38 and 39: Introduction 19hemp was cultivated
Page 40 and 41: Introduction 21persuaded Hayder to
Page 42 and 43: Introduction 23were happy about thi
Page 44 and 45: Introduction 25The book captured th
Page 46 and 47: Introduction 27colorful accusations
Page 48 and 49: 2The Pharmacology of THC,the Psycho
Page 50 and 51: The Pharmacology of THC 31into aque
Page 52 and 53: The Pharmacology of THC 33Marshall'
Page 54 and 55: The Pharmacology of THC 35Adams's c
Page 56 and 57: The Pharmacology of THC 37and nucle
Page 58 and 59: The Pharmacology of THC 39pany labo
Page 60 and 61: The Pharmacology of THC 41aspirin-l
Page 62 and 63: The Pharmacology of THC 43The prese
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The Pharmacology of THC 45the canna
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The Pharmacology of THC 47for many
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The Pharmacology of THC 49Figure 2.
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The Pharmacology of THC 51number of
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The Pharmacology ofTHC 55Table 2.1.
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The Pharmacology ofTHC 57Figure 2.9
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The Pharmacology ofTHCC59that might
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The Pharmacology ofTHC 61periphery.
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The Pharmacology of THC 63of PSM to
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The Pharmacology of THC 65in the re
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The Pharmacology of THC 67effect no
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The Pharmacology of THC 69counts. T
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The Pharmacology of THC 71may somet
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The Pharmacology of THC 73and barki
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3The Effects of Cannabis on theCent
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The Effects of Cannabis on the Cent
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The Effects ofCannabis on the Centr
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The Effects ofCannabis on the Centr
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118 THE SCIENCE OF MARIJUANAthat th
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Cannabis has been used as a medicin
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124 THE SCIENCE OF MARIJUANA1842).
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126 THE SCIENCE OF MARIJUANARiver.
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128 THE SCIENCE OF MARIJUANAVictori
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130 THE SCIENCE OF MARIJUANAThe pop
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132 THE SCIENCE OF MARIJUANAthat is
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734 THE SCIENCE OF MARIJUANAdocumen
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136 THE SCIENCE OF MARIJUANAcontrol
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138 THE SCIENCE OF MARIJUANAwho rep
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140 THE SCIENCE OF MARIJUANAeffects
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142 THE SCIENCE OF MARIJUANAeffecti
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144 THE SCIENCE OF MARIJUANAbeforeh
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146 THE SCIENCE OF MARIJUANAseen a
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148 THE SCIENCE OF MARIJUANAExperim
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150 THE SCIENCE OF MARIJUANAPainAs
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152 THE SCIENCE OF MARIJUANAcentury
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154 THE SCIENCE OF MARIJUANAsuffere
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156 THE SCIENCE OF MARIJUANAmyelin
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158 THE SCIENCE OF MARIJUANAment pe
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Figure 4.3. Double-blind, placebo c
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162 THE SCIENCE OF MARIJUANAparticu
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764 THE SCIENCE OF MARIJUANAthan 10
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166 THE SCIENCE OF MARIJUANAFigure
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168 THE SCIENCE OF MARIJUANAically
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170 THE SCIENCE OF MARIJUANACannabi
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772 THE SCIENCE OF MARIJUANAin volu
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174 THE SCIENCE OF MARIJUANAexposur
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The initial enthusiasm for cannabis
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180 THE SCIENCE OF MARIJUANAChan et
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182 THE SCIENCE OF MARIJUANAimpairm
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184 THE SCIENCE OF MARIJUANAproved
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186 THE SCIENCE OF MARIJUANAnormali
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188 THE SCIENCE OF MARIJUANAtween c
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190 THE SCIENCE OF MARIJUANAcal tra
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Table 5.1. Composition of Mainstrea
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194 THE SCIENCE OF MARIJUANATable 5
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196 THE SCIENCE OF MARIJUANAwhite b
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198 THE SCIENCE OF MARIJUANAfrom ma
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200 THE SCIENCE OF MARIJUANAof ciga
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202 THE SCIENCE OF MARIJUANAFigure
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204 THE SCIENCE OF MARIJUANAto deli
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206 THE SCIENCE OF MARIJUANApsychot
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208 THE SCIENCE OF MARIJUANASome of
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The use of cannabis as a recreation
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212 THE SCIENCE OF MARIJUANAfor 18-
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214 THE SCIENCE OF MARIJUANAin Brit
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216 THE SCIENCE OF MARIJUANAmonly s
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218 THE SCIENCE OF MARIJUANADistrib
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220 THE SCIENCE OF MARIJUANAin the
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222 THE SCIENCE OF MARIJUANAattitud
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224 THE SCIENCE OF MARIJUANASociety
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226 THE SCIENCE OF MARIJUANApositiv
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228 THE SCIENCE OF MARIJUANAridden
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230 THE SCIENCE OF MARIJUANApsychol
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232 THE SCIENCE OF MARIJUANArange o
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234 THE SCIENCE OF MARIJUANAnothing
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236 THE SCIENCE OF MARIJUANAIn Moro
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238 THE SCIENCE OF MARIJUANAin turn
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It is not the purpose of this book
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242 THE SCIENCE OF MARIJUANAto have
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244 THE SCIENCE OF MARIJUANAWard's
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246 THE SCIENCE OF MARIJUANAWe thin
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248 THE SCIENCE OF MARIJUANAIn Aust
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250 THE SCIENCE OF MARIJUANAnot hol
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252 THE SCIENCE OF MARIJUANAsession
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254 THE SCIENCE OF MARIJUANAto an o
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256 THE SCIENCE OF MARIJUANAThere c
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258 THE SCIENCE OF MARIJUANAas anta
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260 THE SCIENCE OF MARIJUANAopiate
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262 THE SCIENCE OF MARIJUANAExpert
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264 THE SCIENCE OF MARIJUANAments.
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266 THE SCIENCE OF MARIJUANApublic
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268 THE SCIENCE OF MARIJUANAever ra
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270 THE SCIENCE OF MARIJUANAAndreas
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272 THE SCIENCE OF MARIJUANAtwo can
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274 THE SCIENCE OF MARIJUANALiu, B-
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276 THE SCIENCE OF MARIJUANAcare us
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278 THE SCIENCE OF MARIJUANAWu, T.
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280 INDEXCannabisdebate, 240-68in E
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282 INDEXNabilone, 40, 40f, 139-40,
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