S aureus

Factors that predispose individual to seriousstaph.aureus infection1. Defect in opsonization by antibody2. Complement component deficiency like C3&C53. Defect in leukocyte chemotact factors either congenital like downsyndrome or acquired like D.M,R.A4. Defect in intracellular killing of bacteria following phagocytosis dueto inability to activate membrane bounding system result in absenceof peroxides &superoxidase killing enz from phacocytic vacuoleslike in chronic granulomotus diseases & in lymphoblastic lymphoma5. Skin injury like in eczima,burn &trauma6. Presence of foreign body7. Viral or bacterial infections as a complication8. Chronic underlying disease like malignancy, heart disease,alcohlicperson9. Prophylactic or therapeutic antimicrobial administration