043-056-Vlado Trajkovski-medicinski tretman - Journal of Special ...

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$120 Liljana KATI] Jagoda \OR\EVI] RAN TRETMAN NA EDEN ...$

MEDICAL TREATMENTIstraùvawata za upotrebata na vitaminotB6 po~nale vo 60-tite godini od minatiotvek. Vo 1966 godina dvajca britanski nevrolozi- A.F. Heeley i G.E. Roberts – soop{tiledeka kaj 11 od 19 deca so autizam na{leabnormalni metaboliti vo urinata priupotrebata na triptofanski test. Davaj}iim po 30 mg tableta vitamin-B6 do{lo donormalizirawe na nivnata urina. Vo taastudija ne bile napraveni bihejvioralni ispituvawa.Germanskiot istraùva~ V.E.Bonisch vo 1968 godina izvestil deka kaj 12od 16 deca so autizam imalo zna~itelnopodobruvawe vo povedenieto koga im bilodadeno visoki dozi vitamin-B6 od 100 mg do600 mg dnevno. Trojca od negovite pacientiprvpat prozborele po davaweto na vitami -not-B6 vo ovoj otvoren klini~ki obid.Po izdavaweto na knigata "Infantilen autizam#od d-r Bernard Rimland vo 1964 godina,toj po~nal da prima stotici pisma od ro -ditelite koi se obidele so megavitaminskaterapija kaj nivnite deca so autizam. Vopra{alnikot, {to toj im go pratil na oko -lu 1000 roditeli, otkril deka 57 eksperi -mentirale so visoki dozi na vitamini.Mnozina od niv videle pozitivni rezultatikaj nivnite deca. Kako rezultat na toa, Rimlandpo~nal golema studija so preku 200 decaso autizam na koi im dal megadozi na vitamin-B6, nijacinamid, pantotenska kiselinai vitamin-C. Vitaminite bile smes teni voedna multipna tableta, specijalno dizajniranaza ovaa studija. Na krajot od studijata,po ~etiri meseci, bilo jasno deka vitaminotB6 bil najva`niot od site 4 ispituvanivitamini i deka vo nekoi slu~i dovel doizvonredno podobruvawe. Vitaminot-B6 po -kaàl zna~itelno podobruvawe kaj 30% do40% od decata. Samo nekolku od decatapokaàle minorni nesakani efekti (razdrazlivosti ~uvstvitelnost na zvukovi), notie is~eznale koga bil dodaden magnezium.Magneziumot ne samo {to gi eliminira nesakaniteefekti, tuku toj ~esto go podobruvagovorot i povedenieto. Dve godini po -docna toj i drugi dvajca istraùva~i iniciralevtora ekperimentna studija za mega vitaminskataterapija, koncentriraj}i se navitamin -B6 i magnezium.50The research on the use of vitamin B6 started inthe 60s of the last century. In 1966, two Britishneurologists – A.F. Heeley and G.E.Robers – reportedthat 11 of 19 children with autism foundabnormal metabolites in the urine using triptophantest. Applying each patient 30 mg tablet of vitaminB6 they succeeded in normalizing the urine. Thisstudy did not make any behavioral investigations.The German researcher V.E.Bonisch in 1968 reportedthat in 12 of 16 children with autismshowed significant behavioral improvement whenthey were applied high doses of vitamin B6 from100 mg to 600 mg per day. Three of his patientscould talk for the first time after applying vitaminB6 in this open clinical trial.After the publication of the book “Infantile autism”,Dr. Bernard Rimland in 1964 started receivinghundreds of letters by parents who hadtried megavitamin therapy on their children withautism. In the questionnaire he had sent to about1000 parents, he found out that 57 had experimentedwith high doses of vitamins. Most of themsaw positive resultants with their children. As aresult of this, Dr. Rimland started a large studywith over 200 children with autism who weregiven mega doses of vitamin B6, niacynamid,pantoten acid and vitamin C. The vitamins wereput in a multi type tablet, specially designed forthis study. At the end of the study, after fourmonths, it was obvious that the vitamin B6 was themost important one of the four examined vitaminsand that in some cases it brought excellent im -provements. The vitamin B showed considerableimprovement with 30% to 40% of the children.Only a few children showed minor unwanted effects(irritable and sensitive to sounds) which disappearedwhen magnes ium was added. Magnesium,not only eliminates unwanted effects, but itfrequently improves speech and behavior.Two years later, he and two other researchers initiateda second experimental study for megavitamintherapy, concentrating on vitamin B6 and magnesium.JOURNAL OF SPECIAL EDUCATION AND REHABILITATION 2004; 3-4: 43-56
MEDICINSKI TRETMANToj bil dvojno -slep placebo-kontroliraneksperiment kaj 16 deca so autizam i povtornoimalo statisti~ki zna~ajni rezul -tati. Dozite se dvièle me|u 300 mg i 500 mgdnevno.Vo dvete studii decata pokaàle {irokrang na izvonredni rezultati so vitamin -B6. Tie imale podobar kontakt so o~ite, po -kaùvale pogolem interes kon svetot okoluniv, pomalku bile besni, govorot bil po -dobar i, op{to zemeno stanale ponormalni.Francuskite istraùva~i, predvodeni odprof. Gilbert LeLord, napravile dopolnitelnoistraùvawe so vitamin -B6 i magnezium.Nivniot eksperiment go sprovele vrz 44hospitalizirani deca so autizam. Ottoga{imaat publicirano pove}e studii, kade {toja ispituvaat upotrebata na vitamin-B6 somagnezium ili bez nego kaj deca i adulti soautizam. Vo nivnite studii davan e 1 gramdnevno vitamin -B6 i polovina gram magnezium.LeLord i sor. neodamna gi rezimiralerezultatite od 91 pacient, kade {to zabeleàle:kaj 14% markantno podobruvawe,kaj 33% podobruvawe, 42% bile bez podo -bruvawe i kaj 11% vlo{uvawe na klini~ -kata slika. Vo site nivni studii ne bilezabeleàni nesakani dejstva.Drugi dve studii od istraùva~kite grupivo SAD, predvodeni od Thomas Gualtieri isor. na Univerzitetot vo Severna Karolinai George Ellman i sor. od So noma, dràvnatabolnica vo Kalifornija, imale pozitivnirezultati kaj pacientite so autizam (12).Vitaminot C e vaèn antioksidant i moèda bide od golema polza kaj decata so au tizam.Toj e vitamin rastvorliv vo voda i zatoamnogu retko moè da se zabeleìvistinska toksi~nost, osven {to moè da seformiraat kristali na askorbinskata kiselinavo urinata, koga toj se koristi vo ekstremnovisoki dozi. Vitaminot-C treba dapo~ne da se dava vo doza od 5-10 mg/kg/dnevnoso postepeno poka~uvawe na dozata. Avto -rite postavile hipoteza deka dejstvoto sedolì na pretpostavenite dopaminergi~kiefekti na vitaminot-C. Kako i da e, rezul -tatite od ovaa studija u{te ne se povtoreni(13).DEFEKTOLO[KA TEORIJA I PRAKTIKA 2004; 3-4: 43-56That was a double “blind”, placebo-controlled experimentwith 16 children with autism and againthere were statistically significant results. Thedoses ranged from 300 mg to 500 mg per day.In both studies, the children showed wide range ofexcellent results with vitamin B6. They had bettereye contact, showed bigger interest for the worldaround them, were less furious, their speech wasimproved, they became more normal in general.The French researchers led by Professor GilbertLeLord additionally examined vitamin B6 andmagnesium. Their experiment was carried out with44 hospitalized children with autism. Since then,they have published a large number of studies, examiningthe use of vitamin B6 with magnesium orwithout it, both with children and adults. In theirstudies, a daily dose of 1 g. vitamin B6 and half agram magnesium was applied. Lelord and associateshave summarized their results recently with 91patients and stated 14% with noticeable improvement,33% with improvement, 42% without im -provement and 11% with worse clinical picture. Inall their studies, unwanted actions have not beennoticed.Other two studies of the research groups fromUSA, led by Thomas Gualtieri and associates atthe University of North Caroline and George Ellmanwith associates from Sonoma, the state hospitalin California, has pos itive results in patientswith autism (12).Vitamin C is an important antioxidant and couldbe of great benefit for children with autism. Thevitamin is soluble in water and therefore real toxicityis rarely noticeable, except formation ofcrystals in ascorbine acid in the urine when used inextremely high doses. Vitamin C has to be appliedwith starting daily dose of 5/10 mg/kg and withgradual increase of the dose. The use of vitamin Chas been examined in a small double “blind”, placebo-controlledcross-examined study, where aslight alleviation of the symptoms has been foundin schoolchildren with autism. The authors haveput forward hypothesis that the action is due toassumed dopaminergic effects of vitamin C. Theresults of this study have not been repeated again(13).51
Page 1 and 2: MEDICINSKI TRETMANmedicinski tretma
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Page 5 and 6: MEDICINSKI TRETMANinteres za sekret
Page 7: MEDICINSKI TRETMANDesertite {to sod
Page 11 and 12: MEDICINSKI TRETMANPostepeno treba d
Page 13 and 14: MEDICINSKI TRETMAN• Izvori na pro

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