2009 DOM Annual Report - Department of Medicine - University of ...

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Department of MedicineDr. Bruns, Kleyman and colleagues published a manuscript in J Biol Chem (282:6153-60, 2007) demonstrating that multiple proteases need tocleave the gamma subunit of the epithelial sodium channel (ENaC) to fully activate the channel. Channel activation is due to the release of aninhibitory domain. They proposed that multiple proteolytic cleavage events, including cleavage of the alpha and gamma subunits, lead to astepwise activation of ENaC, reflected in a graded increase in channel open probability.Dr. Weixel, Kleyman and colleagues have a manuscript in press in J Biol Chem that demonstrates regulation of cell surface ENaC expression by anapically localized isoform of phosphatidylinositol 5-kinase (PI5K). Their data suggest that a PI5K-mediated increase in PIP2 levels downregulatesENaC activity via an increase in epsin-dependent endocytosis of the channel.SELECTED SCHOLARLY ACTIVITIESStudy sections (excluding ad hoc review), editorial boards, and other honorsMajor HonorsGerard Apodaca, MERIT Award, National Institutes of HealthLori A. Birder, MERIT Award, National Institutes of HealthThomas R. Kleyman, Recipient of MERIT Award from the NIHGrant ReviewGerard Apodaca, American Heart Association Cell Biology Study Section, ACS Cell Structure and Metastasis Study SectionMary Choi, American Heart Association, National Center, Cardiorenal Study Section, American Society of Nephrology Grant Review54 Better medicine through research and education.
2007Kenneth Hallows, The Wellcome Trust, Programme Grant Reviewer (three times)Thomas R. Kleyman, Regular Member, Cellular and Molecular Biology of the Kidney Study Section, NIH, NIDDK, T35 Training Grants, NIDDK, CFCenters, Research Committee, American Heart Association, National CenterOra A. Weisz, American Heart Association Study Section (Mid-Atlantic affiliate)Editorial BoardsGerard Apodaca, Associate Editor, American Journal of Physiology, Renal Physiology, American Journal of Physiology, Cellular Physiology, TrafficLori A. Birder, American Journal of Physiology, Neurourology and Urodynamics, and PharmacologyOnLine.itLinda F. Fried, Journal American Society of NephrologyKenneth Hallows, American Journal of Physiology: Renal PhysiologyRebecca P. Hughey, American Journal of Physiology: Renal PhysiologyJohn P. Johnson, American Journal of Physiology: Renal PhysiologyThomas R. Kleyman, Editor-in-Chief, American Journal of Physiology: Renal Physiology 2007; Journal of Biological Chemistry, the Journal of ClinicalInvestigation, and the Scientific World JournalPaul M. Palevsky, Associate Editor, NephSAP, Associate Editor (Acute Renal Failure), Clinical Journal of the American Society of Nephrology, Journalof Intensive Care Medicine, ACCP-SEEK (Critical Care Medicine), UpToDate (Section Editor: Renal Failure)Beth M. Piraino, Peritoneal Dialysis International, Seminars in Dialysis, The kidney.org, Editor of the Peritoneal Dialysis Section, CJASN, 2005-present, American J Kidney Disease,Ora A. Weisz, American Journal of Physiology, Renal, American Journal of Physiology, Cell Physiology,OtherLori A. Birder, Secretary/Treasurer, ASPET Division Systems/Integrative Pharmacology, Chair, Neural Control Committee, 4th World HealthOrganization International Consultation on Incontinence, ParisMary Choi, American Journal of Physiology-Renal PhysiologyKenneth Hallows, American Society of Nephrology, Abstract Review Category Chairperson, Nephrology Faculty, Faculty of 1000 MedicineJames R. Johnston, Best Docs in Pittsburgh, Pittsburgh magazine, May 2007, Recognized by Castle Connolly as one of America’s Top Doctors,May 2007 Member, Executive Council for Training Program Directors of the American Society of Nephrology (elected), Chairman, Subcommitteefor Future Recommendations to the Residency Review Committee for the Training program directors of the ASNThomas R. Kleyman, Research Representative, American Heart Association, Council on the Kidney in Cardiovascular Disease LeadershipCommitteePaul M. Palevsky, Member ASN Acute Kidney Injury Advisory Group, ESRD Network 4 Member, Network Coordinating Council, 1989-present,Forum of ESRD Networks, Member, Board of Directors, Co-Chairman, Anemia Workgroup, 2007Beth M. Piraino, Co-chair of the Spring Meetings Planning Committee, NKF, Chair Guidelines Committee of the ISPD, Secretary and now VicePresident of the NKF of the Alleghenies, Best Doctors in America, 2006 and 2007, Pittsburgh magazine as Best Doctor in Renal, 2007Ora A. Weisz, Symposium Organizer, The Physiological Society Main Meeting, London, England, Abstract Review Chair, Cell and TransportPhysiology: Protein Sorting/Epithelial Polarity section, American Society of Nephrology Annual Meeting55
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