H. pylori
H. pylori
H. pylori
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H. <strong>pylori</strong> adaptation to human colonization• Colonizes the stomach in childhood & persiststhroughout• Its spiral shape and flagella allow it to corkscrew throughthe gastric mucosal gel• Numerous adhesions enable selective adherence to thegastric epithelium• H. <strong>pylori</strong> has multiple mechanisms for protection againstgastric acid• 15% of its protein content comprises preformed cytoplasmicurease• It hydrolyses urea & releases ammonia• The ammonia neutralizes the periplasm and maintain thecytoplasmic membrane potential
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