Annual 2006 - Hauptman Woodward Institute - University at Buffalo
Annual 2006 - Hauptman Woodward Institute - University at Buffalo
Annual 2006 - Hauptman Woodward Institute - University at Buffalo
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The <strong>Hauptman</strong>-<strong>Woodward</strong> Medical Research <strong>Institute</strong> (HWI) is an independent, not-for-profit,<br />
biomedical research facility loc<strong>at</strong>ed in the heart of downtown on the <strong>Buffalo</strong> Niagara Medical<br />
Campus. We are a founding member of the Campus together with our neighbors Roswell Park<br />
Cancer <strong>Institute</strong>, Kaleida, <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>, and the <strong>Buffalo</strong> Medical Group. For more than half a<br />
century, HWI scientists have been committed to improving human health through study, <strong>at</strong> the molecular<br />
level, of the causes and potential cures of many diseases. In contrast to clinical research, the focus<br />
of <strong>Hauptman</strong>-<strong>Woodward</strong>’s basic research is to determine the structures of individual substances such<br />
as proteins th<strong>at</strong> play a role in life’s processes and the development of specific diseases.<br />
Working under the leadership of Nobel Laure<strong>at</strong>e Herbert <strong>Hauptman</strong>, HWI scientists use the techniques<br />
of molecular biology, biochemistry, and crystallography to promote the understanding, tre<strong>at</strong>ment and<br />
prevention of specific human diseases, to aid in r<strong>at</strong>ional drug design, and to train research scientists. In<br />
addition, other research on-going <strong>at</strong> HWI seeks to improve the methods of crystalliz<strong>at</strong>ion and d<strong>at</strong>a<br />
analysis used for molecular structure determin<strong>at</strong>ion by scientists worldwide.<br />
Inside …<br />
President’s Message<br />
Chief Executive Officer’s Message<br />
Audited Financial St<strong>at</strong>ements<br />
<strong>Hauptman</strong>-<strong>Woodward</strong> Medical Research <strong>Institute</strong>, Inc.<br />
<strong>Hauptman</strong>-<strong>Woodward</strong> Found<strong>at</strong>ion<br />
The Faces of Science<br />
On <strong>Hauptman</strong>-<strong>Woodward</strong>’s Boards<br />
At <strong>Hauptman</strong>-<strong>Woodward</strong><br />
Our Dedic<strong>at</strong>ed Donors<br />
Select Public<strong>at</strong>ions<br />
<strong>2006</strong> ANNUAL REPORT
PRESIDENT’S MESSAGE .... CHIEF EXECUTIVE OFFICER’S MESSAGE ...<br />
Passion pushes progress. Hyp<strong>at</strong>ia, the philosopher, astronomer and m<strong>at</strong>hem<strong>at</strong>ician paid<br />
the ultim<strong>at</strong>e price for her passion and yet her teachings lived on. The daughter of Theon of<br />
Alexandria, a teacher of m<strong>at</strong>hem<strong>at</strong>ics with the Museum of Alexandria in Egypt, Hyp<strong>at</strong>ia<br />
studied with her f<strong>at</strong>her, and with many others including Plutarch the Younger. She herself<br />
taught <strong>at</strong> the Neopl<strong>at</strong>onist school of philosophy where she l<strong>at</strong>er was the salaried director.<br />
She probably wrote on m<strong>at</strong>hem<strong>at</strong>ics, astronomy and philosophy, including on the motions<br />
of the planets, about number theory and about conic sections. She corresponded with and<br />
hosted scholars from other cities. She was a popular lecturer, drawing students from many<br />
parts of the Greek empire.<br />
From the little historical inform<strong>at</strong>ion about Hyp<strong>at</strong>ia th<strong>at</strong> survives, it appears th<strong>at</strong> she invented<br />
the plane astrolabe, the gradu<strong>at</strong>ed brass hydrometer and the hydroscope. She dressed in the<br />
clothing of a scholar, r<strong>at</strong>her than in women's clothing and moved about freely, driving her<br />
own chariot, contrary to the norm for women's public behavior. She exerted considerable<br />
political influence in the city.<br />
The new Christian bishop, Cyril, a future saint objected to Hyp<strong>at</strong>ia on a number of counts: she represented heretical<br />
teachings, including experimental science and pagan religion. And she was a woman who didn't know her place. Cyril's<br />
preaching against Hyp<strong>at</strong>ia is said to have been wh<strong>at</strong> incited a mob led by fan<strong>at</strong>ical Christian monks to <strong>at</strong>tack her as she<br />
drove her chariot through Alexandria. They dragged her from her chariot, stripped her, killed her, stripped her flesh from<br />
her bones, sc<strong>at</strong>tered her body parts through the streets, and burned some remaining parts of her body in the library of<br />
Caesareum. Her students fled to Athens, where the study of m<strong>at</strong>hem<strong>at</strong>ics flourished.<br />
Hyaptia’s passion for the sciences and m<strong>at</strong>hem<strong>at</strong>ics was unorthodox <strong>at</strong> th<strong>at</strong> time. She pushed the boundaries and she<br />
was fueled by her passion and she paid the ultim<strong>at</strong>e price.<br />
Our scientists too are driven by a passion – the passion to achieve a gre<strong>at</strong>er understanding of our science. They too make<br />
sacrifices for their passion and I continue to be awed and impressed by the commitment of time, energy and cre<strong>at</strong>ivity our<br />
scientific and non-scientific staff brings to the table each day as they try to advance their science and build the strength<br />
and success of <strong>Hauptman</strong>-<strong>Woodward</strong>. You will meet each of these terrific HWI employees on the following pages.<br />
As most of you probably know by now, our current CEO, George DeTitta, is making his choice to return next year fulltime<br />
to his truest passion by returning to his lab. I commend him for the leadership he has provided the <strong>Institute</strong> during<br />
his tenure and I commend him for having the conviction to be where his passion lies – in the lab. George’s leadership<br />
will leave a legacy and a found<strong>at</strong>ion which the succeeding CEO can build upon for future, and perhaps, even gre<strong>at</strong>er<br />
successes supported by the stable core of scientists and staff members who are the fabric of this facility.<br />
Of course, I would be remiss not to acknowledge the passion th<strong>at</strong> drives our friends and donors to continue to support us<br />
in our effort to succeed and not simply survive. To our core supporters, I thank you on behalf of the <strong>Institute</strong> because you<br />
too play an essential role in improving human health.<br />
The combined passion of our scientists, our staff, our leaders, current and future, and our stalwart supporters also will<br />
push our continuing progress for many tomorrows to come.<br />
Herbert A. <strong>Hauptman</strong>, Ph.D., Nobel Laure<strong>at</strong>e<br />
President<br />
The ties th<strong>at</strong> bind us and the passion th<strong>at</strong> inspires us …<br />
I have often heard Herb speak about how his passion for science and m<strong>at</strong>h began as a<br />
very young child … I have heard some of the young scientists reminisce about how their<br />
curiosity has made the lab their second home … I have listened to our CFO discuss<br />
balance sheets with a level of excitement only known to accountants … I have observed<br />
our other support staff be wrapped up in a love of wh<strong>at</strong> they do and I know myself th<strong>at</strong><br />
it is a love of wh<strong>at</strong> I do in the lab and the immense respect and appreci<strong>at</strong>ion I have for<br />
my colleagues th<strong>at</strong> draws me to the lab each day.<br />
And it is th<strong>at</strong> drive and curiosity about how we can do it better and the discoveries th<strong>at</strong><br />
we can make to improve our science th<strong>at</strong> has further strengthened my resolve to complete<br />
my term as HWI CEO as of April 1, 2008.<br />
It has been an eventful and wonderful ride in the CEO chair during a time of gre<strong>at</strong><br />
change and growth, and I am honored to have led and to continue to lead such a<br />
tremendously talented and dedic<strong>at</strong>ed group of staff members – scientists and nonscientists<br />
alike.<br />
I will approach the next year with the same outlook as my entire time in office – I will be<br />
mentor, manager and ultim<strong>at</strong>e decision-maker for this organiz<strong>at</strong>ion until I formally hand<br />
over the reins to my yet-to-be-chosen successor. I will enjoy this last year as HWI CEO<br />
and then on April 1, 2008, I will happily enjoy returning full-time to my science.<br />
I hope each of you will approach the next year with th<strong>at</strong> same interactive and mutually<br />
supportive spirit which has brought us into the second 50 years of our existence. Our<br />
scientists, administr<strong>at</strong>ors, board members and community backers – I thank you for the<br />
past year and invite you to reinvigor<strong>at</strong>e your passion for HWI so we can firmly position<br />
our science <strong>at</strong> the forefront of our field for the foreseeable future. I look forward to our<br />
continued work together in the pursuit of scientific discovery. Whether you are growing<br />
proteins, crystallizing them, developing new and better methods to do our science,<br />
doing one of the many jobs th<strong>at</strong> help make it possible for all of the scientists to focus on<br />
the work in their labs, serving as a community ambassador or helping fund this critical<br />
work – you are an essential part of this process. Thank you.<br />
Sincerely,<br />
George DeTitta, Ph.D.<br />
Chief Executive Officer and Executive Director
FINANCIAL STATEMENTS<br />
HAUPTMAN-WOODWARD MEDICAL RESEARCH INSTITUTE<br />
STATEMENT OF FINANCIAL POSITION *<br />
OCTOBER 31, <strong>2006</strong><br />
ASSETS<br />
Current assets:<br />
Cash $ 149,763<br />
Pledges receivable, net 2,052,098<br />
Grants receivable-capital campaign 222,286<br />
Grants receivable-science 743,621<br />
Prepaid Expense 30,054<br />
Total current assets 3,197,822<br />
Investments: 5,652,468<br />
Fixed assets:<br />
Land, building and equipment, net 23,831,185<br />
Construction in progress 367,000<br />
24,198,185<br />
Other assets:<br />
Pledges receivable, net 1,491,681<br />
Deferred financing fees, net 706,305<br />
Assets held in charitable trust 356,824<br />
Swap contract 36,416<br />
Interest in net assets of <strong>Hauptman</strong>-<strong>Woodward</strong> Found<strong>at</strong>ion 163,345<br />
2,754,571<br />
Total assets $35,803,046<br />
LIABILITIES AND NET ASSETS<br />
Current liabilities:<br />
Accounts payable - oper<strong>at</strong>ing $ 503,407<br />
Accounts payable - construction-in-progress 148,000<br />
Accrued payroll and rel<strong>at</strong>ed taxes 149,408<br />
Refundable advances 24,054<br />
Capital lease oblig<strong>at</strong>ions -<br />
Bonds payable - current portion 185,000<br />
Total current liabilities 1,009,869<br />
Bonds payable 6,600,000<br />
Total liabilities 7,609,869<br />
Net assets:<br />
Unrestricted 20,679,637<br />
Unrestricted-design<strong>at</strong>ed 200,000<br />
Temporarily restricted 6,580,297<br />
Permanently restricted 733,243<br />
Total net assets 28,193,177<br />
Total liabilities and net assets $35,803,046<br />
* This inform<strong>at</strong>ion has been taken from the audited financial st<strong>at</strong>ements of<br />
<strong>Hauptman</strong>-<strong>Woodward</strong> Medical Research <strong>Institute</strong> for the fiscal year ending October 31, <strong>2006</strong><br />
HAUPTMAN-WOODWARD FOUNDATION<br />
STATEMENT OF FINANCIAL POSITION *<br />
OCTOBER 31, <strong>2006</strong><br />
ASSETS<br />
Current assets: $ 106,753<br />
Pledges receivable, net 52,913<br />
Prepaid Expense 1,300<br />
Total current assets 160,966<br />
Investments 21,273<br />
Total assets $182,239<br />
LIABILITIES AND NET ASSETS<br />
Current liabilities:<br />
Accounts payable $ 17,313<br />
Accrued payroll and rel<strong>at</strong>ed taxes 1,581<br />
Total current liabilities 18,894<br />
Net assets:<br />
Unrestricted 128,086<br />
Temporarily restricted 35,259<br />
Total net assets 163,345<br />
Total liabilities and net assets $ 182,239<br />
* This inform<strong>at</strong>ion has been taken from the audited financial st<strong>at</strong>ements of<br />
<strong>Hauptman</strong>-<strong>Woodward</strong> Found<strong>at</strong>ion for the fiscal year ending October 31, <strong>2006</strong>
THE FACES OF SCIENCE AT HWI BOARD OF DIRECTORS AND OFFICERS<br />
“Our unique environment, intern<strong>at</strong>ional reput<strong>at</strong>ion and st<strong>at</strong>e-ofthe-art<br />
biomedical research facility have enabled us to consistently<br />
<strong>at</strong>tract outstanding scientific talent to HWI. In fact, we are<br />
in the enviable position of always having an overabundance of<br />
top-notch candid<strong>at</strong>es who want to work <strong>at</strong> HWI. It is these future<br />
HWI scientists, in collabor<strong>at</strong>ion with our current scientists who will<br />
ensure our continued success. Our scientists, and staff members<br />
are the true found<strong>at</strong>on of this institute.” ~ George T. DeTitta, Ph.D.<br />
The People of the <strong>Hauptman</strong>-<strong>Woodward</strong> Medical Research <strong>Institute</strong><br />
Our gre<strong>at</strong>est assets are our people. <strong>Hauptman</strong>-<strong>Woodward</strong> is fortun<strong>at</strong>e to be home to some of the<br />
most cre<strong>at</strong>ive minds in science today and has the distinction of offering an investig<strong>at</strong>or-initi<strong>at</strong>ed<br />
approach th<strong>at</strong> allows our scientists to transl<strong>at</strong>e their passion for their work into their everyday experiences.<br />
The scientific team is supported daily by talented individuals who serve on our boards and a<br />
staff which includes individuals with a wide range of talents and experiences. Each employee <strong>at</strong><br />
<strong>Hauptman</strong>-<strong>Woodward</strong> plays a role in ensuring the organiz<strong>at</strong>ion’s current and future successes.<br />
Donald A. Hess<br />
Chairman of the Board<br />
Paul J. Koessler<br />
Vice Chairman of the Board<br />
Christopher T. Greene<br />
Chairman of the Found<strong>at</strong>ion Board<br />
Elizabeth S. Mitchell<br />
Vice Chairman of the Found<strong>at</strong>ion Board<br />
Board of Directors and Officers<br />
Donald A. Hess<br />
(Chairman)<br />
Paul J. Koessler<br />
(Vice Chairman)<br />
Herbert A. <strong>Hauptman</strong>, Ph.D.<br />
(President)<br />
George T. DeTitta, Ph.D.<br />
(Executive Director and CEO)<br />
Walter A. Pangborn, Ph.D.<br />
(Executive Vice President)<br />
James R. Biltekoff<br />
(Treasurer and Chairman,<br />
Finance Committee)<br />
Elizabeth S. Mitchell<br />
(Secretary)<br />
Lisa Foti Milk, CPA<br />
(CFO and Assistant Treasurer)<br />
Adelbert Fleischmann<br />
(Co-Counsel)<br />
Michele O. Heffernan<br />
(Co-Counsel)<br />
Cynthia Ambres, M.D.<br />
Richard Aubrecht<br />
Norbert A. Bennett<br />
Alan L. Dressler<br />
Robert Glenning<br />
Christopher T. Greene<br />
David C. Hohn, M.D.<br />
Robert J. A. Irwin<br />
William L. Joyce<br />
Elizabeth C. Marks<br />
Anthony M. Masiello<br />
Lewis D. McCauley<br />
Peter T. Ostrow, M.D., Ph.D.<br />
P<strong>at</strong>rick Reilly<br />
Richard W. Shaughnessy<br />
Walter F. Stafford, III, Ph.D.<br />
Andrew M. Gulick, Ph.D.<br />
(Chairman,Scientific Governance Council)<br />
Found<strong>at</strong>ion Board<br />
Christopher T. Greene<br />
(Chairman)<br />
Elizabeth S. Mitchell<br />
(Vice Chairman)<br />
George T. DeTitta, Ph.D.<br />
(Executive Director and CEO)<br />
Elizabeth C. Marks<br />
(Secretary)<br />
James R. Biltekoff<br />
(Treasurer)<br />
Jennifer J. Daniels<br />
Nancy L. Dowdell<br />
Alan L. Dressler<br />
Christopher G. Gibas<br />
Jane F. Griffin, Ph.D.<br />
Eva M. Hassett<br />
Herbert A. <strong>Hauptman</strong>, Ph.D.<br />
Donald A. Hess<br />
Paul J. Koessler<br />
Richard W. Shaughnessy<br />
Emeritus Directors<br />
Alan P. Bagley<br />
Thomas R. Beecher Jr.<br />
Constance S. Constantine<br />
James R. Kanski, M.D.<br />
Charles A. Martin, Jr.<br />
Donald F. Newman<br />
Albert J. Wright, III
LEADERSHIP<br />
Herbert A. <strong>Hauptman</strong>, Ph.D.<br />
Position: Principal Research Scientist & President<br />
Appointments: He is a Distinguished Professor in the UB Department of Structural Biology, an Adjunct Professor in UB’s<br />
Department of Computer Science and Engineering, and a Research Professor in the UB Department of Biophysical<br />
Sciences.<br />
Research: As a m<strong>at</strong>hem<strong>at</strong>ician, Dr. <strong>Hauptman</strong> is interested in the development of m<strong>at</strong>hem<strong>at</strong>ical methods to determine the<br />
structures of biologically important substances. His current work builds on his Nobel-winning 'direct methods' research.<br />
Current projects are extending the methods of structure determin<strong>at</strong>ion to macromolecules, such as proteins, th<strong>at</strong> are<br />
models for drug design, and the extension of his methods from traditional X-ray diffraction to the advanced technique of<br />
neutron diffraction. A computer program, SnB, has been developed and continues to be refined. Dr. <strong>Hauptman</strong> also<br />
spends time mentoring and educ<strong>at</strong>ing others locally and globally about science and basic biomedical research.<br />
Educ<strong>at</strong>ion: Received his B.S., M.A., and Ph.D. in M<strong>at</strong>hem<strong>at</strong>ics from the City College of New York, Columbia <strong>University</strong>,<br />
and the <strong>University</strong> of Maryland, respectively.<br />
Noteworthy Contributions: Dr. <strong>Hauptman</strong> received the Nobel Prize in Chemistry in 1985 for his development of the<br />
m<strong>at</strong>hem<strong>at</strong>ical technique known as “direct methods.” He is a member of the N<strong>at</strong>ional Academy of Sciences since 1988<br />
and has received the City of <strong>Buffalo</strong>’s 1995 Citizen of Distinction, Western New York Man of the Year Award from the<br />
<strong>Buffalo</strong> Chamber of Commerce in 1986, and Citizen of the Year Award from the <strong>Buffalo</strong> Evening News in 1986. In<br />
addition, he has received honorary degrees from 11 colleges and universities around the world. Most recently, <strong>Hauptman</strong><br />
received a prestigious grant from The Intern<strong>at</strong>ional Human Frontier Science Program Organiz<strong>at</strong>ion (HFSPO) for<br />
a multin<strong>at</strong>ional, multidisciplinary project researching neutron diffraction. The grant is so prestigious than only a handful<br />
of projects are even invited to apply – and of the 54 accepted applic<strong>at</strong>ions, this project was ranked number one.<br />
George T. DeTitta, Ph.D.<br />
Position: Principal Research Scientist, Executive Director &<br />
Chief Executive Officer<br />
Appointments: He is a Professor and Department Chair for<br />
the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>’s Department of Structural Biology, a<br />
Research Professor in the Department of Chemistry <strong>at</strong> UB, and<br />
a member of the Molecular and Cell Biology Department &<br />
Pharmacology and Experimental Therapeutics Department <strong>at</strong><br />
the Roswell Park Cancer <strong>Institute</strong>.<br />
Research: Current research focuses on the macromolecular<br />
crystalliz<strong>at</strong>ion problem and the development of innov<strong>at</strong>ive methods<br />
and techniques to improve crystal growth. Dr. DeTitta also<br />
spends time focusing on the growth of the medical research<br />
efforts <strong>at</strong> HWI and in Western New York, and on initi<strong>at</strong>ing<br />
collabor<strong>at</strong>ive projects with scientists <strong>at</strong> several local institutions.<br />
Educ<strong>at</strong>ion: Dr. DeTitta received his B.S. in Chemistry from Villanova <strong>University</strong> and his Ph.D. in Crystallography and<br />
Biochemistry from the <strong>University</strong> of Pittsburgh.<br />
Noteworthy Contributions: He has been directly involved in projects with NASA and is co-inventor of two p<strong>at</strong>ented<br />
devices for growing crystals. His team’s most recent high throughput robotics work has earned them partnerships in<br />
two genomics consortium, Northeast Structural Genomics and Structural Genomics of P<strong>at</strong>hogenic Protozoa. His work<br />
in the crystal growth arena has earned him worldwide recognition spurring invited speaking engagements within the<br />
U.S. and abroad. In 2005, his lab earned a $17.1 million NIH grant to fund a Center for High-Throughput Structural<br />
Biology, making his lab one of ten n<strong>at</strong>ionally funded centers th<strong>at</strong> are part of the N<strong>at</strong>ional <strong>Institute</strong>s of General Medical<br />
Sciences Protein Structure Initi<strong>at</strong>ive.<br />
Walter A. Pangborn, Ph.D.<br />
Position: Principal Research Scientist & Executive Vice President<br />
Appointments: He is an Associ<strong>at</strong>e Professor in the Department of<br />
Structural Biology <strong>at</strong> the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Research: Dr. Pangborn is currently involved in X-ray diffraction<br />
analysis and d<strong>at</strong>a collection of crystal structures using X-ray Area<br />
Detectors. His d<strong>at</strong>a collection and analysis work encompasses<br />
proteins, steroids, killer toxins and antibiotics rel<strong>at</strong>ed to many<br />
diseases. Dr. Pangborn headed the efforts for the construction of our<br />
new research facility. Also, he is involved in the design and construction<br />
of a beam-line simul<strong>at</strong>or in the x-ray diffraction labor<strong>at</strong>ory.<br />
Educ<strong>at</strong>ion: He received his B.S. in Chemistry from Providence<br />
College and his Ph.D. in Biophysics from the <strong>University</strong> of Maryland,<br />
School of Medicine.<br />
Noteworthy Contributions: Public<strong>at</strong>ions include more than 190 papers, abstracts, and chapters. He also collabor<strong>at</strong>es<br />
with several organiz<strong>at</strong>ions across the United St<strong>at</strong>es including the Stanford Synchrotron Research Labor<strong>at</strong>ory and the<br />
Cornell High Energy Synchrotron Source.
DISTINGUISHED & PRINCIPAL RESEARCH SCIENTISTS<br />
Vivian Cody, Ph.D.<br />
Position: Principal Research Scientist<br />
Appointments: At the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>, Dr. Cody is a Professor in the Department of Structural Biology, a Research<br />
Professor of Medicine, School of Medicine, an Associ<strong>at</strong>e Research Professor, Department of Molecular and Cellular-<br />
Biophysics and Biochemistry, Roswell Park Gradu<strong>at</strong>e Division.<br />
Research: Dr. Cody’s research focuses on cancer, thyroid disorders, and AIDS-rel<strong>at</strong>ed diseases. More specifically, she<br />
uses X-ray crystallography and computer graphics methods to determine molecular details of protein crystals. This allows<br />
new anticancer and antipneumocystis agents to be developed to fight P.c. pneumonia. She also investig<strong>at</strong>es the molecular<br />
level details of thyroid hormone function.<br />
Educ<strong>at</strong>ion: She received her B.S. and Ph.D. in Chemistry from the <strong>University</strong> of Michigan and the <strong>University</strong> of Cincinn<strong>at</strong>i,<br />
respectively.<br />
Noteworthy Contributions: Her public<strong>at</strong>ions include more than 500 papers, abstracts, chapters, books, and reviews.<br />
She has been a member of HWI’s staff since 1970 and is a leader in Zonta Intern<strong>at</strong>ional, a women’s service organiz<strong>at</strong>ion.<br />
She was secretary of the American Crystallographic Associ<strong>at</strong>ion, 1988-94, on the Advisory Committee for<br />
<strong>University</strong> of North Carolina GRIP Molecular Graphics Research Resource,1990-1999, on the subcommittee for the<br />
American <strong>Institute</strong> of Physics Congressional Fellowship Selection 1991-1997 and served as chairman, 1994-1997.<br />
She also served on the Editorial Board for Endocrinology 1993-2000, received an Award for Western New York<br />
Health Care Technology/ Discovery, 1994, editor, J. Molecular Graphics, 1995-1998, received the Award for New<br />
York St<strong>at</strong>e Sen<strong>at</strong>e, Woman of Distinction 2001, received the YWCA Leadership Award-Professions, 2002, Editorial<br />
Board Member, Journal of Biological Chemistry, July 2003-2008, Erie County Woman of Distinction, Women’s<br />
History Month Billboard, March 2003, member of ADDT Study Section, June 2004-2008, Women of Achievement,<br />
2004 <strong>Buffalo</strong> Chapter American Associ<strong>at</strong>ion of <strong>University</strong> Women, and also received the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong><br />
Sustained Achievement Award, 2005.<br />
William L. Duax, Ph.D.<br />
Position: H.A. <strong>Hauptman</strong> Distinguished Scientist<br />
Appointments: Dr. Duax is a Professor in the Department of Structural<br />
Biology <strong>at</strong> the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Research: Dr. Duax’s current research is on the areas of bioinform<strong>at</strong>ics,<br />
proteomics, and genomics. He is predicting the structure<br />
and function of 5000 hypothetical genes th<strong>at</strong> are members of the<br />
steroid dehydrogenase family. Members of th<strong>at</strong> family of enzymes<br />
are implic<strong>at</strong>ed in the etiology of cancer, high blood pressure,<br />
Alzheimer’s disease, artherosclerosis, and polycystic kidney<br />
disease. Through analysis of the system of these 5000 proteins and<br />
the genes th<strong>at</strong> express them, he is tracing the evolution of the<br />
genetic code to its origin over three billion years ago. He is testing<br />
his predictions using the technique he applied in the past to determine<br />
the molecular basis for the action of hormone drugs and<br />
antibiotics.<br />
Educ<strong>at</strong>ion: He received his B.A. in Chemistry from St. Ambrose College and his Ph.D. in Physical Chemistry from the<br />
<strong>University</strong> of Iowa.<br />
Noteworthy Contributions: Dr. Duax is a recipient of MERIT (Method of Extended Research in Time) Award from the<br />
N<strong>at</strong>ional <strong>Institute</strong>s of Health from 1987 to 1995. He also received the Distinguished Scientific Award from the Clinical<br />
Ligand Society in 1995 and an honorary degree from the <strong>University</strong> of Lodz in Poland in 1999. He has been an<br />
invited lecturer <strong>at</strong> more than 180 universities, meetings, institutions, and conferences. His research also has uncovered<br />
the mystery of how licorice increases blood pressure with hopes to use this knowledge to find new ways to fight the<br />
disease. He has written more than 270 public<strong>at</strong>ions, 56 chapters and written or edited four books. He is past president<br />
of the Intern<strong>at</strong>ional Union of Crystallography (IUCr), an organiz<strong>at</strong>ion of more than 15,000 crystallographers throughout<br />
the world and is the founding editor of the quarterly newsletter of the IUCr<br />
Jane F. Griffin, Ph.D.<br />
Position: Principal Research Scientist and Director of Summer<br />
Internship Program<br />
Appointments: Dr. Griffin is an Associ<strong>at</strong>e Professor in the <strong>University</strong><br />
<strong>at</strong> <strong>Buffalo</strong>’s Structural Biology Department.<br />
She sits on several boards including the Western New York Technology<br />
Development Center (INSYTE) and Holy Angels Academy.<br />
Research: Research interests include the structure function rel<strong>at</strong>ionships<br />
in steroids and opi<strong>at</strong>es and the use of crystallographic d<strong>at</strong>abases<br />
in scientific studies.<br />
Educ<strong>at</strong>ion: Dr. Griffin received her B.A. in Chemistry from<br />
D’Youville College and her Ph.D. in Chemistry from the <strong>University</strong><br />
<strong>at</strong> <strong>Buffalo</strong><br />
Noteworthy Contributions: In 1996, she was honored with the Distinguished Alumni Award from the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
In addition to serving as Treasurer of the American Crystallographic Associ<strong>at</strong>ion (ACA) from 1995 to 2001, she received the<br />
ACA Service Award in 1991. She leads a Political Action Committee which is devoted to promoting and supporting women<br />
who run for political office on a local and st<strong>at</strong>e level. She previously headed the Molecular Biophysics Department <strong>at</strong> HWI.
SENIOR RESEARCH SCIENTISTS<br />
Robert H. Blessing, Ph.D.<br />
Position: Senior Research Scientist<br />
Appointments: Dr. Blessing holds two positions <strong>at</strong> the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>, Professor in the<br />
Department of Structural Biology and Research Professor in the Department of Chemistry.<br />
He is also Director of Gradu<strong>at</strong>e Studies in the Structural Biology Department.<br />
Research: Dr. Blessing’s research focuses on experimental and comput<strong>at</strong>ional techniques<br />
for <strong>at</strong>taining high accuracy in both crystallographic diffraction measurements and<br />
crystal structure analyses. His interests include electron density distributions and chemical<br />
bonding in molecules and crystals and the crystallographic phase problem.<br />
Educ<strong>at</strong>ion: He received his B.S. in Chemistry from King’s College and his Ph.D. in<br />
Inorganic and Physical Chemistry from Ohio <strong>University</strong>.<br />
Noteworthy Contributions: Dr. Blessing has been an invited lecturer <strong>at</strong> universities in<br />
Denmark, France, Germany, Ireland, Italy and Spain. His public<strong>at</strong>ions include more<br />
than 130 abstracts, reviews, chapters, and peer-reviewed research papers.<br />
Daniel T. Gewirth, Ph.D.<br />
Position: Senior Research Scientist<br />
Appointments: He is an Associ<strong>at</strong>e Professor in the Department of Structural Biology <strong>at</strong><br />
the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Research: Dr. Gewirth is interested in structural studies of Hsp90 chaperones, drug<br />
design, protein folding; nuclear hormone receptors and basal transcription factors.<br />
Educ<strong>at</strong>ion: He received his B.S. in Chemistry from the <strong>University</strong> of Chicago and<br />
earned his Ph.D. in Molecular Biophysics and Biochemistry from Yale <strong>University</strong>.<br />
Noteworthy Contributions: Dr. Gewirth’s public<strong>at</strong>ions include more than 20 papers<br />
and reviews.<br />
Debashis Ghosh, Ph.D.<br />
Position: Senior Research Scientist<br />
Appointments: He is an Associ<strong>at</strong>e Professor in the Department of Molecular and<br />
Cellular Biophysics, Roswell Park Gradu<strong>at</strong>e Division of the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong> and<br />
an Associ<strong>at</strong>e Professor in the <strong>University</strong>’s Department of Structural Biology.<br />
Research: Dr. Ghosh is interested in the structural endocrinology of estrogen synthesis<br />
and metabolism as well as breast cancer drug design. Currently, he is investig<strong>at</strong>ing<br />
three enzymes th<strong>at</strong> play a critical role in controlling the active level of estrogen in breast<br />
tissue, vital targets for anti-breast cancer drugs.<br />
Educ<strong>at</strong>ion: He received his B.S. in Physics, Chemistry, and M<strong>at</strong>hem<strong>at</strong>ics from St.<br />
Xavier’s College and earned his M.S. in Physics and his M.Sc. in Biophysics from the<br />
Indian <strong>Institute</strong> of Technology and the Saha <strong>Institute</strong> of Nuclear Physics, respectively.<br />
Upon leaving India, he completed his Ph.D. <strong>at</strong> the <strong>University</strong> of Pittsburgh in Crystallography<br />
and his post-doctoral work <strong>at</strong> Carnegie-Mellon <strong>University</strong>.<br />
Noteworthy Contributions: Dr. Ghosh is a Cancer Research Scientist and Associ<strong>at</strong>e<br />
Member <strong>at</strong> the Roswell Park Cancer <strong>Institute</strong>.<br />
David A. Langs, Ph.D.<br />
Position: Senior Research Scientist<br />
Appointments: He serves as an Associ<strong>at</strong>e Professor in the Department of Structural<br />
Biology.<br />
Research: Longtime interests include both the structure and function of ion channels<br />
and methods of crystal structure determin<strong>at</strong>ion. His specialty lies in solving structures<br />
others have previously found intractable. Currently he is developing methods for ab<br />
initio, and SIR and SAS phasing <strong>at</strong> low resolution.<br />
Educ<strong>at</strong>ion: Dr. Langs received his B.S. in Chemistry from St. Bonaventure <strong>University</strong><br />
and his Ph.D. in Inorganic Chemistry from the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Noteworthy Contributions: He helped solve the crystal structure and mode of action<br />
of the antibiotic gramicidin A, and published the first detailed molecular-level model<br />
for the nifedipine binding site of the voltage-g<strong>at</strong>ed Calcium channel. His public<strong>at</strong>ions<br />
include more than 200 papers, chapters and abstracts.<br />
Vladimir Z. Pletnev, Ph.D.<br />
Position: Senior Research Scientist<br />
Appointments: Dr. Pletnev serves as Head of the X-ray Labor<strong>at</strong>ory <strong>at</strong> the Russian<br />
Academy of Sciences, <strong>Institute</strong> of Bioorganic Chemistry in Moscow.<br />
Research: Dr. Pletnev’s research interests include studying the three-dimensional organiz<strong>at</strong>ion,<br />
structure-function rel<strong>at</strong>ionship, and molecular mechanism of protein-peptide<br />
n<strong>at</strong>ure compounds using x-ray, molecular mechanics/dynamic/graphics, and bioinform<strong>at</strong>ics<br />
methods. Current proteins under examin<strong>at</strong>ion include short chain dehydrogenases,<br />
antibodies, and florescent proteins.<br />
Educ<strong>at</strong>ion: He received his M.S. in Chemistry from the Mendeleev <strong>Institute</strong> of Chemistry<br />
and Technology in Moscow and his Ph.D. in Bioorganic Chemistry and D.Sc. in<br />
Crystallography from the USSR Academy of Sciences in Moscow.<br />
Noteworthy Contributions: His public<strong>at</strong>ions include over 250 papers, chapters, and<br />
abstracts.<br />
Charles M. Weeks, Ph.D.<br />
Position: Senior Research Scientist<br />
Appointments: Dr. Weeks is a Professor in the Department of Structural Biology <strong>at</strong> the<br />
<strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Research: His research includes the refinement of direct methods to determine the<br />
structure of macromolecules. He has developed the computer programs SnB and BnP<br />
th<strong>at</strong> implement the Shake-and-Bake method for solving molecular structures from<br />
crystallographic d<strong>at</strong>a.<br />
Educ<strong>at</strong>ion: Dr. Weeks received his B.S. in Biochemistry from Cornell <strong>University</strong> and his<br />
Ph.D. in Biophysics from the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Noteworthy Contributions: Public<strong>at</strong>ions include over 280 papers, abstracts, and<br />
chapters. He has also been an invited lecturer <strong>at</strong> over 35 n<strong>at</strong>ional and intern<strong>at</strong>ional<br />
meetings and symposia.<br />
6 7
RESEARCH SCIENTISTS<br />
Barnali (Neel) Chaudhuri, Ph.D.<br />
Position: Research Scientist<br />
Appointments: She serves as an Assistant Professor in the Department of Structural<br />
Biology <strong>at</strong> the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Research: Dr Chaudhuri's research is aimed <strong>at</strong> understanding the enzym<strong>at</strong>ic processing<br />
of the anticodon domains of the tRNAs. Given the central role of decoding events<br />
in cellular physiology, very little is understood about the enzym<strong>at</strong>ic targeting and<br />
processing of the tRNA anticodons. Therefore, Dr. Chaudhuri’s lab is studying the<br />
mechanism of these molecular recognition events. She also is interested in designing<br />
nano-sized molecular assemblies using protein modules as building blocks.<br />
Educ<strong>at</strong>ion: She received her Ph.D. in Molecular Biology from Uppsala <strong>University</strong> in Sweden.<br />
Andrew M. Gulick, Ph.D.<br />
Position: Research Scientist<br />
Appointments: He serves as an Assistant Professor in the Department of Structural<br />
Biology <strong>at</strong> the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Research: Dr. Gulick uses X-ray crystallography to determine the molecular mechanisms<br />
th<strong>at</strong> enzymes use to c<strong>at</strong>alyze, or speed up, chemical reactions. His current research focuses<br />
on a family of large multi-domain enzymes th<strong>at</strong> synthesize peptides th<strong>at</strong> have antibiotic<br />
and anti-cancer activities. Members of this family also work with other proteins to make<br />
important molecules th<strong>at</strong> bacteria need to establish an infection in a susceptible host. An<br />
understanding of the structures and functions of these proteins will provide insights th<strong>at</strong><br />
may lead to the development of novel inhibitors th<strong>at</strong> could be used as anti-infective agents.<br />
Educ<strong>at</strong>ion: He received his B.S. in Biochemistry from Brown <strong>University</strong> and his Ph.D. in<br />
Experimental Oncology and Biochemistry from the <strong>University</strong> of Wisconsin-Madison.<br />
Noteworthy Contributions: Dr. Gulick has over twenty public<strong>at</strong>ions. He holds a<br />
p<strong>at</strong>ent on "Mutant Glut<strong>at</strong>hione S-Transferase Isoforms" th<strong>at</strong> were engineered to<br />
metabolize an anticancer drug.<br />
Peter J. Horn, Ph.D.<br />
Position: Research Scientist<br />
Appointments: He serves as an Assistant Professor for the Department of Structural<br />
Biology <strong>at</strong> the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Research: His current work is centered on heterochrom<strong>at</strong>in organiz<strong>at</strong>ion and its regul<strong>at</strong>ion<br />
by a cullin-dependent ubiquitin ligase. This cullin family is widely conserved in<br />
many species, plays diverse nuclear roles, and is over-expressed or mis-regul<strong>at</strong>ed in<br />
some human cancers and genetic disorders. The current focus is on identifying its structural<br />
composition, wh<strong>at</strong> its substr<strong>at</strong>es might be, and how those substr<strong>at</strong>es are recognized<br />
by the enzyme. These studies will be critical to understanding how this enzyme<br />
particip<strong>at</strong>es in chromosome segreg<strong>at</strong>ion, DNA repair, and the progression of cancer.<br />
Educ<strong>at</strong>ion: Dr. Horn received a B.A. and M.S. in Biochemistry from Case Western<br />
Reserve <strong>University</strong> and his Ph.D. in Biochemistry from Michigan St<strong>at</strong>e <strong>University</strong>.<br />
Noteworthy Contributions: He was the first to show th<strong>at</strong> ubiquitinyl<strong>at</strong>ion regul<strong>at</strong>es<br />
heterochrom<strong>at</strong>in form<strong>at</strong>ion.<br />
Joseph R. Luft<br />
Position: Research Scientist<br />
Appointments: He serves as an Research Instructor in the Department of Structural<br />
Biology <strong>at</strong> the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Research: His current work deals with development of new crystalliz<strong>at</strong>ion methods and<br />
techniques which include designing equipment for enhancing crystal growth capabilities<br />
and crystallizing proteins for use in various research projects.<br />
Educ<strong>at</strong>ion: He received his B.A. in Chemistry from D’Youville College.<br />
Noteworthy Contributions: He is co-inventor of two p<strong>at</strong>ented devices for growing<br />
crystals. The most recent high throughput robotics work has earned his group partnerships<br />
in two genomics consortium, Northeast Structural Genomics and Structural<br />
Genomics of P<strong>at</strong>hogenic Protozoa. He also leads the Crystal Growth effort within the<br />
Center for High Throughput Structural Biology.<br />
Michael G. Malkowski, Ph.D.<br />
Position: Research Scientist<br />
Appointments: He is an Assistant Professor in the Department of Structural Biology <strong>at</strong><br />
the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Research: Dr. Malkowski's research interests focus on structure and functional studies<br />
of integral membrane proteins involved in lipid metabolism, f<strong>at</strong>ty acid des<strong>at</strong>ur<strong>at</strong>ion,<br />
and enzym<strong>at</strong>ic mechanisms of f<strong>at</strong>ty acid oxygen<strong>at</strong>ion. He serves as the project manager<br />
of the Center for High Throughput Structural Biology.<br />
Educ<strong>at</strong>ion: Dr. Malkowski received his B.Sc. and Ph.D. in Biochemistry from the<br />
<strong>University</strong> of Detroit and Wayne St<strong>at</strong>e <strong>University</strong>, respectively.<br />
L. Wayne Schultz, Ph.D.<br />
Position: Research Scientist<br />
Appointments: Dr. Schultz is an Assistant Professor in the Department of Structural<br />
Biology <strong>at</strong> the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Research: He is currently investig<strong>at</strong>ing the SARS virus and coronavirus replic<strong>at</strong>ion and<br />
virus-host protein interactions, bioluminescence and cellular oxygen sensing.<br />
Educ<strong>at</strong>ion: Dr. Schultz received his B.A. in Chemistry from the College of Wooster and<br />
his M.S. and Ph.D., respectively in Analytical Chemistry and Biophysical Chemistry<br />
from Cornell <strong>University</strong>.<br />
Noteworthy Contributions: He holds a p<strong>at</strong>ent for “Engineered Cytotoxic Ribonuclease A.”
RESEARCH SCIENTISTS POST-DOCTORAL FELLOWS<br />
Edward H. Snell, Ph.D.<br />
Position: Research Scientist<br />
Appointments: Dr. Snell is an Assistant Professor in the Department of Structural<br />
Biology <strong>at</strong> the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Research: Dr. Snell is developing experimental techniques to understand, control, and<br />
mitig<strong>at</strong>e the radi<strong>at</strong>ion damage th<strong>at</strong> occurs in X-ray crystallography studies of biological<br />
structures. Complementary to this, he is developing methods to enable a wider range of<br />
samples to be studied by neutron diffraction, a technique limited by crystal volume<br />
requirements. Ultim<strong>at</strong>ely the goal is to use a combin<strong>at</strong>ion of controlled radi<strong>at</strong>ion<br />
damage and neutron diffraction methods as techniques to resolve biological mechanisms<br />
especially where those mechanisms are redox or free-radical based.<br />
Educ<strong>at</strong>ion: Dr. Snell received his B.Sc. (Hons) in Applied Physics from John Moore<br />
<strong>University</strong> of Liverpool, UK, and his Ph.D. from the Chemistry Department of the<br />
<strong>University</strong> of Manchester, UK.<br />
Noteworthy Contributions: He holds a p<strong>at</strong>ent entitled “Method for Measurement of<br />
Physical Characteristics of Crystals.”<br />
Timothy C. Umland, Ph.D.<br />
Position: Research Scientist<br />
Appointments: He is an Assistant Professor in the Department of Structural Biology <strong>at</strong> the<br />
<strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Research: A major interest of Dr. Umland is structural studies of the severe acute respir<strong>at</strong>ory<br />
syndrome (SARS) coronavirus, with an emphasis on viral proteins involved in replic<strong>at</strong>ion<br />
and host interactions. Other interests include determining the mechanism by<br />
which members of the Hox protein family act as “master regul<strong>at</strong>ors” of cellular differenti<strong>at</strong>ion<br />
and body segment<strong>at</strong>ion, particularly during embryonic development, and the 3�<br />
-hydroxysteriod dehydrogenase's role in steroid metabolism.<br />
Educ<strong>at</strong>ion: He received his B.S. in Chemistry from the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong> and his<br />
Ph.D. in Crystallography from the <strong>University</strong> of Pittsburgh.<br />
Noteworthy Contributions: He was an invited <strong>at</strong>tendee <strong>at</strong> the 2005 N<strong>at</strong>ional Academies<br />
Keck Futures Initi<strong>at</strong>ive Conference The Genomic Revolution: Implic<strong>at</strong>ions for the Tre<strong>at</strong>ment and<br />
Control of Infectious Disease. His research also provided the first structure of tetanus neurotoxin.<br />
Hongliang Xu, Ph.D.<br />
Position: Research Scientist<br />
Appointments: He serves as an Assistant Professor in the Department of Structural<br />
Biology <strong>at</strong> the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Research: Research interests of Dr. Xu include direct methods of X-ray and neutron<br />
crystallographic phasing, comput<strong>at</strong>ional crystallography, and m<strong>at</strong>hem<strong>at</strong>ical biology.<br />
Educ<strong>at</strong>ion: Dr. Xu received both his B.S. and his M.S. in Comput<strong>at</strong>ional M<strong>at</strong>hem<strong>at</strong>ics<br />
from Peking <strong>University</strong>, and his M.S. in Industrial Engineering as well as his Ph.D. in<br />
M<strong>at</strong>hem<strong>at</strong>ics from the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Noteworthy Contributions: His public<strong>at</strong>ions include more than 70 papers, abstracts,<br />
and chapters. Dr. Xu has been an invited lecturer <strong>at</strong> 12 n<strong>at</strong>ional and intern<strong>at</strong>ioal meetings<br />
and symposia.<br />
Shaun M. Bowman, Ph.D.<br />
Educ<strong>at</strong>ion: Ph.D. and M.S. in<br />
Biological Sciences from the<br />
<strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Noteworthy Contributions:<br />
He has contributed to four<br />
public<strong>at</strong>ions.<br />
Qilong Mao, Ph.D.<br />
Educ<strong>at</strong>ion: Ph.D. in Molecular Biology and Biochemistry<br />
from the Tsinghua <strong>University</strong> in Beijing, China, M.S.<br />
in Biochemistry from the Nankai <strong>University</strong> in Tianjin,<br />
China and B.S. in Biology from the Beijing Normal<br />
<strong>University</strong> in Beijing, China.<br />
Noteworthy Contributions: He has published 11 papers.<br />
Mary Rosenblum, Ph.D.<br />
Educ<strong>at</strong>ion: Ph.D. in Chemistry from the <strong>University</strong> <strong>at</strong><br />
<strong>Buffalo</strong>, B.S. in Chemistry from Canisius College.<br />
Noteworthy Contributions: She has seven public<strong>at</strong>ions<br />
and has had an NIH postdoctoral fellowship <strong>at</strong> the<br />
<strong>University</strong> of Rochester working on Factor VIII with Dr.<br />
Phillip Fay for three years.<br />
Christopher C. Goulah, Ph.D.<br />
Educ<strong>at</strong>ion: Ph.D. in Microbiology<br />
and B.A. in Psychology<br />
from the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>.<br />
Noteworthy Contributions:<br />
He has contributed to six<br />
public<strong>at</strong>ions.<br />
Nanette L. S. Que, Ph.D.<br />
Educ<strong>at</strong>ion: Ph.D. in Chemistry from the <strong>University</strong> of<br />
Minnesota, B.S. in Chemistry from the <strong>University</strong> of the<br />
Philippines.<br />
Noteworthy Contributions: She has published more<br />
than a dozen papers and currently has a p<strong>at</strong>ent pending.<br />
Manish Shah, Ph.D.<br />
Educ<strong>at</strong>ion: Ph.D. in Drug Discovery and Structural Biology,<br />
M.S. in Applied Biomolecular Technology as well as<br />
worked <strong>at</strong> AstraZeneca Pharmaceuticals, R&D - Alderley<br />
Park, Cheshire, England as a researcher during an industrial<br />
placement from <strong>University</strong> of Nottingham in England.<br />
B.S. in Pharmacy from Karn<strong>at</strong>ak <strong>University</strong> in India.<br />
Noteworthy Contributions: He has three public<strong>at</strong>ions.
RESEARCH ASSOCIATES<br />
Margaret Cegielski<br />
Position: Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: B.S. in N<strong>at</strong>ural Sciences<br />
from Niagara <strong>University</strong><br />
Wendy A. Franke<br />
Position: Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: A.A.S. in Medical<br />
Labor<strong>at</strong>ory Technology from Erie<br />
Community College<br />
Robin Kempkes<br />
Position: Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: M.S. in Toxicology from<br />
the <strong>University</strong> of Nebraska Medical<br />
Center and a B.S. in Environmental<br />
Science from Canisius College<br />
Eric Drake<br />
Position: Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: B.S. in Biology and Animal<br />
Science from Cornell <strong>University</strong><br />
James Fang<br />
Position: Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: M.S. Peking Union Medical<br />
College, Beijing, P.R. China B.S.<br />
from Nankai, Univ., Tianjin, P.R. China<br />
Jessica Kocsis<br />
Position: Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: B.S. in Biotechnology<br />
from the Rochester <strong>Institute</strong> of<br />
Technology<br />
Mary Erman<br />
Position: Sr. Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: B.S. in Biology from<br />
D’Youville College<br />
Jennifer Griswold<br />
Position: Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: B.S. in Biotechnology<br />
from the Rochester <strong>Institute</strong> of<br />
Technology<br />
Angela Lauricella<br />
Position: Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: A.A.S. in Business<br />
Administr<strong>at</strong>ion from Erie Community<br />
College<br />
Tracy L. Lloyd<br />
Position: Sr. Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: M.S. in Biochemistry, Washington<br />
St<strong>at</strong>e <strong>University</strong> and B.S. in Molecular<br />
Biology, Millersville St<strong>at</strong>e <strong>University</strong><br />
Jennifer Smith<br />
Position: Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: B.S. in Biology from<br />
the St<strong>at</strong>e <strong>University</strong> of New York<br />
<strong>at</strong> Fredonia<br />
Jennifer Wolfley<br />
Position: Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: B.A. in Chemistry and a<br />
B.S. in Criminalistics (Forensic Chemistry)<br />
from <strong>Buffalo</strong> St<strong>at</strong>e College<br />
James Pace<br />
Position: Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: B.S. in Biology from<br />
the <strong>University</strong> of Miami<br />
Mary Elizabeth Snell<br />
Position: Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: B.S. in Chemistry and a<br />
pending M.S. in Biology from<br />
<strong>University</strong> of Alabama <strong>at</strong> Huntsville<br />
Meriem Said<br />
Position: Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: B.A. in Biophysics from<br />
John Hopkins <strong>University</strong><br />
Tina Ve<strong>at</strong>ch<br />
Position: Research Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: B.S. in Educ<strong>at</strong>ion with a<br />
concentr<strong>at</strong>ion in N<strong>at</strong>ural Sciences<br />
and Biology from the St<strong>at</strong>e <strong>University</strong><br />
of New York <strong>at</strong> Geneseo
GRADUATE STUDENTS<br />
William Bauer<br />
Position: Gradu<strong>at</strong>e Student<br />
Educ<strong>at</strong>ion: B.A. in Molecular<br />
Biology from Elmira College<br />
David Parish<br />
Position: Gradu<strong>at</strong>e Student<br />
Educ<strong>at</strong>ion: M.S. in Electrical Engineering<br />
from Stanford <strong>University</strong>, B.S. in<br />
Electrical Engineering, B.A. in M<strong>at</strong>hem<strong>at</strong>ics<br />
from the <strong>University</strong> of Washington<br />
Jesse Sundlov<br />
Position: Gradu<strong>at</strong>e Student<br />
Educ<strong>at</strong>ion: B.S. in Biology from<br />
Johns Hopkins <strong>University</strong><br />
Robert Huether<br />
Position: Gradu<strong>at</strong>e Student<br />
Educ<strong>at</strong>ion: M.A. and B.S. in Biological<br />
Science from the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong><br />
Albert Reger<br />
Position: Gradu<strong>at</strong>e Student<br />
Educ<strong>at</strong>ion: B.S. in Biology from<br />
Niagara <strong>University</strong><br />
Alex Vecchio<br />
Position: Gradu<strong>at</strong>e Student<br />
Educ<strong>at</strong>ion: B.S. in Biology from<br />
Rochester <strong>Institute</strong> of Technology<br />
Zachary Miknis<br />
Position: Gradu<strong>at</strong>e Student<br />
Educ<strong>at</strong>ion: B.S. in Biology and<br />
B.A. in Philosophy from the<br />
<strong>University</strong> of Scranton<br />
Danielle Simmons<br />
Position: Gradu<strong>at</strong>e Student<br />
Educ<strong>at</strong>ion: B.S. in Biology from<br />
St. Bonaventure <strong>University</strong><br />
Sanjay Connare<br />
Position: Research Aide<br />
Educ<strong>at</strong>ion: Working to complete<br />
a dual bachelor’s degree in<br />
economics and computer science<br />
<strong>at</strong> the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong><br />
Ann M. Wojtaszczyk<br />
Position: Student Intern<br />
Educ<strong>at</strong>ion: Currently a student <strong>at</strong><br />
Canisius College where she is<br />
studying biochemistry<br />
Lynn Nyazika<br />
Position: Research Aide<br />
Educ<strong>at</strong>ion: Studying pre-medicine<br />
and Chemistry, with a minor in<br />
Inform<strong>at</strong>ion Technology <strong>at</strong> D’Youville<br />
College<br />
Jimmitti Teysir<br />
Position: Student Intern<br />
Educ<strong>at</strong>ion: Currently a student <strong>at</strong><br />
City Honors High School<br />
RESEARCH AIDES AND INTERNS<br />
Amy L. DeLuca<br />
Position: Student Intern<br />
Educ<strong>at</strong>ion: Currently a student <strong>at</strong><br />
Canisius College where she is<br />
studying chemistry
ADMINISTRATION COMPUTER SYSTEMS DEVELOPMENT FINANCIAL MANAGEMENT GRAPHIC DESIGN PUBLIC RELATIONS AND GOVERNMENT AFFAIRS<br />
Jean Gallmeyer<br />
Position: Senior Administr<strong>at</strong>ive<br />
Assistant<br />
Darlene Miller<br />
Position: Facilities Aide<br />
Raymond M. Nagel<br />
Position: Software Developer<br />
Educ<strong>at</strong>ion: B.S. in Computer<br />
Inform<strong>at</strong>ion Systems from <strong>Buffalo</strong><br />
St<strong>at</strong>e College<br />
Dorothy Grimes<br />
Position: Administr<strong>at</strong>ive Assistant<br />
Educ<strong>at</strong>ion: A.O.S. in Administr<strong>at</strong>ive &<br />
Legal Assistance from Bryant and Str<strong>at</strong>ton<br />
Daniel P. Degnan<br />
Position: Director of Inform<strong>at</strong>ion Technology<br />
Educ<strong>at</strong>ion: B.S. in Medical Technology<br />
from the <strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>. He is also<br />
certified as an MCSE, MCP, A+ and is a<br />
Licensed Clinical Labor<strong>at</strong>ory Technologist<br />
Stephen A. Potter<br />
Position: Computer Systems Manager<br />
Educ<strong>at</strong>ion: B.S. in Physics from the<br />
<strong>University</strong> <strong>at</strong> <strong>Buffalo</strong><br />
Deanna Hefner<br />
Position: Human Resource Manager<br />
Educ<strong>at</strong>ion: A.A.S. in Medical Office<br />
Assistant from Erie Community<br />
College<br />
Geoffrey Franks<br />
Position: Systems Administr<strong>at</strong>or<br />
Educ<strong>at</strong>ion: B.S. in Applied Networking<br />
and Systems Administr<strong>at</strong>ion from<br />
the Rochester <strong>Institute</strong> of Technology<br />
Max Thayer<br />
Position: Software Developer<br />
Educ<strong>at</strong>ion: B.S. in Computer Inform<strong>at</strong>ion<br />
Systems from <strong>Buffalo</strong> St<strong>at</strong>e<br />
College, A.S. in Applied Science<br />
in Computer Systems from Alfred<br />
St<strong>at</strong>e College of Technology<br />
Laurie Elliott Krajna<br />
Position: Capital Campaign Manager<br />
Educ<strong>at</strong>ion: B.S. in Business Economics<br />
from College of Wooster<br />
Anne Kent<br />
Position: Controller<br />
Educ<strong>at</strong>ion: B.S. in Finance from<br />
<strong>Buffalo</strong> St<strong>at</strong>e College<br />
Gloria J. Del Bel<br />
Position: Principal Graphic Designer<br />
Educ<strong>at</strong>ion: B.F.A. in Printmaking<br />
from <strong>Buffalo</strong> St<strong>at</strong>e College and an<br />
A.A.S. in Graphic Design from<br />
Villa Maria College<br />
Lisa Foti Milk, CPA<br />
Position: Chief Financial Officer<br />
Educ<strong>at</strong>ion: B.S./B.A. in Accounting<br />
and Finance from the <strong>University</strong><br />
<strong>at</strong> <strong>Buffalo</strong><br />
Michael Logar<br />
Position: Assistant Controller<br />
Educ<strong>at</strong>ion: B.S. in Business Administr<strong>at</strong>ion,<br />
Accounting from <strong>Buffalo</strong> St<strong>at</strong>e<br />
College, A.A.S. in Business Administr<strong>at</strong>ion<br />
from Niagara County Community<br />
College<br />
Melda Tugac<br />
Position: Department Head,<br />
Graphic Design<br />
Educ<strong>at</strong>ion: B.A. in Liberal Arts<br />
from <strong>University</strong> of Istanbul, Turkey<br />
Michael Gurrea<br />
Position: Staff Accountant<br />
Educ<strong>at</strong>ion: Attending <strong>Buffalo</strong> St<strong>at</strong>e<br />
College for Business Administr<strong>at</strong>ion<br />
Melissa Couchman<br />
Position: Support Associ<strong>at</strong>e<br />
Educ<strong>at</strong>ion: B.S. in Business Administr<strong>at</strong>ion<br />
from Daemen College and<br />
an A.A.S. in Business Administr<strong>at</strong>ion<br />
from Erie Community College<br />
Tara A. Ellis<br />
Position: Director of Public Rel<strong>at</strong>ions<br />
Educ<strong>at</strong>ion: M.S. in Public Communic<strong>at</strong>ions<br />
from the S.I. Newhouse<br />
School <strong>at</strong> Syracuse <strong>University</strong>, B.A.<br />
in English Liter<strong>at</strong>ure from the<br />
<strong>University</strong> <strong>at</strong> <strong>Buffalo</strong>
CAPITAL CAMPAIGN DONORS DONOR HIGHLIGHTS<br />
In 2002, <strong>Hauptman</strong>-<strong>Woodward</strong>’s Board of Directors and Leadership Team recognized the<br />
need to modernize its facilities. The building <strong>at</strong> 73 High Street was no longer able to house<br />
the increasingly technologically advanced labs and equipment th<strong>at</strong> HWI needed to compete<br />
n<strong>at</strong>ionally and intern<strong>at</strong>ionally for scientific recruits and financial grants.<br />
A decision was made to build a new st<strong>at</strong>e-of-the-art biomedical research facility.<br />
The generosity of the donors listed below has made th<strong>at</strong> dream a reality. We would like to<br />
thank the following donors for supporting the capital campaign, The Cures Begin Here, <strong>at</strong><br />
<strong>Hauptman</strong>-<strong>Woodward</strong>:<br />
$14,000,000<br />
Empire St<strong>at</strong>e Development Corpor<strong>at</strong>ion<br />
$3,500,000<br />
John R. Oishei Found<strong>at</strong>ion<br />
$1,500,000<br />
The Margaret L. Wendt Found<strong>at</strong>ion<br />
$500,000 - $1,499,999<br />
James H. Cummings Found<strong>at</strong>ion, Inc.<br />
Constance W. Stafford Charitable Trust<br />
$200,000 - $499,999<br />
The Baird Found<strong>at</strong>ion<br />
Mr. William J. Constantine<br />
Grigg-Lewis Found<strong>at</strong>ion<br />
Richard W. and Mae Stone Goode Trust<br />
Mr. & Mrs. Paul J. Koessler<br />
$100,000 - $199,999<br />
Mr. & Mrs. Clement R. Arrison<br />
Cameron Baird Found<strong>at</strong>ion<br />
Community Found<strong>at</strong>ion for<br />
Gre<strong>at</strong>er <strong>Buffalo</strong><br />
Mr. & Mrs. Walter J. Constantine, Jr.<br />
The Children’s Guild<br />
Mrs. Whitworth Ferguson, Jr.,<br />
Ferguson Family Found<strong>at</strong>ion, Inc.,<br />
Ferguson Electric Found<strong>at</strong>ion<br />
Mr. & Mrs. Peter B. Flickinger,<br />
Mr. & Mrs. Thomas R. Flickinger,<br />
Mr. William S. Flickinger<br />
Mr. & Mrs. Donald Hess<br />
Pamela Jacobs Vogt and family<br />
Seymour H. Knox Found<strong>at</strong>ion<br />
M&T Charitable Found<strong>at</strong>ion<br />
William McGowan Charitable Trust<br />
Dr. & Mrs. Walter F. Stafford, III<br />
$50,000 - $99,999<br />
Mr. & Mrs. Charles E. Balbach<br />
Edward H. Butler Found<strong>at</strong>ion<br />
Peter Cornell Trust<br />
Adele and George DeTitta<br />
Jaeckle, Fleischmann & Mugel, LLP<br />
Moog, Inc.<br />
Phyllis W. Pierce Charitable Lead<br />
Annuity Trust<br />
Lawrence Quinn<br />
Mr. & Mrs. Robert Wilmers<br />
$20,000 - $49,999<br />
Mrs. Marjorie Buyers<br />
Mr. & Mrs. Frank Ciminelli<br />
Mr. John Cordes &<br />
Ms. Michele Heffernan<br />
Dr. and Mrs. Angelo M. F<strong>at</strong>ta<br />
First Niagara Bank Found<strong>at</strong>ion<br />
Freed, Maxick & B<strong>at</strong>taglia CPA’s PC<br />
Jane and Richard Griffin<br />
Mr. & Mrs. Thomas R. Hyde<br />
Mr. & Mrs. John A. Mitchell<br />
Verizon Found<strong>at</strong>ion<br />
Western New York Found<strong>at</strong>ion<br />
Mr. & Mrs. Gilbert Yager<br />
$10,000 - $19,999<br />
Dr. & Mrs. Richard A. Aubrecht<br />
Citizens Bank<br />
John W. Danforth Company<br />
Mr. & Mrs. Charles Dowdell<br />
Dr. Edith Flanigen<br />
Mr. & Mrs. Christopher T. Greene<br />
Josephine Goodyear Found<strong>at</strong>ion<br />
Sarah Goodyear<br />
Mr. & Mrs. Wilson Gre<strong>at</strong>b<strong>at</strong>ch<br />
Dr. & Mrs. David Hohn<br />
Dr. & Mrs. L. Nelson Hopkins, III<br />
Mrs. N. Jane Maroone<br />
The Pearce Family<br />
Rotary Found<strong>at</strong>ion of <strong>Buffalo</strong><br />
Mr. & Mrs. Douglas G. Swift<br />
Mr. & Mrs. John M. Wadsworth<br />
$5,000 - $9,999<br />
Mr. & Mrs. Henry H. Baxter<br />
Mr. & Mrs. Thomas R. Beecher, Jr.<br />
Mr. & Mrs. Norbert A. Bennett<br />
Mr. & Mrs. James R. Biltekoff<br />
Mr. & Mrs. Jerry Castiglia<br />
Frances G. Churchill Fund<br />
Walsh Duffield Companies, Inc.<br />
Mr. Finley R. Greene, Jr.<br />
Mr. & Mrs. Donald J. Holzman<br />
Mr. William N. Hudson, Jr.<br />
Mr. & Mrs. Theodore E. Marks<br />
McGard, Inc.<br />
Dr. & Mrs. Peter Ostrow<br />
Dr. & Mrs. Walter Pangborn<br />
Mr. & Mrs. Theodore Rich<br />
Mr. & Mrs. Robert E. Sadler, Jr.<br />
Mr. Richard Shaughnessy<br />
Mr. & Mrs. Brian Townson<br />
VIYU Found<strong>at</strong>ion<br />
$1,000 - $4,999<br />
Mrs. C. Angela Bontempo<br />
Dr. Vivian Cody<br />
Mr. & Mrs. Richard W. Cutting<br />
Mrs. Erika Daley<br />
Mr. & Mrs. James Degen<br />
DeSpirt Mosaic & Marble Co., Inc<br />
Donald Davis Found<strong>at</strong>ion<br />
Mr. & Mrs. Fred Friedman<br />
Mr. & Mrs. Richard E. Garman<br />
Dr. & Mrs. Herbert A. <strong>Hauptman</strong><br />
Invitrogen Corpor<strong>at</strong>ion<br />
Kaleida Health<br />
Mr. & Mrs. Bernard J. Kennedy<br />
Mrs. Mary M. Koessler<br />
Mr. & Mrs. Anthony B. Martino<br />
The Messer Found<strong>at</strong>ion<br />
Mrs. Lisa Foti Milk<br />
Mr. Kenneth F. Myszka<br />
Dr. & Mrs. Yoshio Osawa<br />
Mr. & Mrs. William J. Regan, Jr.<br />
Mr. & Mrs. Emmett L. Reilly<br />
Mr. & Mrs. Kevin G. Reilly<br />
Mr. & Mrs. P<strong>at</strong>rick Reilly<br />
Mrs. Lois F. Renz<br />
Sevenson Environmental Services<br />
Mrs. Constance S. Umland<br />
Mr. Richard R. Upton<br />
LIFE MEMBERS<br />
Mrs. Gilbert J. Yager<br />
We would like to thank and acknowledge the following donors to <strong>Hauptman</strong>-<strong>Woodward</strong>,<br />
making a gift in our fiscal year <strong>2006</strong>. (November 1, 2005 – October 31, <strong>2006</strong>)<br />
$250,000+<br />
The Est<strong>at</strong>e of Jackson C<strong>at</strong>t<br />
James H. Cummings Found<strong>at</strong>ion<br />
$100,000<br />
The Grigg-Lewis Found<strong>at</strong>ion<br />
$50,000 - $99,999<br />
Mr. & Mrs. Clement R. Arrison<br />
Arthritis Found<strong>at</strong>ion<br />
The Baird Found<strong>at</strong>ion<br />
The Cameron Baird Found<strong>at</strong>ion<br />
The Children’s Guild<br />
Mr. William J. Constantine<br />
Richard & Mae Stone Goode Trust<br />
The family of Dr. Lawrence Jacobs<br />
Key Found<strong>at</strong>ion<br />
Seymour H. Knox Found<strong>at</strong>ion<br />
Constance W. Stafford Charitable Trust<br />
Margaret L. Wendt Found<strong>at</strong>ion<br />
Mr. & Mrs. Robert Wilmers<br />
$25,000 - $49,999<br />
<strong>Buffalo</strong> Medical Group<br />
Mr. & Mrs. Thomas R. Hyde<br />
Mr. & Mrs. Paul J. Koessler<br />
M&T Charitable Found<strong>at</strong>ion<br />
$10,000 - $24,999<br />
Mr. & Mrs. Charles E. Balbach<br />
Edward H. Butler Found<strong>at</strong>ion<br />
Mr. John Cordes & Ms. Michele Heffernan<br />
The Community Found<strong>at</strong>ion for Gre<strong>at</strong>er <strong>Buffalo</strong><br />
Mr. & Mrs. Donald Hess<br />
Josephine Goodyear Found<strong>at</strong>ion<br />
Kaleida Health<br />
Moog, Inc.<br />
Mrs. N. Jane Maroone<br />
Mrs. Joseph Stewart<br />
Verizon Found<strong>at</strong>ion<br />
PARTNER’S IN RESEARCH<br />
$5,000 - $9,999<br />
Dr. and Mrs. Richard A. Aubrecht<br />
Mr. & Mrs. Jerry Castiglia<br />
Citizens Bank<br />
Mr. and Mrs. Walter Constantine, Jr.<br />
Adele and George DeTitta<br />
Dr. and Mrs. Angelo M. F<strong>at</strong>ta<br />
Mrs. Whitworth Ferguson, Jr.<br />
Ferguson Electric Found<strong>at</strong>ion<br />
Ferguson Family Found<strong>at</strong>ion, Inc.<br />
Ms. Edith M. Flanigen<br />
Frances G. Churchill Fund<br />
Jane and Richard Griffin<br />
Key Bank<br />
Mr. and Mrs. Vincent Lawless<br />
Little-Kittinger Found<strong>at</strong>ion<br />
Louis S. & Molly B. Wolk Found<strong>at</strong>ion<br />
McDonald Financial Group<br />
Mr. and Mrs. John A. Mitchell<br />
NYS Center of Excellence<br />
Praxair, Inc.<br />
Research Found<strong>at</strong>ion of SUNY<br />
Mr. and Mrs. Theodore Rich<br />
Scott, Danahy & Naylon Co., Inc.<br />
Dr. and Mrs. Walter F. Stafford, III<br />
Mr. and Mrs. Douglas G. Swift<br />
United Way of <strong>Buffalo</strong> & Erie County<br />
VIYU Found<strong>at</strong>ion<br />
DIAMOND CIRCLE MEMBERS<br />
$2,500 - $4,999<br />
Mr. and Mrs. Norbert A. Bennett<br />
Mrs. Marjorie Buyers<br />
Mr. and Mrs. Christopher T. Greene<br />
Dr. and Mrs. David C. Hohn<br />
Jaeckle, Fleischmann & Mugel, LLP<br />
John W. Danforth Company Found<strong>at</strong>ion, Inc.<br />
Mr. & Mrs. Bernard J. Kennedy<br />
Mr. and Mrs. G. David Koepf<br />
Lifetime Health<br />
Mr. and Mrs. Robert L. Montgomery, Jr.<br />
Dr. and Mrs. Walter A. Pangborn<br />
Roswell Park Cancer <strong>Institute</strong><br />
U&S Services<br />
Walsh Duffield Companies, Inc.<br />
CRYSTAL CIRCLE MEMBERS<br />
$1,500 - $2,499<br />
Berger & Berger<br />
Mr. and Mrs. James R. Biltekoff<br />
Bristol-Myers Squibb Found<strong>at</strong>ion, Inc.<br />
<strong>Buffalo</strong> Museum of Science<br />
<strong>Buffalo</strong> Niagara Medical Campus<br />
Mr. and Mrs. Gary M. Burger<br />
Mr. and Mrs. Bruce Buyers<br />
Computer Task Group, Inc.<br />
Damon & Morey LLP<br />
Mrs. Cynthia Doolittle<br />
Dr. and Mrs. William L. Duax<br />
Mr. and Mrs. Thomas R. Flickinger<br />
Freed, Maxick & B<strong>at</strong>taglia CPA's PC<br />
Mr. and Mrs. Richard E. Garman<br />
Irenaeus Found<strong>at</strong>ion<br />
Key Bank<br />
Dr. and Mrs. Yoshio Osawa<br />
Pearce Family<br />
Peter & Elizabeth C. Tower Found<strong>at</strong>ion<br />
Savarino Companies<br />
Sevenson Environmental Services<br />
SUNY Health Sciences<br />
UB STOR<br />
CIRCLE PATRONS<br />
$1,000 - $1,499<br />
Mr. and Mrs. Thomas R. Beecher, Jr.<br />
Mr. and Mrs. Maxwell Caulkins<br />
Mr. and Mrs. Richard W. Cutting<br />
Mr. and Mrs. James Degen<br />
Mr. and Mrs. Thomas C. Detwiler<br />
Mrs. Jeanne C. E<strong>at</strong>on<br />
Ellicott Development Company<br />
Mrs. Marion Flemming<br />
Mr. and Mrs. Fred Friedman<br />
Mrs. Anne L. Gardner<br />
Mr. and Mrs. Robert J. A. Irwin<br />
Ms. Lucetta C. Knox<br />
Mrs. Mary M. Koessler<br />
Dr. K<strong>at</strong>hleen Kreis<br />
Mr. Norman E. Mack, II<br />
Mr. and Mrs. Jeffrey B. Marsh<br />
Mr. and Mrs. Anthony B. Martino<br />
Mr. and Mrs. E. Dennis McCarthy<br />
Mr. & Mrs. Lewis McCauley<br />
Mr. and Mrs. Donald M. McClellan<br />
Mrs. Lisa Foti Milk<br />
Mills Welding Supply<br />
Mr. and Mrs. William J. Regan, Jr.<br />
Research Facilities Design<br />
Rigaku-MSC<br />
Rigidized Metals<br />
Mr. Richard W. Shaughnessy<br />
Souter Productions Inc<br />
Mr. and Mrs. Reid W. Stafford<br />
Mrs. Richard W. Stewart<br />
The <strong>Buffalo</strong> News<br />
UBS Found<strong>at</strong>ion USA M<strong>at</strong>ching Gift Program<br />
Mr. Richard R. Upton<br />
Mr. and Mrs. Samuel F. Ward<br />
CIRCLE SPONSORS<br />
$500- $999<br />
Mr. and Mrs. Charles Lee Abell<br />
Mr. and Mrs. Douglas T. Baker<br />
Mr. and Mrs. Henry H. Baxter, P.E.<br />
Dr. and Mrs. Theodore S. Bistany<br />
Mr. and Mrs. Michael A. Brady<br />
Mr. and Mrs. Theodore Chertoff<br />
DeSpirt Mosaic & Marble Co., Inc.<br />
Mr. and Mrs. Alan L. Dressler<br />
Dr. Edward G. Eberl<br />
Dr. Eugene L. Gaier<br />
Dr. Robert J. Genco<br />
Mr. and Mrs. Christopher Gibas<br />
Mr. Thomas More Griffin<br />
Dr. Kenneth W. Gross<br />
Mr. Charles J. Hahn<br />
Dr. Barbara Henderson<br />
Mr. and Mrs. Chris Henderson<br />
Dr. and Mrs. L. Nelson Hopkins, III<br />
Mr. John T. Hoskins<br />
HSBC M<strong>at</strong>ching Gift Program<br />
Mr. and Mrs. Hartley Frank Hutchins<br />
Johnson & Johnson<br />
Mr. and Mrs. William L. Joyce<br />
Drs. James R. Kanski<br />
Honorable and Mrs. Theodore S. Kasler<br />
Mr. and Mrs. Charles F. Kreiner, Sr.<br />
Drs. Susan Graham & Jon C. Kucera<br />
Dr. and Mrs. Paul Kurtz<br />
Mr. and Mrs. Anthony M Masiello<br />
Dr. and Mrs. J. Arthur M<strong>at</strong>tern<br />
Mr. and Mrs. Richard Minekime<br />
Dr. and Mrs. Herman S. Mogavero, Jr.<br />
Niagara Aerospace Museum<br />
Dr. and Mrs. Peter T. Ostrow<br />
Miss Frances M. Rew<br />
Mr. and Mrs. Edward B. Righter<br />
Rotary Club of <strong>Buffalo</strong><br />
Mr. and Mrs. John G Stanley, Jr.<br />
The Floristry
DONOR HIGHLIGHTS<br />
CIRCLE SPONSORS<br />
$500 - $999<br />
Mr. and Mrs. James M. Wadsworth<br />
Mr. William Wadsworth<br />
Mr. Arthur J. Ziffer<br />
Mr. and Mrs. C. Richard Zobel<br />
CIRCLE MEMBERS<br />
$250 - $499<br />
Accumed Technologies Inc.<br />
Mr. and Mrs. C. Teo Balbach<br />
Mrs. Wavel H. Barber<br />
Mrs. Janice C. Boneberg<br />
BuffLink, Inc.<br />
Mr. and Mrs. Robert M. Butcher<br />
Dr. and Mrs. T. Ming Chu<br />
Dr. Vivian Cody<br />
Mrs. William J. Conners, III<br />
Mr. and Mrs. John R. Connolly<br />
Mr. and Mrs. Arthur W. Cryer<br />
Mr. and Mrs. Thomas H. Danforth<br />
Mr. and Mrs. Michael Day<br />
Dr. and Mrs. Peter C. Dow<br />
Ms. Jennifer Dowdell<br />
Dr. and Mrs. Edmund Egan<br />
Mr. and Mrs. Stephen R. Foley<br />
Garrett Le<strong>at</strong>her Corpor<strong>at</strong>ion<br />
Mr. Finley R. Greene, Jr.<br />
Dr. and Mrs. Bruce <strong>Hauptman</strong><br />
Mrs. Ann Holland Cohn<br />
Mrs. L. Nelson Hopkins, Jr.<br />
HP Employee Charitable Giving Program<br />
Mr. and Mrs. William Baird Irwin<br />
Dr. and Mrs. Herbert E. Joyce<br />
Dr. and Mrs. Kenneth R. Kahn<br />
Dr. Chari Briggs & Mr. Joel Krenis<br />
Mr. and Mrs. Robert J. Kresse<br />
Louis P. Ciminelli Construction Co., Inc.<br />
Marks Family Found<strong>at</strong>ion<br />
Mrs. Walter J. M<strong>at</strong>t<br />
Mr. and Mrs. Arnold Maxick<br />
Mr. and Mrs. Richard E. McGill<br />
Mr. and Mrs. Clarke H. Narins<br />
Mr. and Mrs. Reginald B. Newman, II<br />
Drs. Dean & Donna Orman<br />
Ms. Michelle Pangborn<br />
Dr. and Mrs. John H. Peterson<br />
Mr. Richard S. Piccoli<br />
Ms. Wendy Pierce<br />
Mrs. Marjorie M. Plumb<br />
Mr. and Mrs. P<strong>at</strong>rick Reilly<br />
Dr. and Mrs. Peter Schaber<br />
Mr. and Mrs. C. Jacob Schneider<br />
Mr. and Mrs. James R. Spengler, Jr.<br />
The Premier Group Member Wine Stores<br />
Dr. and Mrs. James F. Upson<br />
Mr. and Mrs. Hugh M. Van Alstyne<br />
Mrs. Nancy S. Warner<br />
W<strong>at</strong>son, Bennett, Colligan, Johnson &<br />
Schechter LLP<br />
Mr. and Mrs. Wayne D. Wisbaum<br />
WomenStories<br />
SUPPORTERS<br />
$100 - $249<br />
Dr. and Mrs. Mark W. Ackley<br />
Mr. and Mrs. Robert J. Adams<br />
Mr. and Mrs. J. Keith Alford<br />
Ms. Anne Allan<br />
Mr. and Mrs. Stephen C. Ames<br />
Mr. and Mrs. Gordon P. Assad<br />
Mr. Herbert A. Aurbach<br />
Mr. and Mrs. Virgil J. Austin<br />
Dr. and Mrs. Allen Barnett<br />
Mr. and Mrs. Rudolf L. Bauer<br />
Dr. and Mrs. Robert A. Baumler<br />
Ms. Ellen W. Baxter<br />
Mrs. Sharon R. Bouvier<br />
Mr. Brian P. Brady<br />
Mr. and Mrs. Thomas H. Brown<br />
Ms. Audre Bunis<br />
Ms. Martha Burke<br />
Mr. Leroy G. Callahan<br />
Dr. and Mrs. Chun-Shi Chang<br />
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RECENT PUBLICATIONS<br />
• Brucz K, Miknis ZJ, Schultz LW, Umland TC. Expression, purific<strong>at</strong>ion and characteriz<strong>at</strong>ion of recombinant severe acute respir<strong>at</strong>ory syndrome<br />
coronavirus non-structural protein 1. Protein Expr Purif. <strong>2006</strong> Nov 14; [Epub ahead of print]<br />
• Cody V, Davis PJ, Davis FB. Molecular modeling of the thyroid hormone interactions with alphavbeta3 integrin. Steroids. <strong>2006</strong> Dec 11;<br />
[Epub ahead of print]<br />
• Cody, V. (2005). Thyroid Hormone Structure-Function Rel<strong>at</strong>ionships. In Werner and Ingbar's The Thyroid: A Fundamental and Clinical Text,<br />
9th edition, Braverman, L. E. & Utiger, R. D. (eds), Lippincott Williams & Wilkins Publishers, Philadel phia, pp. 151-157.<br />
• Cody V, Pace J, Chisum K, Rosowsky A. New insights into DHFR interactions: analysis of Pneumocystis carinii and mouse DHFR complexes<br />
with NADPH and two highly potent 5-(omega-carboxy(alkyloxy) trimethoprim deriv<strong>at</strong>ives reveals conform<strong>at</strong>ional correl<strong>at</strong>ions with activity and<br />
novel parallel ring stacking interactions. Proteins. <strong>2006</strong> Dec1;65(4):959-69.<br />
• Bosch J, Robien MA, Mehlin C, Boni E, Riechers A, Buckner FS, Van Voorhis WC, Myler PJ, Worthey EA, DeTitta G, Luft JR, Lauricella A,<br />
Gulde S, Anderson LA, Kalyuzhniy O, Neely HM, Ross J, Earnest TN, Soltis M, Schoenfeld L, Zucker F, Merritt EA, Fan E, Verlinde CL, Hol WG.<br />
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J Med Chem.<br />
<strong>2006</strong> Oct 5;49(20):5939-46.<br />
• Ericsson UB, Hallberg BM, DeTitta GT, Dekker N, Nordlund P. Thermofluor-based high-throughput stability optimiz<strong>at</strong>ion of proteins for<br />
structural studies. Anal Biochem. <strong>2006</strong> Oct 15;357(2):289-98<br />
• Immormino RM, Kang Y, Chiosis G, Gewirth DT. Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors.<br />
J Med Chem. <strong>2006</strong> Aug 10;49(16):4953-60.<br />
• Xu H, <strong>Hauptman</strong> HA. Recent advances in direct phasing methods for heavy-<strong>at</strong>om substructure determin<strong>at</strong>ion. Acta Crystallogr D Biol<br />
Crystallogr. <strong>2006</strong> Aug;62(Pt 8):897-900.<br />
• Pletnev VZ, Thomas JL, Rhaney FL, Holt LS, Scaccia LA, Umland TC and Duax WL. R<strong>at</strong>ional Proteomics V: Structure-based mutagenesis has<br />
revealed key residues responsible for substr<strong>at</strong>e recognition and c<strong>at</strong>alysis by the dehydrogenase and isomerase activities in human 3betahydroxysteroid<br />
dehydrogenase/isomerase type 1. J. Steroid.Biochem Mol Biol. <strong>2006</strong> Sep; 101(1): 50-60.<br />
• Williams AH, Immormino RM, Gewirth DT, Raetz CR. Structure of UDP-N-acetylglucosamine acyltransferase with a bound antibacterial<br />
pentadecapeptide. Proc N<strong>at</strong>l Acad Sci U S A. <strong>2006</strong> Jul 18;103(29):10877-82.<br />
• Sundlov JA, Garringer JA, Carney JM, Reger AS, Drake EJ, Duax WL, Gulick AM. Determin<strong>at</strong>ion of the crystal structure of EntA, a 2,3dihydro-2,3-dihydroxybenzoic<br />
acid dehydrogenase from Escherichia coli. Acta Crystallogr D Biol Crystallogr. <strong>2006</strong> Jul;62(Pt 7):734-40.<br />
• Snell EH, van der Woerd MJ, Damon M, Judge RA, Myles DA, Meilleur F. Optimizing crystal volume for neutron diffraction: D: -xylose<br />
isomerase. Eur Biophys J. <strong>2006</strong> May 25.<br />
• Holmes MA, Buckner FS, Van Voorhis WC, Verlinde CL, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Zucker F,<br />
Schoenfeld LW, Earnest TN, Hol WG, Merritt EA. Structure of ribose 5-phosph<strong>at</strong>e isomerase from Plasmodium falciparum. Acta Crystallograph<br />
Sect F Struct Biol Cryst Commun. <strong>2006</strong> May 1;62(Pt 5):427-31.<br />
• He H, Z<strong>at</strong>orska D, Kim J, Aguirre J, Llauger L, She Y, Wu N, Immormino RM, Gewirth DT, Chiosis G. Identific<strong>at</strong>ion of potent w<strong>at</strong>er soluble<br />
purine-scaffold inhibitors of the he<strong>at</strong> shock protein 90. J Med Chem. <strong>2006</strong> Jan 12;49(1):381-90.<br />
• Meilleur F, Snell EH, van der Woerd MJ, Judge RA, Myles DA. A quasi-Laue neutron crystallographic study of D-xylose isomerase. Eur<br />
Biophys J. <strong>2006</strong> May 4.<br />
• Drake EJ, Nicolai DA, Gulick AM. Structure of the EntB multidomain nonribosomal peptide synthetase and functional analysis of its interaction<br />
with the EntE adenyl<strong>at</strong>ion domain. Chem Biol. <strong>2006</strong> Apr;13(4):409-19.<br />
• Holmes MA, Buckner FS, Van Voorhis WC, Mehlin C, Boni E, Earnest TN, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Zucker F,<br />
Schoenfeld LW, Hol WG, Merritt EA. Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum. Acta<br />
Crystallograph Sect F Struct Biol Cryst Commun. <strong>2006</strong> Mar 1;62(Pt 3):180-5.<br />
• Arakaki T, Le Trong I, Phizicky E, Quartley E, DeTitta G, Luft J, Lauricella A, Anderson L, Kalyuzhniy O, Worthey E, Myler PJ, Kim D, Baker D,<br />
Hol WG, Merritt EA. Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major. Acta Crystallograph Sect F Struct Biol<br />
Cryst Commun. <strong>2006</strong> Mar 1;62(Pt 3):175-9.<br />
• Robien MA, Bosch J, Buckner FS, Van Voorhis WC, Worthey EA, Myler P, Mehlin C, Boni EE, Kalyuzhniy O, Anderson L, Lauricella A, Gulde<br />
S, Luft JR, DeTitta G, Caruthers JM, Hodgson KO, Soltis M, Zucker F, Verlinde CL, Merritt EA, Schoenfeld LW, Hol WG. Crystal structure of<br />
glyceraldehyde-3-phosph<strong>at</strong>e dehydrogenase from Plasmodium falciparum <strong>at</strong> 2.25 A resolution reveals intriguing extra electron density in the<br />
active site. Proteins. <strong>2006</strong> Mar 15;62(3):570-7.<br />
• Caruthers J, Bosch J, Buckner F, Van Voorhis W, Myler P, Worthey E, Mehlin C, Boni E, DeTitta G, Luft J, Lauricella A, Kalyuzhniy O, Anderson<br />
L, Zucker F, Soltis M, Hol WG. Structure of a ribulose 5-phosph<strong>at</strong>e 3-epimerase from Plasmodium falciparum. Proteins. <strong>2006</strong> Feb<br />
1;62(2):338-42.