Volume 2 - Issue 1 (Nov-Jan) - IJMD

original researchcalcium and phosphate ion activities, thereby helpingto maintain a state of supersaturation with respectto the enamel, 14 thus depressing demineralizationand promoting remineralization. Studies have shownthat higher concentration of CPP-ACP elicit higherremineralization. 15,16CPP-ACP can be incorporated into the pelliclein exchange for albumin to inhibit the adherenceof S. mutans and S. sobrinus thus producing bothneutralization and enhancement of remineralization(Schupbach et al). Therefore, CPP-ACP can beexpected to be effective in high-risk children who havenot developed good oral hygiene habits. 17Tooth mousse can be used to prevent root caries asits application prevented demineralization of dentindue to buffering capacity of the agent. Casein buffersplaque acid directly or indirectly through bacterialcatabolism. This agent also releases basic amino acidswhich accept proton ions thus when applied on rootdentin acts as an inert barrier preventing diffusionof protons. This agent also has the ability to releasecalcium thus depressing demineralization. 18CPP-ACP when used in combination with fluoridesshowed better results and lower caries score than whenused individually. Our study also substantiates thatwhen CPP-ACP was used after fluoridated paste thebenefits of both the agents are enhanced.The findings of our study shows that when CPP-ACP was applied, the increase in remineralization anddecrease in lesion depth was greater as compared tofluoridated paste and nonfluoridated paste showed anincrease in lesion depth and demineralization.ConclusionBased on the data obtained it can be concluded thatCPP-ACP effectively decreases the lesion depth betterthan fluoridated toothpaste and nonfluoridated toothpaste which showed no improvement in the lesionsize. Efficiency of remineralization can be increasedwhen CPP-ACP and fluoridated tooth pastes are usedtogether.References1.Wefel JS, Jensen ME, Triolo PT, Faller RV, HoganMM, Bowman WD. De/remineralization from sodiumfluoride dentifrices. Am J Dent 1995;8(4):217-20.2.3.4.5.6.7.8.9.10.11.12.13.14.15.Reynolds EC. Remineralization of enamel subsurfacelesions by casein phosphopeptide-stabilized calciumphosphate solutions. J Dent Res 1997;76(9):1587-95.Iijima Y, Cai F, Shen P, Walker G, Reynolds C, ReynoldsEC. Acid resistance of enamel subsurface lesionsremineralized by a sugar-free chewing gum containingcasein phosphopeptide-amorphous calcium phosphate.Caries Res 2004;38(6):551-6.Kariya S, Sato T, Sakaguchi Y, Yoshii E. Fluoride effecton acid resistance capacity of CPP-ACP containingmaterial. Abstract 2045 - 82nd General Session of theIADR 2004, Honolulu, Hawaii.Yamaguchi K, Miyazaki M, Takamizawa T, Inage H,Moore BK. Effect of CPP-ACP paste on mechanicalproperties of bovine enamel as determined by anultrasonic device. J Dent 2006;34(3):230-6.Kumar VL, Itthagarun A, King NM. The effect ofcasein phosphopeptide-amorphous calcium phosphateon remineralization of artificial caries-like lesions: an invitro study. Aust Dent J 2008;53(1):34-40.ten Cate JM, Duijsters PP. Alternating demineralizationand remineralization of artificial enamel lesions. CariesRes 1982;16(3):201-10.Itthagarun A, Wei SH, Wefel JS. Morphology of initiallesions of enamel treated with different commercialdentifrices using a pH cycling model: scanning electronmicroscopy observations. Int Dent J 1999;49(6):352-60.Itthagarun A, Wei SH, Wefel JS. The effect of differentcommercial dentifrices on enamel lesion progression: anin vitro pH-cycling study. Int Dent J 2000;50(1):21-8.Arends J, ten Bosch JJ. Demineralization andremineralization evaluation techniques. J Dent Res1992;71 Spec No:924-8.Rahiotis C, Vougiouklakis G. Effect of a CPP-ACP agenton the demineralization and remineralization of dentinein vitro. J Dent 2007;35(8):695-8.Burke FJ. From extension for prevention to preventionof extension: (minimal intervention dentistry). DentUpdate 2003;30(9):492-8, 500, 502.Reynolds EC, Cai F, Shen P, Walker GD. Retention inplaque and remineralization of enamel lesions by variousforms of calcium in a mouthrinse or sugar-free chewinggum. J Dent Res 2003;82(3):206-11.Reynolds EC, Cain CJ, Webber FL, Black CL, Riley PF,Johnson IH, et al. Anticariogenicity of calcium phosphatecomplexes of tryptic casein phosphopeptides in the rat. JDent Res 1995;74(6):1272-9.Reynolds EC. The prevention of sub-surfacedemineralization of bovine enamel and change in plaque368Indian Journal of Multidisciplinary Dentistry, Vol. 2, Issue 1, November 2011 to January 2012