043-056-Vlado Trajkovski-medicinski tretman - Journal of Special ...

MEDICINSKI TRETMANinteres za sekretinot kako mo`na terapijaza autizmot. Vo ovaa studija se uka`uva dekasekretinot mo`e da ja podobri sostojbataso crevnata li gavica, odnosno da ja normalizira,so {to se onevozmo`uva golemiteproteini, ili toksini da pominat od crevatavo krvta, so {to se prevenira sindromotna propu{tlivi creva (9). Koga se vnesuvavo terapevtski dozi, sekretinot se dava intravenski.Obi~no se dava vo pomali dozivo vremetraewe od {est nedeli, a vo golemadoza se dava edine~no. Dodeka vo nekoistudii nema izve{tai za nesakani efekti,nekoi drugi uka`uvaat deka e mo`no javuvawena osip po ko`ata, generaliziranocrvenilo na glavata, vratot i gradite vedna{po infuzijata, treska, tahikardija, po -vra}awe i zgolemena razdrazlivost. Ednood najnovite istra`uvawa gi otfrla nao -dite na onie studii kade {to sekretinot nepoka`al nikakov korisen efekt, ili imalnesakani dejstva. Ovaa dvojno-slepa, placebo-kontroliranai vkrstena studija poka-`uva deka sekretinot gi podobruva simpto -mite kaj decata so autizam {to imaathroni~na dijarea mnogu pove}e otkolku kajonie deca {to go nemaat ovoj problem. JanetKern i kolegite prou~uvale 19 deca soautizam davaj}i mu na sekoe dete ednainfuzija na sekretin (2CUs/kg) i edna infuzijana placebo solen rastvor. Istra`uva-~ite izvestile deka kaj 5 mom~iwa so hro -ni~na dijarea do{lo do namaluvawe na iri -tabilnosta, voznemirenosta, pla~eweto, hi -peraktivnosta, koga tie bile tretirani sosekretin, a nemale odgovor na placebo,dodeka drugite lica nemale odgovor ni nasekretin, ni na placebo. Kako dopolnuvawena ova, decata so autizam i hroni~na dijareapoka`ale podobruvawe vo re~nikot i namaluvawena stereotipnoto odnesuvawe.Pritoa bilo zabele`ano edno vlo{uvawekaj edno dete bez gastrointestinalni simptomi,kaj kogo do{lo do eskalirawe nabihejvioralnite problemi. Na krajot, tiezaklu~uvaat deka mo`ebi ima subtip nadeca so autizam ili pervazivno razvojnonaru{uvawe i hroni~na dijarea koi imaatpolza od sekretinot (10).This study shows that secretin can improve thecondition of intestinal mucus, i.e. normalize it disablingthe big proteins or toxins to pass from intestinesinto the blood, which prevents the syndromeof porous intestines (9). When inserted intherapeutic doses, the secretin is applied intravenously.It is usually applied in smaller doses induration of six weeks, or once if it is a bigger dose.Some studies show no side effects while othersreport possible occurrence of skin rash, generalizedblush on head, neck and chest immediatelyafter the infusion, as well as fever, tachycardia,vomiting and increased irritability. One of the latestresearches rejects the findings of the studieswhere secretin did not show any useful effect norhad unwanted activities. This double “blind”, placebocontrolled and cross-examined study showsthat secretin improves symptoms in children withautism and chronic diarrhea much better than inthose children without this problem. Janet Kernand colleagues studied 19 children with autism,giving each child an infusion with secretin(2CUs/kg) and one infusion of placebo salty solution.The researchers reported that 5 boys withchronic diarrhea reduced the irritability, anxiety,crying, hyperactivity when treated with secretin,and did not respond to placebo, while others didneither respond to secretin nor placebo. Additionallyto this, children with autism and chronic diarrheashowed improvement in vocabulary and reductionof stereotype behavior. The aggravationwas noticed in one child without gastrointestinalsymptoms who showed escalation of behavioralproblems. At the end, they concluded that therewas a subtype of children with autism or pervasivedevelopmental impairment and chronic diarrhea,who benefited the secretin (10).DEFEKTOLO[KA TEORIJA I PRAKTIKA 2004; 3-4: 43-5647