Cardiac Regeneration and Cell Therapy - Herzzentrum Uniklinik Koeln
Cardiac Regeneration and Cell Therapy - Herzzentrum Uniklinik Koeln
Cardiac Regeneration and Cell Therapy - Herzzentrum Uniklinik Koeln
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Friday, May 13 th , 2011<br />
9:00 – 9:10 Welcome address, M. Paulsson<br />
Associate Dean (Research) of the Medical Faculty<br />
9:10 – 9:20 Welcome address, J. Hescheler<br />
Speaker of the BMBF consortium<br />
Session 1: Embryonic Heart Development<br />
Chairs: C. Mummery, J. Hescheler<br />
9:20 – 9:50 Jolanta Chmielowiec<br />
Chemical screening <strong>and</strong> iPS cell model systems define role of TGF-β<br />
signaling in islet heart progenitors<br />
9:50 – 10:20 Marc Mercola<br />
Natural <strong>and</strong> synthetic inducers of heart differentiation<br />
10:20 – 10:50 Antoon F. Moorman<br />
<strong>Cardiac</strong> growth<br />
Coffee Break 10:50 – 11:20<br />
Session 2: Sources of Stem <strong>Cell</strong>s for <strong>Cardiac</strong> Repair I<br />
Chairs: M. Roberts, T. Saric<br />
11:20 – 11:40 Wolfram Zimmermann<br />
Parthenogenetic stem cells for cardiac repair<br />
11:40 – 12:00 Kaomei Guan<br />
Pluripotent germ line stem cells for cardiac repair<br />
12:00 – 12:20 Dinender Singla<br />
TGF-β2-primed ES cells in cardiac repair <strong>and</strong> regeneration<br />
12:20 – 12:40 Marie-Jose Goumans<br />
Human cardiomyocyte progenitor cells: Maturation <strong>and</strong> functional<br />
impact<br />
12:40 – 13:00 Wolfgang Franz<br />
Forward programming of pluripotent stem cells towards<br />
cardiomoycytes<br />
Lunch Break 13:00 -14:00<br />
Session 3: Sources of Stem <strong>Cell</strong>s for <strong>Cardiac</strong> Repair II<br />
Chairs: D. Singla, J. Müller-Ehmsen<br />
14:00 – 14:20 Christine Mummery<br />
Opportunities <strong>and</strong> challenges in using stem cells for cardiac repair<br />
14:20 – 14:40 Clifford Folmes/Andre Terzic<br />
Metabolic dynamics in nuclear reprogramming<br />
14:40 – 15:00 Michael Roberts<br />
iPS cells from swine: Potential for cardiac repair in a large animal<br />
model<br />
15:00 – 15:20 Robert Zweigerdt<br />
Scalable differentiation of pluripotent stem cells towards<br />
cardiomyocytes<br />
15:20 – 15:40 Masaki Ieda<br />
A new method for cardiac regeneration: Direct conversion of<br />
fibroblasts into cardiomyocytes by defined factors<br />
Coffee Break 15:40 – 16:10<br />
Session 4: Properties of Stem <strong>Cell</strong> Derived Cardiomyocytes<br />
Chairs: B. Fleischmann, S. Herzig<br />
16:10 – 16:25 Marcel Halbach<br />
Integration <strong>and</strong> maturation of cells<br />
16:25 – 16:40 Tomo Saric<br />
Transcriptional profiles of ES <strong>and</strong> iPS cell derived cardiomyocytes<br />
16:40 – 17:05 Martin Morad<br />
Maturation of calcium h<strong>and</strong>ling in cardiomyocytes during development<br />
17:05 – 17:30 Lior Gepstein<br />
Transplantation of a tissue-engineered human vascularized cardiac<br />
muscle<br />
17:30 – 17:55 Linda van Laake<br />
Comparison of murine ES <strong>and</strong> iPS cell-derived cardiomyocytes<br />
17:55 – 18:10 Markus Khalil<br />
Contractile behavior of native murine ventricular tissue <strong>and</strong><br />
cardiomyocytes derived from ES or iPS cells<br />
19:30 Dinner<br />
Saturday, May 14 th , 2011<br />
Session 5: (Epi)genetic Modifications of Therapeutic <strong>Cell</strong>s<br />
Chairs: M. Mercola, J. C. Wu<br />
9:00 – 9:25 Alex<strong>and</strong>er Meissner<br />
Epigenetic modifications in pluripotent <strong>and</strong> differentiated cells<br />
9:25 – 09:50 Frank Edenhofer<br />
Engineering cell-permeant FLP recombinase for tightly controlled<br />
inducible <strong>and</strong> reversible overexpression in ES cells<br />
09:50 – 10:15 John Listello<br />
Zinc finger nuclease (ZFN)-Engineering of iPS cells for cardiac<br />
specific lineage tags<br />
10:15 – 10:40 Szuszanna Izsvak<br />
Transposons as tools for genetic modification of stem cell derivatives<br />
Coffee Break 10:40 – 11:10<br />
Session 6: Tissue Engineering / <strong>Cell</strong> Delivery<br />
Chairs: W. Zimmermann, Y.-H. Choi<br />
11:10 – 11:35 Gordana Vunjak-Novakovic<br />
Scaffold stiffness <strong>and</strong> functional properties of 3D cardiac constructs<br />
11:35 – 12:00 Doug Cowan<br />
<strong>Cell</strong>-based therapy for pediatric heart block<br />
12:00 – 12:25 Kevin Healy<br />
Two-photon-initiated polymerization for creation of 3D scaffolds for<br />
tissue engineering<br />
12:25 – 12:50 Jonathan Leor<br />
Biomaterials <strong>and</strong> the efficacy of cell therapy<br />
12:50 – 13:00 Benjamin Krausgrill<br />
In vivo tissue engineering<br />
Lunch Break 13:00 – 14:00<br />
Session 7: In vivo Imaging of Grafted <strong>Cell</strong>s/Large Animal Models<br />
Chairs: G. Vunjak-Novakovic, F. Pillekamp<br />
14:00 – 14:15 Klaus Neef<br />
Serial in vivo cell tracking <strong>and</strong> evaluation of cell therapeutic effects by<br />
MRI<br />
14:15 – 14:40 Joseph C. Wu<br />
Pluripotent stem cells: biological insights from molecular imaging<br />
14:40 – 15:05 Philip Sasse<br />
Optogenetic control of heart muscle in vitro <strong>and</strong> in vivo<br />
15:05 – 15:20 Dennis Ladage<br />
Pre-clinical large animal studies on cardiac regeneration<br />
Coffee Break 15:20 – 15:45<br />
Session 8: Pre-Clinical <strong>and</strong> Clinical Approaches to <strong>Cardiac</strong><br />
<strong>Regeneration</strong><br />
Chairs: A. Terzic, T. Wahlers<br />
15:45 – 16:10 Roger J. Hajjar<br />
In vivo myocardial distribution of multipotent progenitor cells following<br />
intracoronary delivery in a swine model of myocardial infarction<br />
16:10 – 16:30 Christof Stamm<br />
Clinical studies on cardiac repair with adult stem cells - the surgeon’s<br />
view<br />
16:30 – 16:50 Stefan Janssens<br />
Clinical studies on cardiac repair with adult stem cells - the<br />
cardiologist’s view<br />
16:50 – 17:15 Atta Behfar/Andre Terzic<br />
Lineage-specified cardiopoietic stem cell therapy for heart failure<br />
17:15 – 17:35 Christina Mauritz<br />
iPS cell-derived Flk-1 progenitor cells engraft, differentiate <strong>and</strong><br />
improve heart function in a mouse model of acute myocardial<br />
infarction<br />
17:35 – 18:00 Barbara Pfüller<br />
Obstacles to meet in the bench-to-bedside translation<br />
18:00 – 18:10 Concluding Remarks
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