H. pylori

H. Pylori associated specific diseasesPeptic ulcer diseases ulcers are “premodern”diseases• Gastric ulcer disease• Arose in the 19 th century in the USA & Europe• Peaked in the early 20 th century• Duodenal ulcers• Arose and peaked 10-30 years later• Reasons for the emergence of peptic ulcer disease• Cigarette smoking?• Increased H.pylori virulence?• Changes in immunity?:impaired gastric mucosal Treg response