Is it autoimmune hepatitis or DILI? - AASLD
Is it autoimmune hepatitis or DILI? - AASLD
Is it autoimmune hepatitis or DILI? - AASLD
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
AUTOIMMUNE HEPATITISGenetic Predispos<strong>it</strong>ions• HLA-DR3 and HLA-DR4 present in most CaucasianN<strong>or</strong>th American and N<strong>or</strong>thern European patientsw<strong>it</strong>h type 1 <strong>autoimmune</strong> hepat<strong>it</strong>is• HLA-DR3 (DRB1*0301) associated w<strong>it</strong>h early-ageonset, m<strong>or</strong>e treatment failure and frequent need f<strong>or</strong>liver transplantation• HLA-DR4 (DRB1*401) associated w<strong>it</strong>h a goodtreatment result, older patients, and frequentconcurrent immune diseases
Change language