GastroCH4ECK, MEC and Quintron Comparison - Bedfont Scientific

Reading Comparison Study to Evaluate the Agreement Between 3 combined Hydrogen and MethaneBreath AnalysersAnalysers UsedPersons PresentManufacturerModelNameCompanyBedfont Scientific LtdMedical Electronic ConstuctionQuintronGastroCH4ECKLactotest 202Breath TrackerDr Hugo Van DievelAyodelle AdigunJason SmithHiedi MerckxPeter MeertUniversity Hospital GentBedfont Scientific LtdBedfont Scientific LtdBoucart MedicalMedical Electronic ConstructionMethod3 patients were selcted by Dr Hugo Van Dievel to be tested for uplift in H2 and CH4 readings following ingestion of50g of lactose solution. The patients will give a baseline breath sample every 20 minutes for 3 hours after ingestingthe lactose dosage using the manufacturers breath collection bags. These samples are then analysed on eachdevice and the readings compared to show agreement.ConclusionThe CH4 readings were agreeable in trend between the GastroCH4ECK and Breath Tracker but the Lactotest 202was not and appeared quite erratic. With patient 1 the Lactotest 202 appeared to present a false positive reading.The H2 readings were agreeable in trend between the GastroCH4ECK, Breath Tracker and Lactotest 202.Note - All three analysers were calibrated according to the manufacturer's instructions using the three differentmanufacturer's gas. Also readings were taken from 3 different breath samples on each patient collection. This couldtherefore potentially cause some reading differences with regard to the PPM result.Patient 1 - MaleAnalyser H2 CH4 O2/CO2% Correction FactorCorrectedH2CorrectedCH4GastroCH4ECK 3 1 16.1 1.45 4 120 2 1 18.1 2.33 4 240 3 1 17.4 2 6 260 2 0 16.7 1.66 3 080 1 1 18.1 2.33 2 2100 2 1 17.8 2.25 4 2120 2 1 16 1.42 2 1140 2 1 16.5 1.59 3 1160 2 1 17.6 2.12 4 2Lactotest 202 0 0 3.14 0 020 4 4 3.34 4 440 2 4 4.08 2 460 1 5 4.83 1 580 1 8 4.78 1 9100 1 13 4.01 1 17120 1 8 4.61 1 9140 1 2 4.78 1 2160 2 2 4.36 2 2Quintron 0 0 3.6 0 020 3 0 3.4 1.6 5 040 2 0 3.5 1.5 3 060 1 0 4.2 1.3 1 080 0 0 3.6 1.5 0 0100 0 0 3.7 1.5 0 0120 0 0 4 1.4 0 0140 0 0 4.4 1.2 0 0160 0 0 4 1.7 0 0

Patient 2 - FemaleAnalyser H2 CH4 O2/CO2% Correction FactorCorrectedH2CorrectedCH4GastroCH4ECK 2 1 15.4 1.27 2 120 2 1 16.9 1.75 3 140 3 1 16.7 1.66 4 160 4 1 16.7 1.66 6 180 5 1 16.8 1.7 8 1100 6 1 17 1.79 10 1120 6 1 16.1 1.45 8 1140 8 1 14.9 9 1160 6 1 15.9 1.4 8 1Lactotest 202 1 1 3.52 1 120 1 4 3.79 1 540 4 4 3.91 5 560 4 3 3.83 5 480 4 3 3.97 5 4100 5 2 3.97 7 2120 6 1 3.92 8 1140 5 0 3.36 8 0160 2 2 3.06 3 3Quintron 0 0 4.1 0 020 0 0 2.8 1.2 0 040 0 0 3 1.8 0 060 2 0 3.3 3.3 3 080 2 0 3.4 1.6 3 0100 2 0 3.2 1.7 3 0120 2 0 3.1 1.8 4 0140 4 0 3.8 1.4 6 0160 2 0 3.4 1.6 3 0Patient 3 - MaleAnalyser H2 CH4 O2/CO2% Correction FactorCorrectedH2CorrectedCH4GastroCH4ECK 1 20 16.2 1.48 1 2920 2 28 14.3 1.06 2 2940 2 22 15.8 1.37 2 3060 1 17 16.2 1.48 1 2580 1 22 16.3 1.52 1 33100 0 18 16.2 1.48 0 26120 1 22 16.1 1.45 1 31140 0 20 14.7 1.12 0 22Lactotest 202 0 19 4.23 0 2420 2 26 4.5 2 3140 1 24 4.8 1 2760 1 28 5.72 0 2680 0 17 4.22 0 22100 0 14 4.06 0 18120 0 15 3.33 0 20140Quintron2040 0 16 4.1 1.3 0 2160 0 11 3.7 1.5 0 1680 0 14 3.4 1.6 0 23100 0 9 3.1 1.8 0 16120 0 13 3.5 1.6 0 20140 0 8 3.2 1.7 0 14

Patient 1181614PPM1210864GastroCH4ECKH2GastroCH4ECKCH4Lactotest 202H2Lactotest 202CH4QintronH2QuintronCH4201 2 3 4 5 6 7 8 9Test

Patient 21210PPM864GastroCH4ECKH2GastroCH4ECKCH4MECH2MECCH4QintronH2QuintronCH4201 2 3 4 5 6 7 8 9Test

Patient 33530PPM25201510GastroCH4ECKH2GastroCH4ECKCH4MECH2MECCH4QintronH2QuintronCH4501 2 3 4 5 6 7 8Test