General research objectives - DPZ

Department of Veterinary Medicine and Primate Husbandry 

DEPARTMENT OF VETERINARY MEDICINE AND 

PRIMATE HUSBANDRY 

Head of department: Prof. Dr. F.-J. Kaup 

General research objectives 

The Department of Veterinary Medicine and Primate Husbandry represents the 

central service and infrastructure sector of the German Primate Center (DPZ). 

Apart from infrastructural tasks, the department also carries out research, with a 

primary focus on the pathology of infections in the gastro-intestinal tract. Animals 

with experimental SIV-infection form the main subjects of research, where investigations 

centre on primary SIV-induced alterations as well as lesions and pathogenetic 

developments resulting from opportunistic infections. In this context, the intramural 

lymphatic tissues of the intestinal tract (GALT) and their reactions to different 

infectious agents are of particular interest. Apart from SIV infection, experimental 

helicobacter-infection in rhesus monkeys represents another animal model. 

The department also services a tumour register on spontaneous and experimentally 

induced neoplasms in non-human primates, and further investigates selected cases 

from pathomorphological diagnostics. 

Experimental Helicobacter pylori-infection in rhesus monkeys: RAPD-PCR typisation 

of re-isolated bacteria and comparison to strains BO417 and BO418 as used 

for inoculation (Primers used: AP1281 and AP1254). In three animals (Nos 7743, 

8156, 9050), bacteria of the strain B0417 were re-isolated as late as 18 months after 

experimental infection. Two weeks post infection (2wpi), animal no. 8156 still shows 

infection with both strains. 

Primate Report 60, July 2001 27


Structure of department 

The Department of Veterinary Medicine and Primate Husbandry comprises the 

working groups Pathology and Primate Husbandry. The working group Pathology 

is headed by a scientist and includes the fields of pathology, bacteriology and parasitology. 

The working group is also responsible for managing the central electron microscope 

laboratory. The Head of the working group is supported by six technicians 

(two of those part-time) and a necropsy assistant. During 2000, the group also 

included another scientific assistant, a postgraduate student supported by the Göttingen 

research programme ‚Perspectives of Primatology‘, a postgraduate student of 

the School of Veterinary Medicine in Hannover, and seven independently funded 

postgraduate students. 

The working group Primate Husbandry comprises the sectors feeding, animal 

husbandry, veterinary pharmacy and laboratory diagnostics. Two veterinary practitioners 

are tasked with managing all veterinary aspects of husbandry and care of the 

breeding colonies. They also provide veterinary care for the experimental animals 

owned by the Departments of Reproductive Biology and Neurobiology. One veterinary 

practitioner is currently studying for a special veterinary qualification in the 

field of experimental animal care. A colony manager is responsible for all organisatorial 

tasks including acquisition and sale of animals. Further support is provided 

by fifteen technicians, part-time assistants and trainees. Together with the Department 

of Virology and Immunology, the working group also includes an EU-financed 

scientist responsible for the organisation of an EU project on estimating the risks of 

transmissible spongiform encephalopathies. 

Scientists 

Dr. Uwe Hahmann 

Dr. Petra Hofmann 

Dr. Christoph Knogge (-30.09.00) 

Dr. Kerstin Mätz-Rensing 

Other staff 

Karin Hampe (Job creation scheme, 

01.07.00-) 

P. Kekemenis (Job creation scheme, 

01.07.00-) 

PhD students 

Anja Blankenburg (01.08.00-) 

Karin Bingger 

Savio Freire Bruno (-01.04.00) 

Konstanze Kahnt (-30.06.00) 

Tanja Koch 

Emanuela Kunz (-30.06.00) 

Andrea Quohs (01.09.00-) 

Kathrin Schmidt 

Hanspeter Steinmetz (-30.06.00) 

Veterinary Care 

Susanne Rensing 

Dr. Monika Ziegler (14.06.00) 

Colony management 

Uwe Schönmann 

Secretariat 

Kira Gee (-30.09.00; part-time) 

Antje Pflüger (-31.03.00, graduate 

programme secretariat, part-time) 

Ingrid Rossbach (part-time) 

Technicians: Pathology 

Helga Gilhaus 

Erna Hackenbroich 

Wolfgang Henkel 

Karin Kaiser-Jarry (part-time) 

Nadine Knöchelmann (01.08.00-) 

Elke Lischka 

Eva Nicksch (-31.03.00) 

Hafiza Zuri 

28 Primate Report 60, July 2001


Technicians: Primate Husbandry 

Henry Benseler 

Nadine Bertram (01.09.00-) 

Holger Bölling 

Martin Brüggemann 

Sarah Dittmann (-30.04.00) 

Ilona Dix 

Gerhard Fleckenstein 

Torsten Freckmann 

Jürgen Gans 

Heike Giller 

Eduard Herdt 

Annette Husung 

Silvia Kasper (20.12.00-) 

Melanie Koch 

Heinz-Josef Knöchelmann 

Silke Küster (part-time) 

Karl-Heinz Lambrecht 

Ramona Lenzner-Pollmann 

Susanne Passek 

Nadine Rudolph (29.06.00-) 

Helmut Rumpeltin 

Petra Stöfer 

Trainees: Animal Caretakers 

Sarah Blume (01.08.00-) 

Yvonne Dierich 

Nadine Rudolph (-28.06.00) 

Sarcocystis infection in an 

SIV-infected rhesus monkey: 

Electron microscope 

image showing a section of 

the cyst wall. Palisade-like 

protrusions (PV) form part 

of the cyst wall (CY) and 

connect the parasite to the 

host cell. Me = Metrocytes. 

Cyst wall thickness and 

length of protrusion indicate 

the presence of Sarcocystis 

kortei. 



Progress during the year 

Since the merger of the Working Groups 'Experimental Pathology' and 'Breeding 

and Animal Husbandry' with the 'Department of Pathology and Veterinary Care', 

the new Department of Veterinary Medicine and Primate Husbandry has become 

the main DPZ infrastructure department. Tasked by the Scientific Advisory Committee, 

its main objective is to guarantee and optimize all DPZ services. Infrastructural 

services include animal breeding, animal acquisition and sale, the provision 

of quarantine, all aspects of veterinary care including diagnostic services in pathology, 

bacteriology and parasitology, and management of the veterinary pharmacy. 

The tasks provided by the Animal Welfare Officer and Infectious Disease Officer, 

both of whom are required by law, also continue to be of central importance. Another 

service is the management of the central electron microscopy laboratory, which is 

used by internal and external groups. 

A case from diagnostic pathology: 

Severe alterations 

of the knee occurring during 

chronic purulent gonitis 

in a barbary ape (Macaca 

sylvanus). 

The promotion of the former Acting Head of department to the position of Professor 

of Experimental Animal Pathology at the School of Veterinary Sciences in 

Hannover, together with his promotion to Head of Department until 2005, ensures 

the continuation of the Department‘s service-oriented research and guarantees a 

further optimization of infrastructure. Apart from management of its internal research 

programme, its services also include the management of projects carried out 

for external partners. Currently joint projects include: 

• Co-operation with the School of Medicine, Hannover, on Xenotransplantation of 

transgenic pig kidneys to cynomolgus monkeys (Macaca fascicularis); 

• Co-operation with the Research Center, Jülich, in the testing of image processing 

procedures on the CNS of baboons (Papio hamadryas); 

• Co-operation with Aachen Hospital in research on the pathogenesis of nephropathy 

in marmosets (Callithrix jacchus) as a model for human kidney disease; 

• Co-operation with four European institutions as part of an EU-Programme on estimating 

the risks of transmissible spongiform encephalopathies. 



The research programme of the department reflects the particular needs of the 

service sector, with the pathology of infections representing a major focus. Most work 

is carried out jointly with the Department of Virology and Immunology and centres 

on two important infectious diseases in primates, both of which are relevant to veterinary 

and human medicine: 

• SIV-infection in rhesus monkeys (Macaca mulatta) 

• Helicobacter-infections in non-human primates 

SIV-Infection in rhesus monkeys 

Section of a plasma cell showing 

intracytoplasmic tubuloreticular 

structures (X) and so-called Russel 

Bodies (RB) in the dilated cisterns 

of the endoplasmic reticulum 

(er). Transmission electron 

microscope, Lamina propria of 

the rectum, SIV-infected rhesus 

monkey 12 weeks post-infection. 

Diss. Bruno (2000) 

The animal model of SIV-infection involves collaboration with the Department 

of Virology and Immunology at the DPZ, Homburg University, Würzburg University, 

Erlangen-Nürnberg University and the BNI in Hamburg. Our own research focuses 

on primary SIV-induced alterations and the pathogenic processes accompanying opportunistic 

infections, where the spread of the virus in the lymphatic tissues and the 

gut-associated mucosal immune system is of particular interest. Other investigations 

focus on the pathogenesis of SIV-associated lymphomas and primary SIVinduced 

CNS alterations. 



Immunohistological representation of myelobacterial antigen in the lymph node of a 

squirrel monkey (Saimiri sciureus). This probably represents atypical mycobacteria 

cross-reacting with a Mycobacterium bovis antibody. Apart from mononuclear cells, 

antigen is also present in a giant cell. Paraplast, ABC-method, Obj. 40x, Diss. 

Rensing (2000). 

In a restrospective study, 16 SIV-associated malignant lymphomas were investigated 

in rhesus monkeys. These had occurred 7 to 26 months after experimental infection 

in the advanced stages of immunodeficiency. They were situated multicentrally 

extranodally, with the gastrointestinal tract and the kidneys preferably affected. 

Lymphomas were also present in the CNS, in periocular tissue, in the nasal 

cavity and in the heart. Using the Kiel classification, they were classified as eleven 

centroblastic lymphomas, three immunoblastic lymphomas, one Burkitt lymphoma 

and an immunocytoma. Tumour cells were CD20+, and in some of the cases immunohistochemistry 

gave evidence of monoclonality. Although no SIV antigen was detected 

in the tumour cells, infection with lymphocryptovirus (RhLCV) was demonstrated 

in 94% of cases. RhCLV is also known as rhesus monkey EBV (RhEBV) or 

cercopithecine Herpesvirus 15. 

Tumour cells often expressed Bc12, c-Myc, P21 and P53. Bc16 was only detected 

in the Burkitt lymphoma. The expression of these proliferation-associated genetic 

products reflects the presence of genetic or epigenetic mechanisms that play a role in 

the pathogenesis and progression of SIV-associated lymphomas. A tentative correlation 

between these genetic products and the apoptosis indices was only established 

for Bc12-expression. 



Alterations of the CNS (SIVE) in SIV-infected rhesus monkeys only occurred in 

cases of so-called 'rapid progression' of disease. Alterations were classified into four 

categories: granulomatous inflammations with occurrence of giant cells, perivasculitis, 

meningitis and demyelinizations of the substantia alba. Alterations were accompanied 

by an increased rate of apoptosis, which was detected using the TUNELmethod. 

Although no opportunistic agents were present, SIV-antigen was present in 

the altered regions. 

Electron microscopical investigations of the SIV antigen load in the intestinal 

tract led to the discovery of tubuloreticular structures (TRS) in the rectum, which 

were systematically analysed during the course of disease using biopsies. TRS were 

shown to be present in all experimental animals from one week p.i, with macrophages, 

endothelial cells, plasma cells, lymphocytes, fibroblasts and neutrophilous 

granulocytes equally affected. The paracristalline structures were characterized by 

a tubuline diameter of 20 – 30 nm and formed large sheets of polymorphous structures 

in the cytoplasma of affected cells. In 37 % of animals, TRS were detected as 

early as three days p.i., but they were only present in a few cells and sparsely developed. 

Since such TRS were also detected in some control biopsies, the occurrence of 

TRS is of limited prognostic and diagnostic value during SIV infection. TRS are 

linked to the deposition of interferon. Despite their limited prognostic value, they do 

represent a notable morphological indicator of SIV infection, with the added advantage 

of occurring very early during the course of infection. 

Helicobacter- infections in primates 

Diagnostic pathology: 

Severe liver cysts in a cotton-top 

tamarin (Saguinus 

oedipus). 

The primate model of Helicobacter (H.) pylori-infection in rhesus monkeys (Macaca 

mulatta) has now been established. Co-operating with a working group at the 

University of Würzburg (Prof. Suerbaum), three rhesus monkeys were experimentally 

infected with different human pathogenic isolates. The following results were 



obtained: "Large gastrointestinal spirals" (LGIS) that were present in the monkey 

stomachs prior to infection could not be permanently eradicated by either of three 

therapeutic approaches applied. H.-pylori-isolates freshly obtained from human patients 

are better suited to infection than the multiple passaged laboratory strains, 

even when they contain the human pathogenic factors CagA+/VacA+. In two of the 

three animals, the experimental infection could be traced for a period of 18 months. 

Several methods however are required to confirm the infection in stomach biopsies, 

where 16S-rDNA sequence analysis is of particular importance. This technique allows 

the molecular biological identification of the bacteria isolated from the mucosa 

and their comparison to the bacterial strains used for experimental infection. 

In co-operation with the Institute of Veterinary Medicine at the University of 

Göttingen, the occurrence of Helicobacter spp. was investigated in domestic cats. 

Using microbiological and molecular biological methods, none of the 100 animals 

tested showed infection with H. pylori. 84 % showed infection with H. heilmanii, and 

20 % showed infection with H. felis. Except for one cat (H. felis only), all were infected 

with more than one species. Using light- and electron microscopy, a correlation was 

established between the intensity of colonization and the presence of chronic gastric 

lesions. 8 animals showed symptoms of inflammation without evidence of Helicobacter 

spp., and in 16 animals Helicobacter structures were present without inflammatory 

alterations. On the basis of these results, cats can be excluded as intermediate 

hosts in the transmission of H. pylori to humans. Infections with LGIS mostly 

produce no symptoms. 

Diagnostic pathology: Stomach ulcers can also occur in rhesus monkeys (Macaca 

mulatta). Subacute ulcerative gastritis. 


Other projects 


Apart from research on SIV and Helicobacter pylori-infections, several smaller 

projects were carried out on the pathology of primates. These included the detection 

of tuberculosis in squirrel monkeys and an analysis of alopecia in rhesus monkeys. 

Both studies are now completed. While researching the pathology of echinococcosis 

in lion-tailed macaques, further clinical cases occurred. Lion-tailed macaques appear 

to be particularly susceptible to this important zoonosis, so that work in this 

field has been intensified. Collaborating with the Working Group Immunogenetics, 

genetic markers are now being sought that might explain the particular susceptibility 

of these animals. Another freshly launched project is concerned with Wasting 

Marmoset Syndrome in the DPZ marmoset colony. 

Alveolar echinococcosis in liontailed 

macaques (Macaca silenus). 

The liver contains numerous 

cysts of the fox tapeworm 

Echinococcus multilocularis, 

(above). Light microscopy reveals 

protoscolical structures in the 

fertile metacestodes (below). 



In co-operation with the Department of Ethology and Ecology and the Institute of 

Zoology, Ecology and Conservation at the University of Hamburg, an investigation 

has begun of possible links between endoparasitic load and MHC variability in 

madagascan lemurs and rodents. Variability of MHC genes can serve as an indicator 

for the resistance to diseases or parasites, which in turn is linked to the long-term 

ability of populations to survive. MHC diversity can be reduced in fragmented habitats 

as a result of genetic drift and inbreeding, which leads to a lowering of allelic diversity 

and the fixation of disadvantageous alleles. The assessment of endoparasitic 

load and variability of functional MHC areas is carried out against this background. 

Projects and partners in cooperation 

Projects and Partners of the Department of 

Veterinary Medicine and Primate Husbandry 

Pathogenesis of intestinal alterations that accompany experimental 

SIV-infection in rhesus monkeys 

F.-J. KAUP, K. MÄTZ-RENSING, P. HOFMANN, S. F. BRUNO, 

M. ZEITZ, T. SCHNEIDER (Univ. Hospital, Homburg), P. RACZ, 

A. FLOTO (Bernhard-Nocht-Institute, Hamburg), N. STOLTE, C. STAHL- 

HENNIG (Dept. of Virology and Immunology, DPZ) 

Pathogenesis of primary and secondary alterations in different 

organs of SIV-infected rhesus monkeys 

F.-J. KAUP, K. MÄTZ-RENSING, P. HOFMANN, S. F. BRUNO, 

K. SCHMIDT, N. STOLTE, C. STAHL-HENNIG (Dept. of Virology 

and Immunology, DPZ) 

Oral mucosa as a port of entry for SIV and the specific role 

of dendritic cells 

C. STAHL-HENNIG, N. STOLTE (Dept. of Virology and Immunology, 

DPZ), K. MÄTZ-RENSING, R. STEINMAN (Rockefeller Univ., New York, 

USA) R. TENNER-RACZ, P. RACZ (Bernhard-Nocht-Institute, 

Hamburg) 

Development of an SIV/HIV vaccine 

H. PETRY, E. MEYER, N. STOLTE, C. STAHL-HENNIG, H. LAUTER- 

BACH, Y. ZHANG (Dept. of Virology and Immunology, DPZ), K. MÄTZ- 

RENSING, P. HOFMANN, F.-J. KAUP, W. LÜKE (Dept. of Virology and 

Immunology, DPZ) 

Experimental Helicobacter-Infection in rhesus monkeys (Macaca 

mulatta) 

K. MÄTZ-RENSING, E. KUNZ, D. LORENZEN, G. FELDMANN (Dept. 

of Virology and Immunology, DPZ), S. SUERBAUM (Inst. of Hygiene and 

Microbiology, Würzburg Univ.), F.-J. KAUP 

I,E L 

I L 

E,I L 

I L 

E,I L 





Microbiological and immunological characterization of 

helicobacter-infections in rhesus monkeys 

K. MÄTZ-RENSING, E. KUNZ, F.-J. KAUP, S. SUERBAUM (Inst. of 

Hygiene and Microbiology, Würzburg Univ.), B. KNAPP (Chiron-Behring 

Co., Marburg), H.J. MONSTEIN (Div. Clinical Microbiology, KMÖ, 

Linköpping, S), C. KRAFT, G. FELDMANN, D. LORENZEN (Dept. of 

Virology and Immunology, DPZ) 

E,I L 

Epidemiology of human Helicobacteriosis: The occurrence of 

Helicobacter sp. in cats 

U. BRANDENBURG (Inst. of Veterinary Medicine, Göttingen Univ.), 

K. MÄTZ-RENSING, F.-J. KAUP 

Rapid faecal test for diagnosing Helicobacter-infections in 

nonhuman primates 

E A 

K. MÄTZ-RENSING, E. KUNZ, S. LACKNER (Connex Co, Martinsried) 

Helicobacter-Infections in tupaias 

E A 

K. MÄTZ-RENSING, F.-J. KAUP, E. FUCHS (Dept. of Neurobiology, 

DPZ) 

I A 

The occurrence of spontaneous tumours in captive primates 

P. HOFMANN, K. MÄTZ-RENSING, F.-J. KAUP 

L 

Xenotransplantation of transgenic pig kidneys in cynomolgus 

monkeys 

M. Winkler (Dept. of Abdominal Surgery, School of Medicine, Hannover), 

K. MÄTZ-RENSING, P. HOFMANN, S. RENSING, F.-J. KAUP 

E L 

PET- and MRI studies in baboons with focus on the stress load 

during non-invasive animal experiments 

H. MÜHLENSIEPEN (Jülich Research Center), S. RENSING 

Experimental Herpesvirus saimiri-infection in marmosets 

(Callithrix jacchus) with subsequent virostatic therapy 

E L 

C. STAHL-HENNIG, N. STOLTE, D. LORENZEN, G. FELDMANN (Dept. 

of Virology and Immunology, DPZ), K. MÄTZ-RENSING, P. HOFMANN, 

H. FICKENSCHER (Inst. of Virology, Erlangen-Nürnberg Univ.) 

E,I A 

Preclinical assessment of viral genetic transfer systems in rhesus 

monkeys 

G. FELDMANN, N. STOLTE (Dept. of Virology and Immunology, DPZ), 

H. FICKENSCHER (Inst. of Virology, Erlangen-Nürnberg Univ.), 

K. MÄTZ-RENSING, U. SAUERMANN (Working Group Primate 

Genetics, DPZ) D. LORENZEN (Dept. of Virology and Immunology, DPZ) 

E,I A 





Retinal afferences in tupaias 

S. REUSS (Mainz Univ., S. RENSING, E. FUCHS (Dept. of Neurobiology, 


Diagnosis and therapy of transmissible spongiform encephalopathies 

(TSE) using evolutive phage antibodies that only bind 

to pathogenic prion proteins 

A. W. STUKE, O. AHMAD-OMAR (Dept. of Virology and Immunology, 

DPZ), F.-J. KAUP, P. RÖSCH (Dept. of Structure and Chemistry of 

Biopolymers, Bayreuth Univ.), T. SKLAVIADIS (Aristotelian Univ. 

Thessaloniki, GR), J. COLLINGE (Imperial College/St. Mary´s Hospital, 

London, GB) 

Risk potential analysis of bovine spongiform encephalopathies 

U. HAHMANN, F.-J. KAUP, J. LÖWER (Paul-Ehrlich-Institute, Langen), 

P. BIERKE (SIIDC Stockholm, S), D. DORMONT (CEA Fontenay-aux- 

Roses, F), M. POCCHIARI (ISS Rom, I), G. HUNSMANN (Dept. of Virology 


JCV-VLP as a vector in gene therapy 

C. GOLDMANN, O. AST, E. MEYER, Y. ZHANG (Dept. of Virology and 

Immunology, DPZ), F.-J. KAUP, K. MÄTZ-RENSING, J.-D. FAUTECK, 

W. RÖMER, H. SCHULZ, M. OETTEL (Jenapharm Ltd, Jena), K. LEMKE, 

J. METZE (Inst. of Bioprocess and Analytical Measurement Techniques, 

Heiligenstadt), H. PETRY, W. LÜKE (Dept. of Virology and Immunology, 


Development of an HIV-1 vaccine 

H. PETRY, E. MEYER, N. STOLTE, C. STAHL-HENNIG, Y. ZHANG 

(Dept. of Virology and Immunology, DPZ), K. MÄTZ-RENSING, F.-J. 

KAUP, G. HÖHN, S. FISCHER, R. MEYER-PITTROFF (Dept. of Energy 

and Environmental Technology, Technical Univ. Munich-Freising), 

W. LÜKE (Dept. of Virology and Immunology, DPZ) 

Cellular and humoral immune responses during progressive 

multifocal leucoencephalopathy (PML) 

F. WEBER (Dept. of Neurobiology, Univ. Hospital Göttingen), A. AGUZZI 

(Univ. Hospital Zürich, CH), C. SINDIC (Catholic Univ. Brüssel, B), 

T. WEBER (Div. of Neurology, St. Mary‘s Hospital, Hamburg), P. CINQUE 

(San Raffaele Hospital Mailand, I), F.-J. KAUP, W. LÜKE (Dept. of Virology 


The occurrence of Wasting Marmoset Syndrome in the marmoset 

colony (Callithrix jacchus) at the DPZ 

A. QUOHS, S. RENSING, F.-J. KAUP 

E,I A 

E,I L 

E,I L 

E,I L 

E,I L 

E,I L 

38 Primate Report 60, July 2001 

L



Establishing methods for diagnosing Herpes B-virus infections 

K.D. JENTSCH (Dept. of Virology and Immunology, DPZ), F.-J. Kaup, 

H. Schmitz (Bernhard-Nocht-Institute for Tropical Medicine, Hamburg), 

H. HUEMER (Inst. of Hygiene, Innsbruck, A) C. Coulibaly (Paul- 

Ehrlich Institute, Langen), P. LILJESTRÖM (Karolinska Institute Stockholm, 

S) 

Vaccination of juvenile macaques against Herpes B-virus infection 

K.D. JENTSCH (Dept. of Virology and Immunology, DPZ), F.-J. Kaup, 

H. SCHMITZ (Bernhard-Nocht-Institute of Tropical Medicine, Hamburg), 

P. LILJESTRÖM (Karolinska Institute, Stockholm, S), C. Coulibaly 

(Paul-Ehrlich Institute, Langen) 

Endoparasite load and MHC-variability of endemic Madagassian 

lemur and rodent species 

D. SCHWAB (Dept. of Ethology and Ecology, DPZ), K. MÄTZ-RENSING, 

S. Sommer (Inst. of Zoology, Ecology and Conservation, Hamburg Univ.) 

Echinococcosis in nonhuman primates kept outdoors 

A. BLANKENBURG, K. MÄTZ-RENSING, S. RENSING, 

K. JANITSCHKE (Robert Koch Institute, Berlin), U. SAUERMANN 

(Working Group Primate Genetics, DPZ), F.-J. KAUP 

Scientific contributions 

Doctoral theses 


E,I L 

E,I L 

E,I L 

E,I L 

BRANDENBURG, U.: The occurrence of Helicobacter spp. in domestic cats. School of 

Veterinary Medicine, Hannover (2000). 

BRUNO, S. F.: The occurrence of tubuloreticular structures in the rectal mucosa of 

SIV-infected rhesus monkeys. School of Veterinary Medicine, Hannover (2000). 

KAHNT, K. J.: SIV-associated lymphomas in rhesus monkeys (Macaca mulatta). 

School of Veterinary Medicine, Hannover (2000). 

KOCH, T.: Pathomorphological characterization of "spotting lethal rat". School of 

Veterinary Medicine, Hannover (2000). 

KUNZ, E.: Helicobacter pylori-infection in rhesus monkeys (Macaca mulatta) – 

Establishment of an animal model at the German Primate Center. School of Veterinary 

Medicine, Hannover (2000). 

RENSING, H.: Tuberculosis in squirrel monkeys: An evaluation of diagnostic tests 

in the DPZ squirrel monkey colony. School of Veterinary Medicine, Hannover (2000). 



SCHMIDT, K.: Neuropathological alterations in SIV-infected rhesus monkeys. 

School of Veterinary Medicine, Hannover (2000). 

STEINMETZ, H. W.: Alopecia in rhesus monkeys (Macaca mulatta): A dermatological 

investigation. School of Veterinary Medicine, Hannover (2000). 

Congress contributions 

National Cancer Institute Workshop "Comparative pathobiology of HIV- and SIVassociated 

lymphoma", New Orleans (USA), 29.-31.03.00, MÄTZ-RENSING, K., 

KAHNT, K., HOFMANN, P., KAUP, F.-J.: Malignant lymphomas in SIV-infected rhesus 

monkeys. 

1 st Joint Meeting Soc. Cutaneous Ultrastr. Res. und AG Analyt. Morphologie Exp. 

Dermatoonkologie der ADF, Bochum, 04.-06.05.00, HOFMANN, P., GILHAUS, H., 

STOLTE, N., KAUP, F.-J.: Incidence of Malassezia sp. in immunodeficient rhesus 

macaques (Macaca mulatta). 

Annual Meeting of the European Association of Zoo and Wild Animal Veterinarians, 

Paris, 31.05.-03.06.00, OSMANN, C., KAUP, F.-J., HOFMANN, P., GÜNTHER, S., 

ASPER, M., SCHMITZ, H., ENDERS, G. METZGER, C., REINACHER, M.: Infection 

with "lymphocytic choriomeningitis virus" of new world primates at Dortmund 

Zoo: Epizootiological and diagnostical aspects. 

43 rd Annual Meeting of the Expert Group Pathology of the German Veterinary Society, 

Kiel, 06.-08.06.00, 

KAHNT, K., MÄTZ-RENSING, K., HOFMANN, P., KAUP, F.-J.: Clinical, pathomorphological 

and immunohistochemical characteristics of SIV-associated lymphomas 

in rhesus monkeys. 

HOFMANN, P., MÄTZ-RENSING, K., RENSING, S., KAUP, F.-J.: Lethal Herpesvirus 

infection in a group of golden-headed lion tamarins (Leontideus chrysomelas). 

MÄTZ-RENSING, K., RENSING, S., HOFMANN, P., BRACK, M., KAUP, F.-J.: 

Echinococcosis in a group of lion-tailed macaques (Macaca silenus). 

4 th International Workshop on Pathogenesis and Host Response in Helicobacter Infections, 

Helsingor (DK), 06.-09.07.00, MÄTZ-RENSING, K., KUNZ, E., LOREN- 

ZEN, D., KRAFT, C., SUERBAUM, S. KAUP, F.-J.: Experimental Helicobacter pylori 

infection in rhesus macaques (Macaca mulatta). First experience with a close to human 

animal model at the German Primate Centre. 

38 th Scientific Meeting of the GV-SOLAS, Essen, 11.-14.09.00, SCHÖNMANN, U.: 

Primates in experimental animal husbandry: From individual cages to keeping in 

groups. 

4th Meeting of the Expert Group "Gastrointestinal Infection" of the DGHM, Würzburg, 

29.09.-01.10.00, MÄTZ-RENSING, K., KUNZ, E., LORENZEN, D., KRAFT, C., 


SUERBAUM, S., KAUP F.-J.: Experimental Helicobacter pylori infection using the 

rhesus monkey animal model. 

18 th Meeting of the European Society of Veterinary Pathology, Amsterdam, NL, 

19.-22.09.00, 

KAUP, F.-J., HOFMANN, P., MÄTZ-RENSING, K., ZIEGLER, M., RENSING, S.: 

Nonhuman primates in biomedical research: diseases and pathology. 

HOFMANN, P., MÄTZ-RENSING, K., STOLTE, N., KAUP, F.-J.: Sarcocystis infection 

in an immunodeficient rhesus macaque (Macaca mulatta). 

HOFMANN, P., OSMANN, C., GÜNTHER, S., ASPER, M., SCHMITZ, H., KAUP, 

F.-J.: Callithrichid hepatitis in a pygmy marmoset. 

18 th Annual Symposium on Non-human Primate Models for AIDS, Madison, USA, 

03.-08.10.00, SAUERMANN, U., STAHL-HENNIG, C., MÜHL, T., STOLTE, N., 

KAUP, F.-J., ÜBERLA, K., HUNSMANN, G., SOPPER, S., SPRING, M.: AIDSrelated 

disease in macaques infected with attenuated SIV is mediated by host factors. 

2 nd Göttingen Symposium „Primates in Biomedical Research – Diseases and Pathology“, 

Göttingen, 08.-09.11.00 

BINGGER, K., MÄTZ-RENSING, K., RENSING, S., KAUP, F.-J.: Cystic bile duct 

adenoma in a cotton top tamarin (Saguinus oedipus): A case report. 

HOFMANN, P., ROLLE, S., RENSING, S., KAUP, F.-J.: Fatal herpesvirus infection 

in a group of golden-headed lion tamarins (Leontideus chrysomelas). 

MÄTZ-RENSING, K., RENSING, S., STAHL-HENNIG, C., KAUP, F.-J.: Critical 

evaluation of different diagnostic methods for tuberculosis in squirrel monkeys. 

RENSING, S., BRACK, M.: Erysipelothrix insidiosa in a colony of common marmosets. 

Seminar lectures 


Scientific Colloquium, Special Qualification Course, School of Veterinary Sciences, 

Hannover, 18.04.00, KAHNT, C.: Clinical, pathomorphological and immunohistochemical 

characteristics of SIV-associated lymphomas in rhesus monkeys. 

School of Veterinary Sciences Expo-Activity Day "Hunters, Farmers and Vets", 

Ruthe, 28.10.00, KAUP, F.-J.: Wild animal diseases – their significance for ecosystems 

and humans. 

Dies academicus of the Cath. Student Society Saxo-Silesia, Hannover, 28.10.00, 

KAUP, F.-J.: Primates in biomedical research: Necessity or cruelty? 

Lower Saxony Chamber of Veterinarians, special event on "Fields of Veterinary 

Practice", Hannover, 03.11.00, KAUP, F.-J.: Vets in teaching, science and research. 

Meeting of the AIDS Research Association Würzburg/Göttingen, Göttingen, 

27.11.00, KAUP, F.-J., BRUNO, S.: Tubuloreticular structures in the rectal mucosa: 

Epiphenomenon or prognostic tool? 



Open Afternoon, School of Veterinary Sciences, Hannover, 13.12.00, 

KAUP, F.-J.: The German Primate Centre, Göttingen: Primate-related research. 

KAUP, F.-J.: SIV-Infections in primates – animal models for AIDS research. 

School of Veterinary Medicine, Hannover, as part of application procedures for a 

C4-professorship in Veterinary Pathology, 18.12.00, KAUP, F.-J.: Gastrointestinal 

endoscopy – opportunities and limits in pathomorphological diagnosis and research. 

Other scientific activities 

F.-J. Kaup 

• DPZ Animal Welfare Officer and Animal Welfare Adviser for the Society of 

Primatology. 

• DPZ Infectious Disease Officer. 

• Member of the Assembly of the Lower Saxonian chamber of Veterinarians, 13 th 

elective period: Steering Group Member and Animal Welfare Committee Member. 

• Elected member of the Committee on Experimental Animal Science, National 

Chamber of Veterinarians. 

• Managing Board, European Primate Resources Network (EUPREN). 

• Editorial Board, Journal of Veterinary Medicine B, Referee for J. Med. Primatol. 

• Expert advice to various organisations and authorities to facilitate the co-operation 

between authorities. 

• Participation in public debates on animal experimentation: Munich, 25.06.00, 

Würzburg, 12.07.00; Radio, television or telephone interviews with NDR II, 

Hessischer Rundfunk, Deutschlandfunk, and ZDF on the topics of animal experiments 

and infectious disease research. 

S. Rensing 

• German Representative of the European Marmoset Research Group (EMRG) 

U. Schönmann 

• Representative of EFAT (European Association of Animal Technology) in the European 

Primate Group (PEG) 

A. Husung 

• Steering Group Member, Animal Caretaker Group, Society of Experimental Animal 

Sciences (IGTP-GV SOLAS)

General research objectives - DPZ

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