Is it autoimmune hepatitis or DILI? - AASLD

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AUTOIMMUNE HEPATITIS100,000 – 200,000 persons in USAFemale>Male, all ages, occurs worldwide
Etiology– Unknown – usually no trigger identified– Viruses, drugs (minocycline) and herbalpreparations can trigger– Disease can persist despite withdrawal oftrigger– ? Molecular mimicry between foreign and selfantigens– Associated with other AI diseases
Page 1: Autoimmune Hepatitis orDrug Induced
Page 5 and 6: AUTOIMMUNE HEPATITISDiagnosis• In
Page 7: AUTOIMMUNE HEPATITISClinical featur
Page 10 and 11: NATURAL HISTORYCzaja A. Atlas Liver
Page 12: Drug Induced Liver Injury (DILI)Vs.
Page 15 and 16: DILI or AIH• Can be impossible to
Page 17 and 18: AIH vs. DILI• More severe in AIH-
Page 19 and 20: Autoimmune hepatitis(A) Interface h
Page 21 and 22: Model for cholestatic DILI orAIHB.
Page 23: Conclusion• There is overlap hist

Is it autoimmune hepatitis or DILI? - AASLD

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