Curriculum Vitae - NMR Spectroscopy Research Group

Curriculum Vitae of Klaartje Houben, July 20082000 BNRA course “From data to Structures”, Nijmegen-Utrecht, The Netherlands (May/June 3weeks)EMBO course “Multidimensional NMR in Structural Biology”, Il Ciocco, Italy (August 13-18)1999 BNRA course “Advanced NMR Spectroscopy”, Nijmegen-Utrecht, The Netherlands(May/June 3 weeks)Teaching experiences & qualifications2007 Lecturer in 3 rd year Chemistry Structural Biology course: Basics of NMR2006 Qualification Maître de Conférence (Analytical Chemistry, Organic Chemsitry,Biochemistry) in France2005 Lecturer in the graduate course ‘Advanced NMR spectroscopy’ Utrecht-Nijmegen (6& 7 june 2005): Protein dynamics characterized by NMR2002-2003 Supervisor Last Year Research Project Undergraduate (Sanne Nabuurs)“NMR Relaxation of CI2: Measurements & Analysis”2000 - Assistant analytical chemistry 2 nd year practical course (150 hrs), Faculty ofChemistry, Utrecht University- Assistant analytical chemistry 1 st year practical course (100 hrs), Faculty ofChemistry (Natuurwetenschappen), Utrecht University1998 Assistant analytical chemistry 1 st year practical course (120 hrs), Faculty ofPharmaceutical Sciences, Utrecht UniversityOrganizational activities2006 Organization of Ph.D. and post-doc meetings at the IBS Grenoble2006 Organization ‘Fête de la Science’ (http://www.enseignementsuprecherche.gouv.fr/fete/2006/)at the IBS Grenoble2005 Organization ‘Fête de la Science’ (http://www.recherche.gouv.fr/fete/2005) at the IBSGrenoble2000-2003 Member of the board of the NMR department (in charge of teaching-duties)2000-2002 Member of the Ph.D. student platform of the Bijvoet Center of Biomolecular ResearchPublications:Malene Ringkjøbing Jensen, Klaartje Houben, Ewen Lesop, Laurence Blanchard, Rob W.H. Ruigrokand Martin Blackledge. Quantitative Conformational Analysis of Partially Folded Proteins fromResidual Dipolar Couplings: Application to the Molecular Recognition Element of Sendai VirusNucleoprotein (2008), JACS 130(25), 8055-8061Klaartje Houben, Laurence Blanchard, Martin Blackledge and Dominique Marion. Intrinsic dynamicsof the partly folded PX domain from the Sendai virus RNA polymerase co-factor P (2007), BiophysicalJ. 93(8), 2830-2844Klaartje Houben, Dominque Marion, Nicolas Tarbouriech, Rob W.H. Ruigrok and LaurenceBlanchard. INTERACTION OF THE C-TERMINAL DOMAINS OF SENDAI VIRUS N AND P PROTEINS: Comparisonof polymerase-nucleocapsid interaction within the paramyxovirus family (2007), J. Virol. 81(13),Page 2 of 5

in Sendai Virus, Gordon Conference, Aussois, FranceCurriculum Vitae of Klaartje Houben, July 20082005: Dynamics of Sendai virus phosphoprotein X-domain (PX) from NMR 15 N and 2 H NMR relaxationrates, VIII ième Rencontre Rhône-Alpes de RMN, Grenoble, France2005: NMR studies of the dynamics and metal exchange properties of two C4C4 RING domains,EUROMAR/EENC, Veldhoven, The Netherlands2005: Development and application of NMR relaxation methods to study protein structure anddynamics, Institute of Molecular Biology and Biophysics, ETH Zürich, Switzerland (host: Prof. Dr. F.Alain)2004: NMR studies on protein side chain dynamics using 13 C- 13 C cross-relaxation, NWO-CW meeting:Ontwerp & Synthese, Structuur & Reactiviteit and Biomoleculaire Chemie, Lunteren, The Netherlands2004: I. Structure and dynamics of UbcH5B, II. Side chain dynamics using 13 C- 13 C cross-relaxation,Laboratoire de RMN, IBS, Grenoble, France (host: Dr. D. Marion)2003: Protein Dynamics by NMR, Bijvoet Autumn School ‘Folding and Dynamics’, The Netherlands2002: 13 C- 13 C cross-relaxation as a tool for studying side chain dynamics, Biophysical Chemistry,Lund University, Sweden (host: Prof. Dr. M. Akke)2002: Side Chain Dynamics Monitored by 13 C- 13 C cross-relaxation, 43 rd ENC, Asilomar, USAPoster presentations2008: Bijvoet Anniversary Symposium, Utrecht, The NetherlandsStudying small membrane proteins with NMR, Klaartje Houben, Gert E. Folkers, Joost C. Holthuisand Rolf Boelens2007: EUROMAR, Tarragona, SpainDynamics and interaction of two (partially) unstructured viral domains, Klaartje Houben, LaurenceBlanchard, Nicolas Tarbouriech, Martin Blackledge, Rob Ruigrok & Dominique Marion2006: Gordon Conference, Aussois, FranceDynamics of the partly folded PX domain that indispensible for RNA synthesis in Sendai virus,Klaartje Houben, Laurence Blanchard, Nicolas Tarbouriech, Martin Blackledge, Rob Ruigrok &Dominique Marion2005: VIII ième Rencontre Rhône-Alpes de RMN, Grenoble, FranceDynamics of Sendai virus phosphoprotein X-domain (PX) from NMR 15 N and 2 H NMR relaxationrates, Klaartje Houben, Laurence Blanchard, Nicolas Tarbouriech, Martin Blackledge, Rob Ruigrok& Dominique Marion2005: EUROMAR/EENC, Veldhoven, The NetherlandsNMR studies of the dynamics and metal exchange properties of two C4C4 RING domains, KlaartjeHouben, Emeric Wasielewski, Cyril Dominguez, Esther Kellenberger, R. Andrew Atkinson, H. Th.Marc Timmers, Bruno Kieffer and Rolf Boelens2003: 7 th European Large Scale Facility User Meeting, Oosterbeek, The NetherlandsDynamics and Structure Refinement of UbcH5B using 15 N Relaxation Parameters, KlaartjeHouben, Cyril Dominguez, Alexandre M.J.J. Bonvin, Frederick M.A. van Schaik, Marc Timmersand Rolf BoelensSide Chain Dynamics in Proteins: Comparing Simulation with NMR data, Aaltjan D.J. van Dijk,Klaartje Houben, Rolf Boelens and Alexandre M.J.J. BonvinRelaxation of Chymotrypsin Inhibitor 2: Measurements and Analysis, Sanne Nabuurs, KlaartjeHouben and Rolf Boelens2002: XX th ICMRBS, Toronto, CanadaSide Chain Dynamics monitored by 13 C- 13 C cross-relaxation, Klaartje Houben and Rolf BoelensPage 4 of 5

2002: 6 th European Large Scale Facility User Meeting, Montecatini, ItalyCurriculum Vitae of Klaartje Houben, July 2008Side Chain Dynamics monitored by 13 C- 13 C cross-relaxation, Klaartje Houben and Rolf Boelens2001: 5 th European Large Scale Facility User Meeting, Frankfurt, GermanyRapid protein fold determination using secondary chemical shifts and cross-hydrogen bond 15 N-13 C’scalar couplings ( 3hb J NC’ ), Alexandre M.J.J. Bonvin, Klaartje Houben, Marc Guenneugues, RobKaptein and Rolf BoelensScholarships and prizes- NOW ‘Veni’ young researchers fellowship (2007): 3 years research funding- C.N.R.S. campagne de recrutement de post-doctorants (2006): 1 year post-doc- EUROMAR conference grant (2005)- Ministère délégué à la Recherche (2005): 1 year post-doc- NWO-Talent Fellowship (2004): 1 year post-doc- Student Travel Stipend of the 43 rd ENC (2002)ReferencesProf. dr. Rolf BoelensDr. Alexandre M.J.J BonvinBijvoet Center for Biomolecular Research Bijvoet Center for Biomolecular ResearchNMR spectroscopy research groupNMR spectroscopy research groupPadualaan 8 Padualaan 83584 CH Utrecht 3584 CH UtrechtThe NetherlandsThe Netherlands+31 (0)30 253 4035 +31 (0)30 253 3859R.Boelens@uu.nlA.M.J.J.Bonvin@uu.nlProf. dr. Gerrit van MeerDr. Joost C.M. HolthuisBijvoet Center for Biomolecular Research Bijvoet Center for Biomolecular ResearchMembrane EnzymologyMembrane EnzymologyPadualaan 8 Padualaan 83584 CH Utrecht 3584 CH UtrechtThe NetherlandsThe Netherlands+31 (0)30 253 3427 +31 (0)30 253 6630G.VanMeer@uu.nlJ.C.Holthuis@uu.nlDr. Dominique MarionDr. Martin BlackledgeInstitut de Biologie StructuraleInstitut de Biologie StructuraleLaboratiore de RMNLaboratiore de RMN41 rue Jules Horowitz 41 rue Jules Horowitz38027 Grenoble 38027 GrenobleFranceFrance+33 (0)438 78 36 98 +33 (0)438 78 95 54Dominique.Marion@ibs.frMartin.Blackledge@ibs.frPage 5 of 5