Molecular Biology - The Scripps Research Institute
Molecular Biology - The Scripps Research Institute
Molecular Biology - The Scripps Research Institute
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DEPARTMENT OF<br />
MOLECULAR BIOLOGY<br />
STAFF<br />
Peter E. Wright, Ph.D.*<br />
Professor and Chairman<br />
Cecil H. and Ida M. Green<br />
Investigator in Medical<br />
<strong>Research</strong><br />
Ruben Abagyan, Ph.D.<br />
Professor<br />
Carlos F. Barbas III, Ph.D.*<br />
Professor<br />
Janet and W. Keith Kellogg II<br />
Chair, <strong>Molecular</strong> <strong>Biology</strong><br />
Michael N. Boddy, Ph.D.<br />
Assistant Professor<br />
Charles L. Brooks III, Ph.D.<br />
Professor<br />
Monica J. Carson, Ph.D.**<br />
Associate Professor<br />
University of California<br />
Riverside, California<br />
David A. Case, Ph.D.<br />
Professor<br />
Geoffrey Chang, Ph.D.*<br />
Associate Professor<br />
Jerold Chun, M.D., Ph.D.<br />
Professor<br />
Lisa Craig, Ph.D.**<br />
Assistant Professor<br />
Simon Fraser University<br />
Burnaby, British Columbia<br />
Valerie De Crecy Lagard,<br />
Ph.D.**<br />
Assistant Professor<br />
University of Florida<br />
Gainesville, Florida<br />
Luis De Lecea, Ph.D.<br />
Associate Professor<br />
Lluis Ribas De Pouplana,<br />
Ph.D.<br />
Adjunct Assistant Professor<br />
Ashok Deniz, Ph.D.<br />
Assistant Professor<br />
Published by TSRI Press ®. ©Copyright 2005,<br />
<strong>The</strong> <strong>Scripps</strong> <strong>Research</strong> <strong>Institute</strong>. All rights reserved.<br />
H. Jane Dyson, Ph.D.<br />
Professor<br />
John H. Elder, Ph.D.<br />
Professor<br />
Martha J. Fedor, Ph.D.*<br />
Associate Professor<br />
James Arthur Fee, Ph.D.<br />
Professor of <strong>Research</strong><br />
Elizabeth D. Getzoff,<br />
Ph.D.****<br />
Professor<br />
David B. Goodin, Ph.D.<br />
Associate Professor<br />
David S. Goodsell Jr., Ph.D.<br />
Associate Professor<br />
Joel M. Gottesfeld, Ph.D.<br />
Professor<br />
Robert Hallewell, D.Phil.<br />
Adjunct Associate Professor<br />
Jennifer Harris, Ph.D.<br />
Assistant Professor of<br />
Biochemistry<br />
Christian A. Hassig, Ph.D.<br />
Adjunct Assistant Professor<br />
Mirko Hennig, Ph.D.<br />
Assistant Professor<br />
John E. Johnson, Ph.D.<br />
Professor<br />
Gerald F. Joyce, M.D.,<br />
Ph.D.*****<br />
Professor<br />
Ehud Keinan, Ph.D.<br />
Adjunct Professor<br />
Richard A. Lerner, M.D.,<br />
Ph.D.*****<br />
President, <strong>Scripps</strong> <strong>Research</strong><br />
Lita Annenberg Hazen Professor<br />
of Immunochemistry<br />
Cecil H. and Ida M. Green<br />
Chair in Chemistry<br />
Scott Lesley, Ph.D.<br />
Assistant Professor of<br />
Biochemistry<br />
Tianwei Lin, Ph.D.<br />
Assistant Professor<br />
Clare McGowan, Ph.D. †<br />
Associate Professor<br />
Duncan E. McRee, Ph.D.<br />
Adjunct Associate Professor<br />
David P. Millar, Ph.D.<br />
Associate Professor<br />
Louis Noodleman, Ph.D.<br />
Associate Professor<br />
Arthur J. Olson, Ph.D.<br />
Professor<br />
James C. Paulson, Ph.D. ††<br />
Professor<br />
Vijay Reddy, Ph.D.<br />
Assistant Professor<br />
Steven I. Reed, Ph.D. †<br />
Professor<br />
Victoria A. Roberts, Ph.D.**<br />
Associate Professor<br />
University of California<br />
San Diego, California<br />
Paul Russell, Ph.D.<br />
Professor<br />
MOLECULAR BIOLOGY 2005 155<br />
Michel Sanner, Ph.D.<br />
Associate Professor<br />
Harold Scheraga, Ph.D.<br />
Adjunct Professor<br />
Paul R. Schimmel, Ph.D.*****<br />
Ernest and Jean Hahn<br />
Professor of <strong>Molecular</strong><br />
<strong>Biology</strong> and Chemistry<br />
Anette Schneemann, Ph.D.<br />
Associate Professor<br />
Subhash C. Sinha, Ph.D.*<br />
Associate Professor<br />
Gary Siuzdak, Ph.D.<br />
Adjunct Associate Professor<br />
Robyn L. Stanfield, Ph.D.<br />
Assistant Professor<br />
James Steven, Ph.D.<br />
Assistant Professor<br />
Raymond C. Stevens, Ph.D. †††<br />
Professor<br />
Charles D. Stout, Ph.D.<br />
Associate Professor<br />
Peiqing Sun, Ph.D.<br />
Assistant Professor<br />
J. Gregor Sutcliffe, Ph.D.<br />
Professor<br />
John A. Tainer, Ph.D.*<br />
Professor<br />
Fujie Tanaka, Ph.D.<br />
Assistant Professor<br />
Elizabeth Anne Thomas, Ph.D.<br />
Assistant Professor<br />
SECTION COVER FOR THE DEPARTMENT OF MOLECULAR BIOLOGY: Toll-like<br />
receptors (TLRs) recognize various pathogen-associated molecules and play an important role in<br />
innate immune responses. <strong>The</strong> human TLR3 recognizes double-stranded RNA from viruses and initiates<br />
an intracellular signaling pathway through the interaction of TIR domains of TLR3 and the<br />
adaptor molecule TRIF. <strong>The</strong> proposed dimer of the TLR3 ectodomain is displayed on the membrane<br />
surface with double-stranded RNA from viruses. <strong>The</strong> crystal structure was determined by Jungwoo<br />
Choe, Ph.D., in the laboratory of Ian A. Wilson, D.Phil.
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