Acanthaceae - International Journal of Pharmaceutical and ...

P.Praveen SriKumar and P.Pardhasaradhi, Int J Pharm Biomed Res 2013, 4(3), 145-148 147Table1Effect of aerial part of Ruellia tuberose on pH, total acidity, free acidity, ulcer index and % inhibition of ulcer index in pylorus ligation induced ulceration inratsSl.No. Compound Dose pH Total acidiy(mEq/L)Free acidity(mEq/L)Ulcer index% inhibition ofulcer indexMean±SEM1 Control Water 2.81±0.03 102.2 ± 0.06 86.4 ± 0.96 3.70 -- 8.6 ± 0.202 Ethyl acetate extract 250mg/kg 3.85 ± 0.03 60 ± 0.24 56 ± 0.15 1.64 55.6 3.8 ± 0.973 Ethyl acetate extract 500mg/kg 4.50 ± 0.22* 56 ± 0.15* 46.96 ± 0.24* 0.46 87.56 2.2 ± 0.20*4 Rantidine 20mg/kg 5.35 ± 0.22* 30.4 ± 0.48* 12.50 ± 0.26* --- 100 --Values were expressed as (Mean ± SEM), n=6,*p

P.Praveen SriKumar and P.Pardhasaradhi, Int J Pharm Biomed Res 2013, 4(3), 145-148 148[5] Arambewela, L.S.R., Thambugala, R., Ratnasooriya, W.D., Journal ofTropical Medicinal Plants 2003, 4, 191-194.[6] Arirudran, B., Saraswathy, A., Journal of Pharmacy Research 2011, 4,4344-4347.[7] Mary Kensa, V., Neelamegam, R., Plant Archives 2012, 12, 69-74.[8] Alam, M.A., Subhan, N., Awal, M.A., Alam, M.S., Sarder, M., Nahar,L., et al., Pharmaceutical Biology 2009, 47, 209-214.[9] Rajan, M., Kishorkumar, V., SatheeshKumar, P., Journal of Chemicaland Pharmaceutical Research 2012, 4, 2860-2868.[10] Trease G.E., Evans, W.C., Trease and Evans' Pharmacognosy: A.Physician's Guide to Herbal Medicine, 13 th Edn., Bailliere Tindall,London 1989.[11] Harbone, J.B., Phytochemical Method, Chapman and Hall Ltd., London1973.[12] OECD Guidelines for Testing of Chemicals, Revised draft guidelines425:30, Acute oral toxicity- up-and-down procedures 2001.[13] Shay, H., Komarow, S. A., Fels, S.S., Mernanze, D., Gruenstein, M.,Siplet, H., Gastroenterol 1945, 5, 43-61.[14] Todd, S., in: Davidson & Henry (Eds.), Clinical Diagnosis byLaboratory Methods, XIV Edn., WB Sunders Co., Philadelphia 1969,pp.762-780.[15] Main, I.H., Whittle, B.J., Br J Pharmacol 1975, 53, 217–224.