S aureus

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EnzymesCatalase all staph produce catalaseCoagulase S aureus produces coagulase, an enzyme-likeprotein that clots oxalated or citrated plasma. Coagulasemay deposit fibrin on the surface of staphylococci, perhapsaltering their ingestion by phagocytic cells .there are 2serological distinct types of coagulase free&clumpingfactor(acell bounding coagulase)Staphylokinase resulting in fibrenolysisLipaseHyalorodinase(spreading factor)B –lactemaseProteinases
PathogenesisStaphylococci, particularly S epidermidis, are members of the normal flora of the humanskin and respiratory and gastrointestinal tracts.Nasal carriage of S aureus occurs in 20–50% of humans. Staphylococci are also foundregularly on clothing, bed linens, and other fomites in human environmentSites of carrying staph. Are nose, skin fold,axilla,vagina&perinumThe pathogenic capacity of a given strain of S aureus is the combined effect of extracellularfactors and toxins together with the invasive properties of the strain.At one end of the disease spectrum is staphylococcal food poisoning, attributable solely tothe ingestion of preformed enterotoxin; at the other end are staphylococcal bacteremiaand disseminated abscesses in all organs.Pathogenic, invasive S aureus produces coagulase and tends to produce a yellow pigmentand to be hemolytic. Nonpathogenic, noninvasive staphylococci such as S epidermidis arecoagulase-negative and tend to be nonhemolytic. Such organisms rarely producesuppuration but may infect orthopedic or cardiovascular prostheses or cause disease inimmunosuppressed persons.S saprophyticus is typically nonpigmented, novobiocin-resistant, and nonhemolytic; itcauses urinary tract infections in young women
Page 1 and 2: Presented byDr zena makkie abd-alka
Page 3 and 4: Staphylococci has at least 35spps C
Page 5: Morphology & Identification• Typi
Page 8 and 9: GROUTH CHARECTARESTICS• The staph
Page 10 and 11: • Resistance to nafcillin , methi
Page 12 and 13: ANTIGENIC STRUCTURE OF STAPHYLOCOCC
Page 14 and 15: Toxins:•Pore-forming toxins - cre
Page 16 and 17: •Toxic Shock Syndrome Toxin• Mo
Page 20 and 21: Diseases cauced by staph.aureus1.Su
Page 22 and 23: • Toxin mediated infection1 Food
Page 24 and 25: Factors that predispose individual
Page 26 and 27: Diagnostic Laboratory Tests• Spec
Page 28 and 29: • Susceptibility Testing• Broth
Page 30 and 31: Treatment1 Tetracyclines are used f
Page 32: Thank you

S aureus

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