Is it autoimmune hepatitis or DILI? - AASLD

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AUTOIMMUNE HEPATITISDisease Spectrum• Classical chronic hepatitis + cirrhosis• “Burned-out” cirrhosis• Acute hepatitis• Fulminant hepatitis• Overlap syndrome with PSC or PBC
AUTOIMMUNE HEPATITISDiagnosis• International AIH scoring system• ComplicatedHistologic hallmark is interface hepatitis, but notspecificHypergammaglobulinemia and autoantibodiesNo cholestatic featuresNo drug or viral cause, alcohol limit 25 g/dAlvarez F, et al. J Hepatol 1999;31:929-38; Hennes EM, et al. Hepatology 2008;48:169-76
Page 1 and 2: Autoimmune Hepatitis orDrug Induced
Page 3: Etiology- Unknown - usually no trig
Page 7: AUTOIMMUNE HEPATITISClinical featur
Page 10 and 11: NATURAL HISTORYCzaja A. Atlas Liver
Page 12: Drug Induced Liver Injury (DILI)Vs.
Page 15 and 16: DILI or AIH• Can be impossible to
Page 17 and 18: AIH vs. DILI• More severe in AIH-
Page 19 and 20: Autoimmune hepatitis(A) Interface h
Page 21 and 22: Model for cholestatic DILI orAIHB.
Page 23: Conclusion• There is overlap hist

Is it autoimmune hepatitis or DILI? - AASLD

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