Lynette Masters Neuroradiologist

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WHAT IS fMRI?• a real time method of brain imaging• neuronal activity is NOT directly observedbut rather the effects of local increases inblood flow and changes in microvascularoxygenation, and more importantlydeoxyHb levels.• these haemodynamic responses producesmall changes in tissue contrast
“BOLD” IMAGING• Microvascular MR signal is stronglyinfluenced by the oxygenation state of Hb• deoxyHb (paramagnetic) tends to reduce thelocal MR signal by creating microscopicfield gradients• changes in oxygen saturation produce the“blood oxygenation level dependent-BOLD ” effect
Page 1 and 2: Lynette MastersNeuroradiologist
Page 3 and 4: • Lateral pain system(sensory-dis
Page 5 and 6: • High resolutionstructural imagi
Page 7: • Functional MRI (fMRI)• Diffus
Page 11 and 12: “BOLD” IMAGINGRESTACTIVATION100
Page 13 and 14: Right hand tapping
Page 16 and 17: • Hemodynamic- Response time of b
Page 18 and 19: PAIN INVESTIGATIONS• Pain Relief-
Page 20 and 21: • Chronic Pain- Difficult because
Page 23 and 24: • Intra & interhemispheric cortic
Page 25 and 26: MacIver et al, Brain, 2008
Page 27 and 28: Moulton et al, PLoS ONE, 2008
Page 29 and 30: • PET measures cerebral blood flo
Page 31 and 32: • The majority of clinical brain
Page 33: PEAK NAMING
Page 36 and 37: DIFFUSION TENSORIMAGING (DTI)• MR
Page 38 and 39: COMBINED FA & DIRECTIONALMAPS• co
Page 40 and 41: cingulumcorpus callosum corticospin
Page 43: • Tailored diagnosis +/- evaluati

Lynette Masters Neuroradiologist

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