ABSTRACT OF POSTER PRESENTATION (APRIL 17, SATURDAY)

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P2-015 Allergy/Immunology/Rheumatology P2-016 Allergy/Immunology/RheumatologyROLE OF HLA-DRB1 ALLELICPOLYMORPHISM IN JUVENILE IDIOPATHICARTHRITIS IN CHINESE PATIENTSZENG HUA SONG**,WU JUAN***Department of Allergy, Immunology and Rheumatology, Guangzhouchildren’s hospital, Guangzhou, China, 510120A PILOT STUDY EVALUATING THETHERAPEUTIC EFFECTS AND SAFETY OF ANORALLY ADMINISTERED EXTRACT OFDENDROBIUM HUOSHANENSE FOR SEVERERECALCITRANT ATOPIC DERMATITIS INCHILDRENOBJECTIVE: To investigate the predisposing allelesof HLA - DRB1 genes in Juvenile idiopathic arthritis.METHODS: Polymerase chain reaction - specificsequence primers (PCR - SSP) method was used totype HLA -DRB1 subregion in 94 cases of patientswith Juvenile idiopathic arthritis and matched controlsubjects of Han nationality in Guangdong province.RESULTS: The frequency of HLA-DRB1*08(Pc:0.0049、OR:2.20) allele in patients with Juvenileidiopathic arthritis was significantly higher than thatin controls, and the frequency of HLA-DRB1*12(Pc:0.0488、OR:0.60)allele was significantly lowerthan that in controls. According to the diffenrent JIAisoforms, We found that in systemic JIA subset(Pc:0.0130、OR:2.37)and polyarthritis JIA subset(Pc:0.0222、OR:2.73),the allete HLA-DRB1*08were expressed most commonly,In systemic JIAsubset(Pc:0.0293、OR:0.39)and oligoarthritis subset(Pc:0.0352、OR:0.15),the allete HLA-DRB1*15was expressed lower frenquent than the control,whatever, in polyarthritis JIA the alleteHLA-DRB1*13(Pc:0.0214、OR:2.74) was expressedhigher frenquent than the control.CONCLUSION: HLA-DRB1*08 may be thesusceptible alleles of Juvenile idiopathic arthritis inHan Guangdong Chinese, HLA-DRB1*12 may bethe protective alleles of Juvenile idiopathic arthritisin Han Guangdong Chinese. The HLA-DRB1*08was the susceptible alleles in systemic JIA andpolyarthrits.HLA-DRB1*13 was also the susceptiblealleles in systemic JIA, HLA-DRB1*15 was theprotective alleles in systemic JIA and oligoarthritis.[Keywords]Juvenile arthritis idiopathic; HLA - DRB1; PCR - SSP;isoformTsung-Han Li, Chun-Jen Chen, Chiao-Wei Lo, Chun-MingChen, Hao-I Cheng, Keh-Gong WuDepartment of Pediatrics, Taipei Veterans General Hospital and NationalYang-Ming University, Taipei, Taiwan.BACKGROUND: Atopic dermatitis (AD) is a commoninflammatory skin disorder for which few safe andeffective systemic treatments are available.OBJECTIVES: To test the safety and effectiveness ofextract of Dendrobium huoshanense for the treatment ofsevere recalcitrant AD in children in a pilot, case seriesstudy.PATIENTS: Twenty-seven patients with AD who hadnot responded to topical therapy were enrolled.METHODS: Patients were treated with crude extractderived from Dendrobium huoshanense (1000 mg pertablet) twice daily (total 2000 mg per day) (body weight
P2-017 Allergy/Immunology/Rheumatology P2-018 Allergy/Immunology/RheumatologyTHE ASSOCIATION OF SKIN TESTREACTIVITY TO COW`S MILK PROTEINJUNVENILE SCLERODERMA-EXPERIENCE INONE INSTITUTIONAND/OR SOY PROTEIN WITH THESEVERITY OF ATOPIC DERMATITIS AMONGINFANTS AGED 1-6 MONTHS OLDMelanie Yagdulas GavinoPediatrics, De La Salle University Health Sciences Institute, PhilippinesOBJECTIVE: To determine the association of skin testreactivity to Cow’s Milk Protein (CMP) and/or Soy Protein(SP) with Atopic Dermatitis (AD) in infants aged 1 to 6months old.STUDY DESIGN: Hybrid Design, specifically aFollow-up Prevalence Study.SETTING: Cavite, Philippines.PARTICIPANTS: Infants aged 1 to 6 months olddiagnosed with AD using the Hanifin and Rajka criteria.OUTCOME MEASURE: Severity of atopic dermatitisusing Scoring Atopic Dermatitis.METHODS: All infants who fulfilled the diagnosticcriteria of AD underwent allergy skin prick test (SPT) toCMP, SP, a positive and a negative control. Severity of ADwas assessed using the SCORAD index. Statistical analysiswas performed using SPSSPC+ and Epi-Info softwares.Chi-square was used to determine if there was statisticallysignificant association between skin test reactivity to CMPand/or SP and the severity of atopic dermatitis, familyhistory of atopy and feeding. T-test was used todetermine the association between skin test reactivity andMean SCORAD. Spearman`s rank correlation coefficientwas computed to determine the correlation of severity ofatopic dermatitis with the number of positive skin pricktest results.RESULTS: There were a total of 54 participants. Mostwere males with a mean age of 3 months. More than 2/3was with mild to moderate atopic dermatitis (77.8%).Majority were positive to skin prick test (66.7%). Theproportion of skin test reactivity to CMP and SP amonginfants with AD was at 48.2% and 50%, respectively.There was a significant association between the skin testreactivity to CMP and/or SP and the severity of AD.Statistical analysis showed that there was a significantassociation between skin test reactivity and family historyof AD. There was no association between skin testreactivity and whether the patient is on pure milk formulaor mixed feeding. A positive direct relationship betweenseverity of AD and number of skin test reactivity was alsonoted.CONCLUSION: Although AD is viewed by many as aminor dermatologic problem, the stress that it poses to thefamily and economy cannot be ignored. The resultsshowed a higher proportion of positive skin test reactivityto CMP and SP among AD infants as compared tointernational studies. There was a significant associationbetween skin test reactivity to CMP and/or SP and severityof AD. This study supports the advocacy of the AAPregarding the importance of breastfeeding.[Keywords]atopic dermatitis, skin test reactivity, Scoring AtopicDermatitis (SCORAD)Chia-Yi Lo, Shyh-Dar Shyur, Szu-Hung Chu, Li-HsinHuang, Yu-Hsuan Kao, Wei-Te Lei, Chieh-Han Cheng,Kuo-Hsi Lee, Chen-Kuan Chen, Ling-ChunLiuDepartment of Pediatrics, Mackay Memorial Hospital, Taipei, TaiwanOBJECTIVE: Scleroderma is a chronic connective tissuedisease characterized by sclerodermatous skin changes andwidespread abnormalities of the viscera, which are rare inpediatric age group. In this study, we retrospectivelyreviewed 22 pediatric patients with systemic and localizedscleroderma.MATERIALS AND METHODS: Twenty-two patientsdiagnosed as systemic and localized scleroderma wereenrolled in our study, from March 1993 to September 2009in Department of Pediatrics, Mackay Memorial Hospital,Taipei, Taiwan. The diagnosis is made based on the criteriaof American College of Rheumatology and clinicalmanifestations of hard skin involvement. Data extractedfrom the records includes gender, age at onset, age atdiagnosis, clinical manifestations, laboratory data, familyhistory, trauma history, treatment, and the outcome.RESULTS: Three patients had systemic scleroderma.Nineteen patients had localized scleroderma. The ratio ofLS and SSc is 6.3:1. There were 15 females and 7 males(female to male ratio 2.1:1). The mean age at diagnosis was8.90±3.41 years. The mean age at onset was 6.23±2.98years. Antinuclear antibodies were positive in 15 at titers of40X to 10240X; 2 had a nucleolar pattern, 7 had a speckledpattern, 4 had a homogenous pattern, and 2 had aspeckled-to- homogeneous pattern. Tests for anti-SCL70antibodies were positive in only 1 patient with systemicscleroderma. Tests for anti-double-stranded-DNA were allnegative. Serum levels of rheumatoid factor ranged from
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ABSTRACT OF POSTER PRESENTATION (APRIL 17, SATURDAY)

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