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8.5 Geriatric UseIn the short-term controlled clinical trials of Valturna, 99 (15.9%) patientstreated with Valturna were ≥65 years and 14 (2.2%) were ≥75 years.No overall differences in safety or effectiveness were observed between thesesubjects and younger subjects, and other reported clinical experience has notidentified differences in responses between the elderly and younger patients, butgreater sensitivity of some older individuals cannot be ruled out.10 OVERDOSAGEAliskirenLimited data are available related to overdosage in humans. The most likelymanifestation of overdosage would be hypotension. If symptomatic hypotensionoccurs, provide supportive treatment.ValsartanLimited data are available related to overdosage in humans. The most likely effectof overdose with valsartan would be hypotension and tachycardia; bradycardiacould occur from parasympathetic (vagal) stimulation. Depressed level of consciousness,circulatory collapse and shock have been reported. If symptomatichypotension occurs, provide supportive treatment.Valsartan is not removed from the plasma by hemodialysis.Valsartan was without grossly observable adverse effects at single oral doses upto 2000 mg/kg in rats and up to 1000 mg/kg in marmosets, except for the salivationand diarrhea in the rat and vomiting in the marmoset at the highest dose(60 and 31 times, respectively, the maximum recommended human dose on amg/m 2 basis). (Calculations assume an oral dose of 320 mg/day and a 60-kgpatient.)16 STORAGEStore at 25°C (77°F); excursions permitted to 15-30°C (59-86°F) in original container.[See USP Controlled Room Temperature.]Protect from moisture.Dispense in tight container (USP).REV: FEBRUARY 2010 T2010-12Manufactured by:Novartis Pharma Stein AGStein, SwitzerlandDistributed by:Novartis Pharmaceuticals CorporationEast Hanover, New Jersey 07936©Novartis
American Society of Hypertension2010 Annual Scientific Meetingand Exposition25th Anniversary, 1986–20102010 Program BookHilton New YorkSaturday, May 1, 2010 – Tuesday, May 4, 2010
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Faculty Disclosure ListingGail Adle
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you to attend thethe Innovations Th
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4 CONTRAINDICATIONSNone.5 WARNINGS
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7 DRUG INTERACTIONSNo drug interact
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8.5 Geriatric UseIn 8.5the Geriatri
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2010 ASH ExhibitorsASH Hypertension
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ASH Hypertension Resource CenterHil
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Author IndexAAbaunza, Ricardo, 122A
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Author IndexCastellano, Maurizio, 1
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Author IndexGuarneri, Marco, 146Guo
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Author IndexLekakis, John, 118, 122
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Author IndexTello, Susana, 109, 135
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Are You 1in 3?Get the facts. Know y
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