GENESIS DRENCH with Selenium MSDS - Ancare

MATERIAL SAFETY DATA SHEETGenesis Drench with Selenium Oral Antiparasitic for SheepVersion: 3Issue Date: 31 May 2013Page 1 of 5SECTION 1IDENTIFICATION OF THE MATERIAL AND SUPPLIERSubstance:Ivermectin is a macrocyclic lactone.Product Use:Control of parasites in sheep and provides selenium supplementation.Supplier:Ancare Australia Pty LtdAddress: Building D, 12-24 Talavera Road, Macquarie Park, NSW 2113Phone (Toll-free): 1800 001 973All Hours Emergency Phone No.: Poisons Information Centre – 131126 anywhere in Australia.SECTION 2HAZARDS IDENTIFICATIONThis product is classified as: Hazardous according to the criteria of the National Occupational Health andSafety Commission’s Approved Criteria for Classifying Hazardous Substances [NOHSC:1008(2004)].Not classified as Dangerous Goods according to ADG Code 7.Risk Phrases:Precautionary(Safety) Phrases:Harmful if swallowed (R22);May cause harm to unborn child (R61);Harmful to aquatic organisms. (R52)SUSDP Classification: S5Potential Health EffectsSee section 11 for Chronic exposure studies.InhalationShort Term Exposure:Skin Contact:Short Term Exposure:Eye Contact:Short Term Exposure:Ingestion:Short Term Exposure:S20, S44, S61, S24/25. When using, do not eat or drink. If you feel unwell, contact adoctor or Poisons Information Centre immediately (show the label where possible).Avoid release to the environment. Refer to special instructions/Safety Data Sheets.Avoid contact with skin and eyes.Significant inhalation is unlikely. Unlikely to cause discomfort or irritation.The product is not classified as a skin irritant.The product is not classified as an eye irritant.The product is toxic via this route and is likely to cause headache and gastricdisturbance such as nausea and vomiting if ingested in significant quantities.Hospitalisation may need to be considered. See Section 11 for further information.CARCINOGEN STATUS:Not classified by ASCC (NOHSC), NTP or IARC.SECTION 3COMPOSITION/INFORMATION ON INGREDIENTSIngredients CAS No Conc % w/v Classification** Cut-off conc. Risk phrasesIvermectin 70288-86-7 0.8 Harmful Xn 0.5% 22 /61Sodium selenate 13410-01-0 0.05* - 1.0% -Non-hazardous ingredients to 100* Expressed as Selenium** at concentration present

Genesis Drench with Selenium Oral Antiparasitic for SheepVersion: 3Issue Date: 31 May 2013Page 13 of 5SECTION 4ADVICE:INHALATION:SKIN CONTACT:EYE CONTACT:INGESTION:FIRST AID MEASURESFor advice, contact a Poisons Information Centre (Phone 131 126 anywhere inAustralia), or call a doctor at once.Not an expected route of exposure. If mist is inhaled, remove from contaminatedarea. If adverse effects occur, contact a doctor and show this MSDS.If skin or hair contact occurs, remove contaminated clothing and flush skin and hairwith running water.If in eyes, hold eyelids apart and flush the eye continuously with running water.Continue flushing until advised to stop by the Poisons Information Centre or a doctor,or for at least 5 minutes.Urgent hospital treatment is likely to be needed. If swallowed in significant quantity,contact Poisons Information Centre. Medical observation needs to be carried out forup to 48 hours.Medical conditions aggravated by exposure - none known. Treatment issymptomatic.SECTION 5FIRE AND EXPLOSION HAZARDS:EXTINGUISHING MEDIA:FIRE FIGHTING:Special advice in case of fire:Hazardous products of combustion:FIRE FIGHTING MEASURESNot flammable nor combustible..Water spray/fog, dry chemical or CO2.Do not use water jet. Place emphasis on preventing contaminatedfire-fighting water from reaching drain or waterway.Emergency workers should wear full protective equipment andsupplied-air breathing apparatus. Toxic or irritant gases, vapours orparticulates may be generated in a fire. Spray water on containersto cool. Contain contaminated fire-fighting water.Oxides of carbon, hazardous particulates and unidentified pyrogenicvapours/substancesSECTION 6ACCIDENTAL RELEASE MEASURESIf spill is of significant quantity, move non-essential persons away. Do not allow product to enter drains,unpaved soil or sewer. Wear Personal Protective Equipment shown in Section 8 (at least skin, eye andrespiratory protection). Place leaking receptacles in an over-bin. Contain spill with a dyke of dry sand, earthor kitty litter. Sweep up absorbent and pack in fully labelled container for disposal. To cleanse thecontaminated area, wet down contaminated area with a small amount of water, again cover with absorbentand place used absorbent into the labelled container. Consult waste authority regarding disposal.OCCUPATIONAL RELEASE: As above.SECTION 7HANDLING AND STORAGEIf handling uncapped containers, (e.g., decanting), wear the personal protective equipment recommended inSection 8. Store away from incompatible liquids noted in Section 10, including oxidising agents. Store in abunded area if possible. Do not store with food or beverage. Store below 30°C in original container in a wellventilatedarea.Mechanical ventilation: Not required by regulations. May be beneficial when handling the liquid.Sources of ignition: Special controls not required.Harmful if swallowed. Avoid contact with the eyes, skin and clothing. If clothing becomes contaminated withproduct, remove clothing and launder. If product is on skin, wash with soap and water. If product is in eyes,wash it out immediately with water. After use and before eating, drinking or smoking, wash hands, arms andface thoroughly with soap and water

Genesis Drench with Selenium Oral Antiparasitic for SheepVersion: 3Issue Date: 31 May 2013Page 24 of 5SECTION 8EXPOSURE LIMITS:EXPOSURE CONTROLS/PERSONAL PROTECTIONASCC TWA = 0.1mg/cu.mASCC STEL= None established.The Time Weighted Average (TWA) is the concentration of the substance in the worker’s breathing zone, exposure towhich over 8-hour days, 5-day weeks over a working lifetime, should not cause any undue discomfort or healthimpairment to most workers. The Short Term Exposure Limit (STEL), means a 15 minute TWA exposure which shouldnot be exceeded and should not be repeated within 60 minutes or more than four times per day.Exposure Controls / Industrial hygiene:VENTILATION: Mechanical ventilation not required for normal use.RESPIRATOR: Not required for normal use.EYE PROTECTION: Wear eye protection while handling and applying. It is recommended that an eyewashor eye bath facilities be available where the liquid is being handled.SKIN PROTECTION: Wear skin protection while handling and applying..Equipment recommended for use when handling and cleaning-up a spill or leak:EYE PROTECTION: Use a face shield or eye protection complying with AS 1336 / 1337.SKIN PROTECTION: Wear impervious gloves such as neoprene rubber or PVC-coated cotton glovescomplying with AS/NZS 2161.2. Wear long-sleeved overalls and impervious footwear (AS2919, Industrial).SECTION 9PHYSICAL AND CHEMICAL PROPERTIESPhysical Description: Light yellow coloured liquid.Odour:No data.Boiling Point:Approximately 100°C at 100kPa.Freezing/Melting Point: Approximately 0°C.Volatiles:Water component.Vapour Pressure:2.37 kPa at 20°C (water vapour pressure).Vapour Density:No data.Specific Gravity: Approx 1.0Water Solubility:Completely soluble in water.pH:No data.Volatility:No data.Odour Threshold:No data.Evaporation Rate:No data.Coeff Oil/water Distribution: No dataViscosity: Ford # 4 cup; 9-13 sec at 20°CAutoignition temp:Not applicable - does not burn.SECTION 10Thermal decomposition:Hazardous decomposition:Hazardous decomposition products:Dangerous reactions:Reactivity:Conditions to avoid:/ Incompatible :Polymerisation:STABILITY & REACTIVITYNo decomposition occurs at normal storage temperatures.No significant decomposition expected at normal temperatures.Products of thermal or photodegradation have not been identified.None known.Stable.Contact with oxidising agents, strong acids or strong alkali.No hazardous polymerisation will occur.

SECTION 11Genesis Drench with Selenium Oral Antiparasitic for SheepVersion: 3Issue Date: 31 May 2013Page 5 of 5TOXICOLOGICAL INFORMATIONPossible routes of exposure Ivermectin ingredient (not the product)LD50 acute oral rat:50 mg/kgLD50 acute dermal rat: >660 mg/kgInhalation 4 hr rat:5.11 mg/LSkin irritation (rabbit): Skin irritantEye irritation (rabbit):Eye irritantSensitisation (guinea pig): Not a sensitising agentGenotoxicityNot genotoxicThe ingredient ivermectin is classified as a reproductive toxicant (category 2).LOCAL EFFECTS OF PRODUCT: May be irritant to eyes and skin.TARGET ORGANS:Eyes, Skin.HAZARDOUS INGREDIENTS: Ivermectin R-phrases: 61/64/28/24/50.MUTAGENICITY DATA:Negative in Ames test. Negative in mouse lymphoma mutationassay. Does not induce unscheduled DNA synthesis in humanfibroblast cell culture.Subacute to chronic toxicity:No data is available regarding sub-chronic or reproductive effects ofthe product.Additional toxicological information: Ivermectin is believed to bind to glutamate-gated chloride ionchannels; avoid drugs that also interact with other ligand-gatedchloride channels, including those which enhance GABA activity inpatients with potentially toxic ivermectin exposure. Reproductivetoxicant in rabbits and mice.Symptoms which may occur:Over-exposure to ivermectin may cause dilated pupils,incoordination, drowsiness, depressed motor activity, slowedbreathing, dilation of pupils, tremors, vomiting, anorexia, muscletremors, headache or dizziness.No other ingredient classified as a Hazardous Substance in the HSIS is present at hazardous concentrations.Sodium selenite is present at a concentration below the classification cut-off.SECTION 12Ivermectin:Bioaccumulation potential:TOXICITY TO FISH:TOXICITY TO DAPHNIA:TOXICITY TO ALGA:TOXICITY TO BACTERIA:READY BIODEGRADABILITY: Not availableEnvironmental Fate:ECOLOGICAL INFORMATIONVery toxic to certain aquatic species.LC50 - Daphnia magna, 48 hours = 0.025 ppb; NOEL D. magna = 0.01 ppb;LC50 - Rainbow trout, 96 hours = 3.0 ppb;LC50 - Bluegill sunfish, 96 hours = 4.8 ppb.Does not bioaccumulateLC50 = 0.3 ug/L - Rainbow Trout - very toxic to fish.EC50 48 hr = 0.025 ug/L (D. magna) - very toxic.Not availableNot availableIvermectin photodegrades rapidly in the environment and is metabolized inthe soil. Water solubility is limited and it binds to soil very tightly. It does notbioconcentrate in fish and is not taken up from soil to plants. Both aquaticand terrestrial studies confirm rapid degradation of ivermectin in theenvironment, and lack of accumulation and persistence.Do not contaminate dams, rivers or streams with product or empty containers.

Genesis Drench with Selenium Oral Antiparasitic for SheepVersion: 3Issue Date: 31 May 2013Page 6 of 5SECTION 13DISPOSAL CONSIDERATIONSDo not dispose of undiluted chemicals on-site. Triple or (preferably) pressure rinsethe empty container. If approved by the regulator (EPA), it may be acceptable tobury the container below 500 mm in a disposal pit specifically marked and set up forthis purpose clear of waterways, vegetation and roots. Empty containers should notbe burned.As the active ingredients are highly toxic to aquatic and some soil organisms, greatcare is needed to ensure that the product does not reach drains, or waterways.For the disposal of the clean-up materials from a significant spill, consult the wasteauthority.SECTION 14TRANSPORT INFORMATIONThis product is not classified as a Dangerous Good. No special transport conditions are necessary unlessrequired by other regulations.SECTION 15REGULATORY INFORMATIONAll of the significant ingredients are in the public AICS Database. Ingredients: Ivermectin and sodiumselenate are in the SUSDP.This product is registered with the Australian Pesticides and Veterinary Medicines Authority. APVMAApproval no.: 57812SECTION 16Acronyms:ADG CodeAICSCAS NumberHazchem NumberIARCASCCNOSNTPR-PhraseSUSDPUN NumberOTHER INFORMATIONAustralian Code for the Transport of Dangerous Goods by Road and RailAustralian Inventory of Chemical SubstancesChemical Abstracts Service Registry NumberEmergency action code of numbers and letters that provide information to emergencyservices especially firefightersInternational Agency for Research on CancerAustralian Safety and Compensation Commission (formerly NOHSC NationalOccupational Health and Safety Commission)Not otherwise specifiedNational Toxicology Program (USA)Risk PhraseStandard for the Uniform Scheduling of Drugs & PoisonsUnited Nations NumberGENESIS is a registered trademark.The product should be stored, handled and used in accordance with good industrial hygiene practices and in conformity with legalregulations. The information in this MSDS is based on the level of knowledge at the time of preparation and relates to the product in thestate in which it is supplied. The information describes the product from the safety point of view and is not intended to guarantee anyparticular properties and shall not establish a legally valid contractual relationship