5MAX - Penumbra, Inc.

5MAXDirect Aspiration Enables ChoicePrePost5MAX and Separator Images courtesy of Drs. Imran Chaudry, Aquilla Turk and Ray Turner, Medical University of South Carolina, Charleston, SC5MAX 0.062"1Aspiration

Rate of Embolization to New Territory (ENT) 29%7%0.3%Penumbra System ®Trevo ENTSolitaire 3 4 5,6

TMMAXTechnology Optimizes Aspiration+83%+200%5MAX+83%4MAX0540323MAX041Flow RateData on fi le. Flow rates of 3MAX, 4MAX and 5MAX using MAX Pump and MAX Aspiration Tubing vs. 032, 041 and 054 using current pump and PST1.TMNew MAXPump• Delivers close to pure vacuum*• Large 0.088" ID reinforced tubingfor efficient flow• Simplified setup• QuietUse of MAX Pump with Penumbra System® is indicated for 20 inHg of vacuum.*Pure vacuum is 29.75 inHg

TM5MAXTMDirect AspirationEnables Choice• Direct Aspiration TMis applied to the site of occlusion• 5MAX reduces risk of embolization to new territory (ENT)• Maintains access for adjunctive devices5MAX Separator5MAX 0.025" IDVelocity Penumbra – Stroke Market Leader5MAX PositionNeurovascularEmbolectomyDevices1 st Penumbra2 nd Covidien3 rd StrykerSource: Millenium Research Group, published Dec. 2012© 2013 Millennium Research Group, Inc. All rights reserved. Reproduction, distribution,transmission or publication is prohibited. Reprinted with permission.

TM5MAXTMDirect AspirationEnables Choice• Direct Aspiration TMis applied to the site of occlusion• 5MAX reduces risk of embolization to new territory (ENT)• Maintains access for adjunctive devices5MAX Separator5MAX 0.025" IDVelocity Penumbra – Stroke Market Leader5MAX PositionNeurovascularEmbolectomyDevices1 st Penumbra2 nd Covidien3 rd StrykerSource: Millenium Research Group, published Dec. 2012© 2013 Millennium Research Group, Inc. All rights reserved. Reproduction, distribution,transmission or publication is prohibited. Reprinted with permission.

Penumbra System ® MAX Ordering InformationCatalogNumberDescriptionProximalODDistalODProximalIDDistalIDLengthCompatiblePenumbra DevicesReperfusion Catheters (Working)3MAXC 3MAX Reperfusion Catheter 4.7 F (0.062 in) 3.8 F 0.043 in 0.035 in 153 cm 3MAX Separator TM4MAXC 4MAX Reperfusion Catheter 6.0 F (0.080 in) 4.3 F 0.064 in 0.041 in 139 cm 4MAX SeparatorPSC054 5MAX Reperfusion Catheter 6.0 F (0.080 in) 5.0 F 0.064 in 0.054 in 132 cm 5MAX SeparatorSeparators (Total)3MAXS 3MAX Separator n/a 0.030 in n/a n/a 190 cm 3MAX Reperfusion CatheterPSF041 4MAX Separator n/a 0.035 in n/a n/a 175 cm 4MAX Reperfusion CatheterPSF054 5MAX Separator n/a 0.045 in n/a n/a 175 cm 5MAX Reperfusion CatheterDelivery Microcatheter (Working)VEL160STR Velocity Microcatheter 2.95 F (0.038 in) 2.6 F (0.034 in) 0.025 in 0.025 in 160 cm 4MAX Reperfusion Catheter5MAX Reperfusion CatheterAspiration AccessoriesPMX110 MAX Pump MAX CanisterPAPS2 MAX Canister MAX PumpPST2 MAX Aspiration Tubing All Reperfusion CathetersNeuron MAX 6F 088 Lumen Long Sheath Ordering InformationCatalogNumberDescriptionTipShapeWorkingLengthDistal FlexibleZoneOuter Diameter*Proximal /DistalInnerDiameterWireCompatibility(Crosscut Valve, RHV and Dilator Included)PNML6F088804 6F 088 Neuron MAX Long Sheath, 80/4 Straight 80 cm 4 cm 8F / 8F .088" .035 / .038”PNML 6F088804M 6F 088 Neuron MAX Long Sheath, 80/4 MP 80 cm 4 cm 8F / 8F .088" .035 / .038”PNML6F088904 6F 088 Neuron MAX Long Sheath, 90/4 Straight 90 cm 4 cm 8F / 8F .088" .035 / .038”PNML6F088904M 6F 088 Neuron MAX Long Sheath, 90/4 MP 90 cm 4 cm 8F / 8F .088" .035 / .038"1. Data on fi le, Penumbra, Inc.2. Fiehler J, Söderman M, Turjman F, et al. Future trials of endovascular mechanical recanalisation therapy in acute ischemic stroke patients: a position paper endorsed by ESMINTand ESNR – Part II: methodology of future trials. EJMINT Original Article 2012; http://www.ejmint.org/original-article/1236000072. Published September 4, 2012.3. Baxter B. Review of Penumbra System ® Trials: Low rate of embolization of previously uninvolved territory of the brain using the Penumbra System in acute ischemic stroke treatment.Poster presented at: 9th Annual Meeting of the Society of NeuroInterventional Surgery; July 23-26, 2012; San Diego, CA, USA.4. Noguiera RG, Lutsep HL, Gupta R, et al.; for the TREVO 2 Trialists. Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke(TREVO2): a randomized trial. Lancet 2012;380:1231-1240.5. Mendes PV, Castaño C, Chapot R, Bonafé A, Andersson T, Gralla J. Solitaire TM FR Revascularization device: A retrospective study as fi rst line device for acute ischemic stroke. Presentedat: 11th Congress of the World Federation of Interventional and Therapeutic Neuroradiology; November 8-11, 2011; Cape Town, South Africa. (Subsequent publication of the study doesnot discuss the data that was presented.)6. Mendes PV, Castaño C, Chapot R, Bonafé A, Andersson T, Gralla J. Solitaire TM FR Revascularization device: A retrospective study as fi rst line device for acute ischemic stroke. Presentedat the 10th Society of NeuroInterventional Surgery Practicum; April 27-28, 2012; New York, NY, USA. (Subsequent publication of the study does not discuss the data that was presented.)www.penumbrainc.comPenumbra, Inc. USA1351 Harbor Bay PkwyAlameda, CA 94502USA1.888.BRAIN.061.888.272.4606T 1.510.748.3200F 1.510.748.3232order@penumbrainc.cominfo@penumbrainc.comPenumbra Europe GmbHAm Borsigturm 4413507 BerlinGermanyT +49 30 2005 676-0F +49 30 2005 676-10order@penumbrainc.deinfo@penumbrainc.dePenumbra Neuro Australia PTY LTDSuite 3, Level 5, 1 Oxford StreetDarlinghurst NSW 2010AustraliaT +61-1300 817 025F +61-1300 817 026order.anz@penumbrainc.comCopyright ©2013 Penumbra, Inc. All rights reserved. The Penumbra logo, Penumbra System, Penumbra System MAX, MAX Tracking Technology, Neuron and Velocity are registered trademarks or trademarks of Penumbra, Inc. in the USAand other countries. All other brands and product names are registered trademarks or trademarks of their respective owners. PC LI 6127 Rev. B 05/13 USA