BIBC100 - Summer Session I, 2008, Dr. Lukas Buehler Syllabus ...

BIBC100 - Summer Session I, 2008, Dr. Lukas Buehler
Syllabus - Structural Biochemistry BIBC 100
Instructor: Dr. Lukas Buehler
Lecture: MTWTh 11:00am-12:20pm, Solis 104
Office Hours: T Th 2:30pm- 3:30pm, Bonner Hall 3220 Lbuehler@ucsd.edu
Week Day Lecture topics Voet, Pratt * Reader Comments
1 M 6/30 Introduction, water 1 Intro, 1.1
T 7/1 Solubility 2 1.1
W 7/2 Amino acids 4 1.2
R 7/3 Peptides and proteins 6 1.3
2 M 7/7 Secondary structures 6 1.3, 1.8
Tu 7/8 Protein motifs 6 1.3
W 7/9 Nucleic acid structures 3, 24, 27 1.4, 1.5
R 7/10 DNA stability 24 1.4 Midterm Exam (30%)
3 M 7/14 DNA-binding proteins 24, 27 3.2, 3.1
T 7/15 Polysaccharides 8 1.6
W 7/16 Glycoproteins, glycolipids 8 1.6, 3.5
R 7/17 Lipids, cell membranes 9 1.7
4 M 7/21 Membrane fluidity 9 1.7, 3.7
T 7/22 Binding specificity:
enzymes
11, 12 2.1
W 7/23 Binding specificity:
transporters
10 2.4 Midterm Exam (30%)
R 7/24 Binding Affinity:
hemoglobin
7 2.2
5 M 7/28 Binding Affinity:
calmodulin
13, 10 2.3
T 7/29 Protein motion 6, 18 2.6, 3.4
W 7/30 Protein folding and
stability
6 2.7
R 7/31 Structure prediction 6, 12 2.4, 3.8
Sat 8/2 FINAL 8:00am-10:50am Not cumulative (40%)
� From Voet et al., Fundamentals in Biochemistry, 3 rd edition, 2008
� Many times only parts of a book chapter are covered, please refer to lecture notes,
slides, and reader to narrow your reading to appropriate content.
� Office hours are offered every day from 2:30 to 3:30pm in Bonner Hall 3230. The above
times are priority days for this class; the other two days are priority days for the other
biochemistry class
� NOTE: the final exam is held on Saturday, August 2. You need to be able to attend on
Saturday. Last day of class is not a Thursday or Friday!
The class outline is subject to changes announced during class and posted on the class web
page at: http://www.biology.ucsd.edu/classes/bibc100.SU1.08/

Text Books
Structural Biochemistry, 2 nd
(class reader)
by Lukas K. Buehler
J.Wiley & Sons
TA Sections
BIBC100 - Summer Session I, 2008, Dr. Lukas Buehler
Fundamentals of
Biochemistry, 3 rd , 2008
by Voet, Voet and Pratt
J.Wiley & Sons, 2005
Section Day Time Location Room
A01 M 1:00p - 2:50p SOLIS 111
A02 Tu 2:00p - 3:50p SOLIS 111
A03 W 1:00p - 2:50p SOLIS 111
A04 W 3:00p - 4:50p SEQUO 147
A05 Th 09:00a - 10:50a SOLIS 109
Policies regarding exams and regrading
Regrading
Regrades for midterms will be allowed and have to be submitted no later than one week from the
time you receive the graded exams. It is the responsibility of TAs grading a particular problem to
make corrections or adjustments. You can submit a written request for more than one problem.
Those requests will be regraded during a regrading session after the one week period allotted to
submit a request.
Make up exams
Midterms are held during class time. Makeup exams are available for emergency reasons and
conflicts with other assignments for which students have no control over the timing. For conflicts
regarding the final exam and having more than two (=3) final exams within a 24-hour period, you
need to contact your college administration to request make up exams. You should do this during
the first week of class and as soon as you are aware of such clustering. There are no makeup
finals if you (or some relatives) make travel arrangements before the end of the scheduled final
exam.
Cheating
To avoid cheating problems, please write in pen and not pencil. If you make changes, mark them
clearly (cross out) and do not erase and write over other words. A small number of exams will be
photo copied (after grading and before students receive them) and compared with the submitted
regrade request. Photocopies are done randomly and are not a systematic approach nor are they
targeting any students in particular. Cheating will be reported to the Dean of your college.