2010 Annual Scientific Meeting and Exposition 2010 Annual ...

GET ON THE BP LINE–See How NY Moves Hypertension @ ASH.IndicationTEKTURNA is indicated for the treatment of hypertension in adults.TEKTURNA may be used alone or in combination with other antihypertensiveagents. The use of TEKTURNA with maximal doses of ACE inhibitorshas not been adequately studied, and it is not known whether additiveeffects are present when TEKTURNA is used with ACE inhibitors orbeta-blockers.Important ConsiderationsWARNING: AVOID USE IN PREGNANCYWhen pregnancy is detected, discontinue TEKTURNA as soon aspossible. Drugs that act directly on the renin-angiotensin system cancause injury and even death to the developing fetus. See WARNINGSAND PRECAUTIONS (5.1).Angioedema of the face, extremities, lips, tongue, glottis and/or larynx has beenreported in patients treated with aliskiren and has necessitated hospitalizationand intubation. This may occur at any time during treatment and has occurredin patients with and without a history of angioedema with ACE inhibitors orangiotensin receptor antagonists. Discontinue TEKTURNA immediately inpatients who develop angioedema, and do not readminister.Excessive hypotension was seen rarely (0.1%) in patients with uncomplicatedhypertension treated with TEKTURNA alone. Hypotension was also infrequentduring combination therapy with other antihypertensive agents (