ABSTRACT OF POSTER PRESENTATION (APRIL 17, SATURDAY)

More documents

Recommendations

Info

P2-101 Gastroenterology P2-102 GastroenterologyTHE ROLE IN CELL DEATH INCHOLESTASIS MURINEMao-Meng Tiao, 1 Ying-Hsien Huang, 1 Kuo-Shu Tang,1 Chung-Chin Lu 21 Departments of Pediatrics, Chang Gung Memorial Hospital-KaohsiungMedical Center, Chang Gung University College of Medicine, Taiwan. 2Fooyin University Hospital, TaiwanOBJECTIVE: We find that the biogenesis ofmitochondria is response to the early stage ofcholestasis with internal pathway. The regulationpathogenesis of the liver cell apoptosis in this earlystage in cholestatic liver injury is not clear.METHODS: A rat model of cholestasis wasestablished by bile duct ligation (BDL), withsimultaneous creation of the sham group receivinglaparotomy without BDL. Liver LC3B1, LC3B2,Beclin-1, caspase 9 protein expression was analyzedby western blotting. The ATF6, IRE1, BIP RNAlevel was measured by real-time polymerase chainreaction.RESULTS: The liver LC3B-2 and LC3B2/LC3B1ratio at 6-72 hours with caspase 9 activity andBeclin-1 levels at 72 hours significant upregulated.The ATF6, IRE1, BIP significantly decreased at 24-72 hours.CONCLUSIONS: Our results indicate thatregulation of the liver biogenesis is within a fewhours after complete bile duct obstruction. Earlymurine cholestatic liver injury is via autophagypathway.[Keywords] jaundice, mitochondria, apoptosisCONSTIPATION AMONG FILIPINO CHILDREN 1MONTH – 4 YEARS OF AGE: ITS PREVALENCEAND RISK FACTORSAnthony Joseph Reyes TecsonPediatrics, Philippine Pediatric Society, PhilippineBACKGROUND: Constipation accounts for 3% of pediatricoutpatient visits and 10 to 25% of pediatric gastroenterologyvisits. A variety of factors have been proposed as precipitants.However, up until now, there are no local studies yet with regardthe prevalence and risk factors of constipation in pediatricpopulation.OBJECTIVE: To determine the prevalence and risk factors ofconstipation in infants and children 1 month to 4 years oldMETHODS: This was a Cross sectional study. All pediatricpatients aged 1 month to 4 years seen at a tertiary medical centeroutpatient department, regardless of complaint and diagnosiswere included. The information gathered were recorded in avalidated data collection form.RESULTS: A total of 276 one to four year old and 183 onemonth to 12 months old were included. The overall prevalencerate was 12.2%. The prevalence rate in children was 12.7%(35/276) while in infants it was 11.5% (21/183). There was nosignificant association between both sex and age withconstipation in infants and children. In children, family historyof constipation (OR 8.3, CI 3.42-20.17) and allergy (OR 4.74,CI 2.13-10.58) were significantly associated with constipationwhile in infants, it was family history of constipation (OR 6.4,CI 2.11-19.45) and gastrointestinal illness (OR 6.58, CI1.36-31.8). On multivariate analysis, only family history ofconstipation (p=0.001) and family history of gastrointestinalillness (p 0.049) proved to be a significant predictor ofconstipation in infants. Constipation was significantly notedamong children not eating fruits (OR 7.8, CI 3.17-19.2), noteating vegetables (OR 11.26, CI 4.76-26.87), not toilet trained(OR 5.02, CI 2.21-11.59) and those who do not use the toiletdaily to defecate (OR 4.3, CI 1.95-9.54). On multivariateanalysis, family history of constipation, family history of allergyand failure to use the toilet daily were significant factors amongconstipated children. There was no association with the use ofiron supplements (OR 0.65, CI 0.21-1.89), water intake (OR0.44, CI 0.12-5.5), diarrhea (OR 1.2, CI 0.12-5.5) and feverprior to constipation (OR 1.5, CI 0.16-8.02). Likewise there wasno association between age of passage of meconium as well thefrequency and interval of milk intake in infants withconstipation. Moreover, the use of iron supplements (OR 1.31,CI 0.27-6.33) was also not associated with constipation.CONCLUSION: The prevalence rate of constipation amongFilipino children 1 month to 4 years of age is 12.2%. The riskfactors associated with constipation in children were familyhistory of constipation, family history of allergy, no fruit intake,no vegetable intake, irregular toilet use and no toilet training.On the other hand the risk factors identified in infants werefamilial history of constipation and gastrointestinal illness.[Keywords] Constipation304
P2-103 Gastroenterology P2-104 GastroenterologyZINC AND PROBIOTICSUPPLEMENTATION FOR PEDIATRICINPATIENTS WITH DIARRHEA IN ANINDONESIA DISTRICT GENERALOUTCOME OF AN INTERDISCIPLINARYFEEDING REHABILITATION PROGRAM FORCHILDREN WITH NEURODEVELOPMENTALDISABILITIESHOSPITALSiti Chasanah 1 , Ferri Widodo 2 , Diana Lyrawati 1,2 ,Nurcahyo Budi Santoso 31 Laboratory of Pharmacy, Faculty of Medicine, Brawijaya University –Saiful Anwar Hospital, Malang, Indonesia 2 Study Program of Pharmacy, Faculty of Medicine, Brawijaya University,Malang, Indonesia; 3 Department of Pediatrics, Division of Infection,Faculty of Medicine, Brawijaya University – Saiful Anwar Hospital,Malang, IndonesiaBACKGROUND: Zinc and probiotic supplementation(Zn-probiotic) has been shown to accelerate recoveryfrom diarrhea in children in many developing countries,yet their efficacy in children in Indonesia is uncertain.Despite the recommendation of WHO/UNICEF andMinistry of Health Republic of Indonesia for use of zinc,it remains excluded from list of drugs covered by nationalhealth insurance (Askes/SKTM/Jamkesmas).OBJECTIVE: This study aimed at evaluatingsupplementation of zinc-probiotic, to explore contributingfactor to non-adherence, regimen of therapy andassociated clinical outcomes in the management ofdiarrhea in pediatric inpatients.METHOD: A prospective observational study wasconducted in High Nursing Dependency Unit, one ofpediatric wards at Saiful Anwar Hospital, Malang,Indonesia. Data were collected from medical record anddirect observation of all patients with diarrheahospitalized during February to December 2009.RESULTS: From 41 patients, 60% (28 cases) wasprescribed for Zn and probiotic supplementation. Of thesepatients, adherence was observed in 59% patients;whereas the rest did not adhere to therapy due to palatableor difficulties in consuming the Zn formulated as tabletand financial resources of the patients. Supplementationof Zn-probiotics associated with recovery in 60% of thepatients compared to 40% in those who did not receiveZn-probiotic. Other than Zn and probiotic, in somepatients, antibiotics were also used concurrently. Ouranalysis showed that the use of antibiotics did notsignificantly influence time needed for recovery ofdiarrhea; in both groups with or without antibioticsdiarrhea lessen within 1-5 days.CONCLUSION: Our observation indicated thatprescription for supplementation of Zn-probiotic forchildren with diarrhea has reached 60% of the patients,and associated with higher proportion of patientsrecovered from diarrhea. Further studies are warrantedto validated these results to support recommendation ofZn-probiotic being included in the national scheme ofhealth insurance and adjustment of Zn dosage form toimprove adherence.[Keywords]zinc,probiotic,diarrhea,pediatric,high nursedependencyRosanna Ming Sum Wong, Sophelia ChanDepartment of Paediatrics and Adolescent MedicineDuchess of Kent Children’s Hospital and Queen Mary HospitalThe University of Hong Kong, Hong KongWe report the outcomes of an interdisciplinary program inHong Kong which was established in 2008 for themanagement of feeding difficulties in children withneurodevelopmental disabilities. The program was run bya feeding team which included developmentalpaediatrician and neurologist, gastroenterologist,paediatric surgeon, speech therapist, occupationaltherapist, dietitian and nurse specialist. This was a singlecentre longitudinal prospective cohort study designed toinvestigate the outcomes of the feeding rehabilitationprogram. Forty-nine patients were assessed and enrolledfrom March 2008 to March 2009. Thirty-one percent ofthe children had cerebral palsy and 27% hadchromosomal or syndromal disorders. Other diagnosesincluded prematurity, global developmental delay, brainmalformation, neuromuscular disease, traumatic braininjury and brain tumor. Outcome measures includedgrowth as measured by z score for body weight, change inmode of feeding and episodes of aspiration pneumoniarequiring medical attention. The patients were assessed atbaseline, 3-6 months and 6-12 months after intervention.Types of interventions included change in mode offeeding, oromotor therapy, treatment of gastro-esophagealreflux and dietary modification. Six patients hadgastrostomy +/- fundoplication performed and 5 patientswere weaned from nasogastric or orogastric tube feedingto full oral feeding during the period. Statisticalsignificant improvement in Z score for body weight anddecreased episodes of aspiration pneumonia wereobserved.305
Page 1 and 2: ABSTRACT OF POSTER PRESENTATION(APR
Page 3 and 4: P2-005 Allergy/Immunology/Rheumatol
Page 23 and 24: P2-045 Neuropsychiatry (Neurology)
Page 40 and 41: P2-079 Nephrology P2-080 Nephrology
Page 46 and 47: P2-091 Nephrology P2-092 Gastroente
Page 48 and 49: P2-095 Gastroenterology P2-096 Gast
Page 56 and 57: P2-113 Endocrinology P2-114 Endocri
Page 62 and 63: P2-125 Medical Genetics/Metabolism
Page 68 and 69: P2-138 General Pediatrics P2-139 Ge
Page 78 and 79: P2-158 Neonatology P2-159 Neonatolo
Page 86: P2-175 Neonatology P2-176 Neonatolo

ABSTRACT OF POSTER PRESENTATION (APRIL 17, SATURDAY)

Create successful ePaper yourself

Delete template?

Save as template?