2009 DOM Annual Report - Department of Medicine - University of ...

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Department of Medicinecellular survival proteins that are overexpressed in human head and neck cancers. They determined that targeting these survival proteins led torapid death of head and neck cancer cells that are highly resistant to chemotherapy, suggesting a novel strategy for treatment of patients withthis malignancy, as well as other forms of cancer that are chemotherapy resistant.Dr. Ramalingam and colleagues performed a Phase I trial with a histone deacetylase inhibitor, vorinostat, in combination with chemotherapy andobserved a clinical response rate that was substantially greater than that expected with the chemotherapy drugs alone. Based on these results,NCI-sponsored Phase II studies of this combination will be performed by the Division in patients with melanoma, lung or ovarian carcinomas.Additional preclinical and clinical studies of other histone deacetylase inhibitors in combination are also in progress as epigenetic aspects ofmalignancy are becoming a new focus within the Division (Clin Cancer Res. 2007 Jun 15;13(12):3605-10).Dr. Brufsky and colleagues addressed osteoporosis associated with treatment with an aromatase inhibitor, which is a major problem associatedwith such therapy in postmenopausal women with breast cancer, and demonstrated that zolendronic acid substantially inhibited bone loss.These results indicate that zolendronic acid should serve as an important adjunct to breast cancer treatment by an aromatase inhibitor (J ClinOncol 25(7): 829-836, 2007).SELECTED SCHOLARLY ACTIVITIESStudy sections (excluding ad hoc review), editorial boards, and other honorsMajor HonorsG. David Roodman, Elected Chairman for the Paget Foundation in 2006 and received Louis V. Avioli Founders Award for Basic Research in Bone,2007Grant Reviewers for NIHAthanassios Argiris, External reviewer for CTEP (Cancer Therapy Evaluation Program) at the NCI (National Cancer Institute) for Phase III Studies,2005-PresentPreet M. Chaudhary, Charter member, Developmental Therapeutics Study section, 2006-presentDaniel E. Johnson, Standing member for NIH/NCI Study Section (“Drug Discovery and Molecular Pharmacology”)John M. Kirkwood, HJ Lloyd Trust Research Review Section, 2003-presentJoseph E. Kiss, Co-chair NHLBI Transfusion Medicine & Hemostasis TTP subcommitteeKenneth Scott McCarty, Department of Defense Breast Cancer Research Program TRN-6 panelMargaret V. Ragni, Am. Soc. Hematology (ASH) Study Section, Clinical Research Training Institute (CRTI), 2005-2007; Member, NHLBI Hemostasisand Thrombosis (HT) Study Section, NIH, 2007-2011, Steering Committee, Hemophilia Subcommittee, Transfusion Med Clinical Trials Network(NHLBI)38 Better medicine through research and education.
2007Robert L. Redner, Leukemia, Immunology and Blood Disease (LIB) Study Section, American Cancer SocietyG. David Roodman, SRA, Skeletal Biology Structure & Regeneration Study Section, 2005-presentEditorial boardsAthanassios Argiris, Journal of Clinical Oncology, International Journal of Cancer ResearchLisa H. Butterfield, Associate Editor, Cancer Research, and Associate Editor, The Journal of ImmunologyPreet M. Chaudhary, Cancer Biology and Therapy, International Archive of Bioscience, Experimental Biology and MedicineAlbert Donnenberg, Clinical and Applied Immunology Reviews (CAIR), Editor, CRC Handbook of Clinical Immunology, 2nd Edition, CRC Press, BocaRaton, FLMerrill J. Egorin, Editor-in-Chief, Cancer Chemotherapy and Pharmacology; Clinical Cancer Research, Clinical Pharmacology and Therapeutics;Cancer Therapeutics; Journal of National Cancer Institute; Current Clinical Pharmacology, Journal of Experimental Biology and Medicine, Field Editor,Fundamental and Clinical Pharmacology; International Journal of Clinical OncologyKenneth A. Foon, Clinical Cancer Research, Associate Editor; Journal of Experimental Biology and Medicine, Editor, Translational Research SectionExpert Opinion on Biological Therapy, Co-Editor, Future PerspectivesDaniel E. Johnson, Section Editor, LeukemiaMarkus Mapara, Associate Editor Journal of ImmunologyMonica C. Panelli, Associate Editor Journal of Translational MedicineMargaret V. Ragni, ASH Daily News: Writer for American Society Hematology (ASH) Annual Meeting, 2006; Editor, ASH Daily News: Edit theAmerican Society Hematology (ASH) Annual Meeting publication, 2007.G. David Roodman, Experimental Hematology, Bone , Journal of Clinical Investigation, and Endocrinology, Associate Editor, Journal of Bone andMineral Research, Experimental Biology and MedicineAhmad Tarhini, Cancer Chemotherapy and PharmacologyVictor G. Vogel, Breast Diseases (Mosby), Oncology, Cancer Updates, Research, and Education (CURE), The Breast Journal, Associate Editor, Journalof Clinical OncologyOtherAthanassios Argiris, Advisory Committee Membership: Eastern Cooperative Oncology Group (ECOG) Head and Neck Core Committee Member,2001-present; Eastern Cooperative Oncology Group (ECOG) Thoracic Core Committee Member, 2002-present; Head and Neck Intergroupmeeting participant, ECOG Developmental Therapeutic CommitteeAnthony G. Brickner, 2004 ASH Celgene Scholar, The American Society of Hematology Clinical/Translational Research Junior Faculty ScholarAward (recipient of one of six Junior Faculty Scholar Awards awarded), 2004,2005,2006Adam Brufsky, America’s Top Doctors, Castle Connolly Corporation, 2005, 2006, 2007; America’s Top Doctors for Cancer, Castle ConnollyCorporation 2005, 2006Frank S. Lieberman, Subcommittee for Board Examination Development, Neurooncology Subspecialty Board, American Academy of NeurologyMargaret V. Ragni, Executive Board, Hemophilia Research Society North America, Nomination, Chair, National Hemophilia Foundation (NHF)Medical & Scientific & Advisory Committee (MASAC), 2006Priya Rastogi, NSABP, Associate Director for Medical Affairs, NSABP, Vice Chair for Medical AffairsRobert L. Redner, Advisory Committee Membership: American Society of Hematology TMDC Committee (to develop an in-service examinationfor Hematology Fellowships)G. David Roodman, Medical Advisory Committee – The Leukemia & Lymphoma Society,Victor G. Vogel, Advisory Committee Membership: Board of Directors, National Surgical Adjuvant Breast and Bowel Project; PreventionCommittee, American Society of Clinical Oncology (ASCO); Education Committee, American Society of Clinical Oncology (ASCO)39
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