A Clinical Study to Evaluate the Effect of Extract Based ... - IJGHC

E-ISSN: 2278-3229International Journal of Green and Herbal ChemistryAvailable online at www.ijghc.orgGreen ChemistryIJGHC; September-November, 2012; Vol.1.No.3, 374-380.Research ArticleA Clinical Study to Evaluate the Effect of Extract BasedHerbal Formulation on Hypertension- A Single BlindedStandard Controlled Randomized StudyDr Satish Agrawal ** and Dr Hemant Pol ***Associate Professor, Department of Kayachikitsa , Shubhdeep Ayurved Medical College & Hospital,Khandwa Road, Indore -452020*Assistant Professor, Department Of Samhita Siddhant, Shubhdeep Ayurved Medical College & Hospital,Khandwa Road, Indore -452020Received: 20 September 2012; Revised: 28 October 2012; Accepted: 31 October 2012.Abstract: Hypertension is the one of the major burning health problem which thesociety is facing presently. In spite of achieving all the comforts of life, still menhas surrounded himself in stressful environment because of his undisciplined dietaryand daily regimen, which is the main cause of Hypertension. Presently majority ofIndian population is suffering from Hypertension, out of which more than 94%cases belong to Primary Hypertension for which multifactorial mechanism such asoveractivity of renin angiotensin system, increased sympathetic activity, increasedsalt intake, early atherosclerotic changes due to faulty food habits, smoking &alcohol have been attributed. Moreover, the medicine needs to be taken lifelongleaving behind unnecessary side effects in majority of cases. Keeping in view thislimitation of modern science and to provide economic, simple and effectivemanagement, present study has been carried out to evaluate the clinical efficacy ofMadhuparnyadi extract based herbal formulation on above mentioned disease. Asingle blind comparative study was conducted on two groups of 25 patients each fora period of one month. Group A was given Madhuparnyadi extract based herbalformulation whereas Group B was given standard control drug (Sarpagandha rootGhanavati). Study revealed that the trial drug is significantly effective in relievingthe subjective and objective parameters of primary hypertension. Moreover it hasshown promising results on Headache and palpitation which should be studiedfurther.Keywords: Hypertension, Madhuparnyadi extract, Headache, palpitation374 IJGHC; 2012, Vol.1, No.3, 374-380.

A Clinical...Satish Agrawal and Hemant PolTable- 1: Drug compositionGuduchi stem-100mgSarphgandha root-50mgJatamansi rhizome-100mgPunarnava root-50mgShilajeet-75mgAjwain seeds-50mgNishotha root-50mgPippali fruit-25mgStandard control (active comparator) capsule contains 500 mg Ghana of Sarpagandha root.RESEARCH METHODOLOGYType of study: Single blinded comparative study.Study site: IPD and OPD department of Shubhdeep ayurved medical college, Indore (MP).Sample size: 50 patients divided randomly into two equal groups. Group A given trial drug whereas GroupB given control drug.Drug dosage and vehicle: 1 capsule twice daily with lukewarm water after meals.Duration of treatment: one month (examined at weekly intervals.)Dietary advice: To strictly restrict the daily intake of sour (amla), salty (lavana) and heavy (guru) diet.OBSERVATIONS &RESULTS• 70% Patients found to be hypertensive were above 40 years of age.• 60% Patients were fond of salty & spicy diet.• Out of 50 patients 30 patients (60%) belongs to service class.• Out of 50 patients, 35 patients (70%) were male.• Regarding prevalence of symptoms, Dyspnoea on routine work was found in 82%,Headache & palpitation in 80%, Vertigo in 78% & Fatigue in 66% patients.Table- 2: Paired‘t’ Test for Subjective parameters – group AS.No. Symptom N B.T. A.T. Diff. % SD SE ± ‘t’ PMean Mean Mean Relief1 Headache 20 1.65 0.5 1.15 69.69 0.587 0.131 8.76

A Clinical...Satish Agrawal and Hemant PolTable- 3: Paired‘t’ Test for Subjective parameters– Group BS.No Symptom NB.T.MeanA.T.MeanDifferenceMean% ReliefSD ± SE ± ‘t’ P1 Headache 20 1.1 0.6 0.5 45.45 0.69 0.15 3.25

A Clinical...Satish Agrawal and Hemant PolTable-7: Unpaired‘t’ test for Objective parameters.No. Symptom Group A Group B T D.F. PN Mean±SEM N Mean±SEM1 Systolic 25 34 ± 1.815 25 25.6 ± 0.98 4.073 48

A Clinical...Satish Agrawal and Hemant PolThe trial drug is supposed to have specific effect on circulatory and nervous system so as to relieve thepathogenesis of hypertension. Ajwain 4 and Pippali 5 pacify Kapha deposited on vessel wall and seem towork on Sanchaya, Prakopa and Prasara stage of Kriyakala. Shilajeet 6 and Pippali exerts Srotoshodhanakarma through Rasayana property and seems to work on Sthana sanshraya stage to curette the Kaphadeposited on vessel wall. It is evident that this stage occurs at the site of disease. Punarnava 7 andNishotha 8 exert diuretic action through Shothhara karma. Guduchi 9 helps in pacifying remaining Dosha.Jatamansi 10 and Sarpgandha 11 together help to reduce sympathetic hyperactivity and nervous factorsresponsible for hypertension. In other words they exert Manodoshhara karma. It has been proved bymodern researches also.Finally it can be concluded that the drug under study has shown enthusiastic results in reducing the overallvalue of blood pressure. 64% patients got effectively cured, 24% got well cured and 12% got fairly cured.Regarding symptomatic relief, out of 25 patients 8 showed more than 75% relief, 9 showed more than50% relief , 7 showed more than25% relief and only 1 patient showed less than 25% relief in overallsymptoms (Table 9). No significant side effects have been reported in any subject.To conclude, the drug under trial has shown highly promising results in treating hypertension, whichshould be assessed on larger population. It has also opened the way for treatment of other disease entitywhich is result of undisciplined dietary and daily regimen of modern society.ACKNOWLEDGEMENTWe greatly acknowledge respected Principal, hospital staff & our colleagues, Shubhdeep AyurvedMedical College & hospital Indore for extending their every possible help & well wishes tocomplete the above study.REFERENCES1. Brahman Tripathi, Charak Samhita (vol-1), Sutrasthana, Trishothiya Adhyay, Shloka no. 18/44,Varanasi Chaukhambha Surbharati Prakashan, 2009, page 378.2. Brahman Tripathi , Charak Samhita (vol-2), Chikitsasthana, Vatvyadhi Adhyay, Shloka no. 28/59,Varanasi Chaukhambha Surbharati Prakashan, 2009, page 948.3. Brahman Tripathi , Charak Samhita (vol-1), Sutrasthana, Dirghamjivitiya Adhyay, Shloka no.1/66, Varanasi Chaukhambha Surbharati Prakashan, 2009, page 36.4. Dr. K.C. Chunekar, commentary edited by G.S. Pandey, Bhavaprakash Nighantu HaritkyadiVarga, Shloka 76, Varanasi Chaukhambha Bharati Academy, reprint 2004, page 25.5. Dr. K.C. Chunekar, commentary edited by G.S. Pandey, Bhavaprakash Nighantu HaritkyadiVarga, Shloka 58, Varanasi Chaukhambha Bharati Academy, reprint 2004, page 15.6. Indradev Tripathi, Raj Nighantu Guduchyadi , Varga Shloka 73, Varanasi, ChaukhambaKrishnadas Academy, 2003, page 433.7. Dr. K.C. Chunekar, commentary edited by G.S. Pandey, Bhavaprakash Nighantu GuduchyadiVarga, Shloka 231, Varanasi Chaukhambha Bharati Academy, reprint 2004, page 422.379 IJGHC; 2012, Vol.1, No.3, 374-380.

A Clinical...Satish Agrawal and Hemant Pol8. Dr. K.C. Chunekar, commentary edited by G.S. Pandey, Bhavaprakash Nighantu GuduchyadiVarga, Shloka 194, Varanasi Chaukhambha Bharati Academy, reprint 2004, page 397.9. Indradev Tripathi, Raj Nighantu Guduchyadi, Varga Shloka 17-18, Varanasi, ChaukhambaKrishnadas Academy, 2003, page 31.10. Database on Medicinal plants used in Ayurveda, Volume 7 CCRAS, New Delhi, 2005, p136-139.11. Database on Medicinal plants used in Ayurveda, Volume 7 CCRAS, New Delhi, 2005, p387- 390.*Correspondence Author: Dr Satish Agrawal; Associate professor,Department of Kayachikitsa , Shubhdeep Ayurved Medical College & Hospital,Khandwa Road, Indore -452020380 IJGHC; 2012, Vol.1, No.3, 374-380.