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Surgical Pathology and CurrentMolec
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Barrett’s EsophagusDefinition•
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Barrett’s EsophagusEpithelial Typ
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Multilayered Epithelium
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Short (Ultrashort) BE vs.Chronic Ca
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Esophageal versus Cardia___________
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Barrett’s Dysplasia/CarcinomaRisk
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Barrett’s Dysplasia/CarcinomaRisk
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DysplasiaPathologic Features1. Gros
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Non-Recommended Terms“Atypia”
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Barrett’s-related DysplasiaIntero
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Adjunctive TechniquesProliferation
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Esophagectomy forHigh-Grade Dysplas
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ACG guidelines for Surveillance in
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Management ConsiderationsSurveillan
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Molecular Basis ofBarrett’s Esoph
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Non-DysplasticBarrett’s Esophagus
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Aneuploidy Predicts Progressionin B
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p53 Gene Detection•17p loss of he
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17p LOH & Progressionin Barrett’s
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p53 “Positive” Immunostaining
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p53 Positive Barrett’s Indefinite
- Page 90 and 91: Detection of p16 Inactivationin Bar
- Page 92 and 93: Cyclin D1 Gene•Cyclin/CDK complex
- Page 94 and 95: Molecular Summary ofBarrett’s Eso
- Page 96 and 97: Molecular Summary ofBarrett’s Eso
- Page 98 and 99: Dysplasia in Crohn’s Disease• R
- Page 100 and 101: Dysplasia in Crohn’s Disease(Sige
- Page 102 and 103: Risk of Neoplasia in UC1. Dysplasia
- Page 104 and 105: Primary Sclerosing CholangitisRisk
- Page 129 and 130: UC-Associated DysplasiaInterobserve
- Page 131 and 132: Flat DysplasiaNatural History(Berns
- Page 133 and 134: Colectomy for Low Grade Dysplasia__
- Page 135: DALMAdenoma LikeSessile/Pedunculate
- Page 146 and 147: Adenoma vs Polypoid DysplasiaValue
- Page 148 and 149: Genetic Alterations inChronic ulcer
- Page 150 and 151: Is it possible to reliablydifferent
- Page 152 and 153: ______Feature CUC patients Non-CUCA
- Page 154 and 155: Rubin et al________________________
- Page 156: DALMAdenoma-likeNon-Adenoma-like(br
- Page 160 and 161: Genetic Progression inColitis-Assoc
- Page 162 and 163: Colitis-AssociatedVersus Sporadic N
- Page 164 and 165: Aneuploidy Associations inColitis-A
- Page 166 and 167: neuploidy Predicts Progressionin No
- Page 168 and 169: p53 inNegative/IndefiniteMucosa
- Page 170 and 171: Other Markers inColitis-Associated
- Page 172 and 173: Chromosomal Instability (CIN)in Col
- Page 174 and 175: Telomere Erosion inColitis-Associat
- Page 176 and 177: Fecal DNA Mutation Testing•High s
- Page 178 and 179: Squamous Dysplasia
- Page 180 and 181: Squamous dysplasiaclinical features
- Page 182: Pathologic features• Gross: eryth
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Squamous dysplasia vs reactiveFeatu
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Squamous dysplasia- treatmentDYSPLA
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Genetic Progression inEsophageal Sq
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p53 Immunostaining inEsophageal Squ
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Small Intestinal Metaplasia andDysp
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Mucous cell metaplasia• Feature o
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Small intestinal dysplasia• Crohn
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Gastric Metaplasia and Dysplasia
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Gastric carcinoma- risk factors•
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Intestinal metaplasiaclassification
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Gastric dysplasiaPadova classificat
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Gastric dysplasia-differentialdiagn
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Gastric DysplasiaManagementLOW GRAD
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Gastric hyperplastic polyps• Most
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Fundic gland polypsClinical feature
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Molecular Basis ofGastric Dysplasia
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p53 Alterations in GastricMetaplasi
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MSH2MSH3DNA mismatchmismatch bindin
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Mismatch Repair Gene Immunohistoche
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MLH1 Methylation inGastric Metaplas
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Fundic Gland Polyps•Occur in two
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Genetic Predictors of Dysplasiain F