Barrett's Esophagus - BPA Pathology

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Chromosomal Instability (CIN)in Colitis-Associated Neoplasia•Dual color FISH chromosomes 8, 11, 17, 18•Histologically negative rectal biopsies•CIN present in:•10% non-IBD control cells•22% negative colitis cells (dysplasia orcancer elsewhere)•P
Telomere Erosion inColitis-Associated Neoplasia•“Cap” on ends of chromosomes•Maintain genome stability•Loss associated with senescence•Accelerated shortening with:•rapid cell turnover•oxidative injury
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Surgical Pathology and CurrentMolec
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Barrett’s EsophagusDefinition•
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Barrett’s EsophagusEpithelial Typ
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Multilayered Epithelium
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Short (Ultrashort) BE vs.Chronic Ca
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Esophageal versus Cardia___________
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Barrett’s Dysplasia/CarcinomaRisk
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Barrett’s Dysplasia/CarcinomaRisk
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DysplasiaPathologic Features1. Gros
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Non-Recommended Terms“Atypia”
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Barrett’s-related DysplasiaIntero
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Adjunctive TechniquesProliferation
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Esophagectomy forHigh-Grade Dysplas
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ACG guidelines for Surveillance in
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Management ConsiderationsSurveillan
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Molecular Basis ofBarrett’s Esoph
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Non-DysplasticBarrett’s Esophagus
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Aneuploidy Predicts Progressionin B
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p53 Gene Detection•17p loss of he
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17p LOH & Progressionin Barrett’s
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p53 “Positive” Immunostaining
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p53 Positive Barrett’s Indefinite
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Detection of p16 Inactivationin Bar
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Cyclin D1 Gene•Cyclin/CDK complex
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Molecular Summary ofBarrett’s Eso
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Molecular Summary ofBarrett’s Eso
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Dysplasia in Crohn’s Disease• R
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Dysplasia in Crohn’s Disease(Sige
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Risk of Neoplasia in UC1. Dysplasia
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Primary Sclerosing CholangitisRisk
Page 129 and 130: UC-Associated DysplasiaInterobserve
Page 131 and 132: Flat DysplasiaNatural History(Berns
Page 133 and 134: Colectomy for Low Grade Dysplasia__
Page 135: DALMAdenoma LikeSessile/Pedunculate
Page 140 and 141: Adenoma vs Polypoid Dysplasia1. Mor
Page 146 and 147: Adenoma vs Polypoid DysplasiaValue
Page 148 and 149: Genetic Alterations inChronic ulcer
Page 150 and 151: Is it possible to reliablydifferent
Page 152 and 153: ______Feature CUC patients Non-CUCA
Page 154 and 155: Rubin et al________________________
Page 156: DALMAdenoma-likeNon-Adenoma-like(br
Page 160 and 161: Genetic Progression inColitis-Assoc
Page 162 and 163: Colitis-AssociatedVersus Sporadic N
Page 164 and 165: Aneuploidy Associations inColitis-A
Page 166 and 167: neuploidy Predicts Progressionin No
Page 168 and 169: p53 inNegative/IndefiniteMucosa
Page 170 and 171: Other Markers inColitis-Associated
Page 174 and 175: Telomere Erosion inColitis-Associat
Page 176 and 177: Fecal DNA Mutation Testing•High s
Page 178 and 179: Squamous Dysplasia
Page 180 and 181: Squamous dysplasiaclinical features
Page 182: Pathologic features• Gross: eryth
Page 198: Squamous dysplasia vs reactiveFeatu
Page 209 and 210: Squamous dysplasia- treatmentDYSPLA
Page 211 and 212: Genetic Progression inEsophageal Sq
Page 213 and 214: p53 Immunostaining inEsophageal Squ
Page 215 and 216: Small Intestinal Metaplasia andDysp
Page 217: Mucous cell metaplasia• Feature o
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Small intestinal dysplasia• Crohn
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Gastric Metaplasia and Dysplasia
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Gastric carcinomarisk factors•
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Intestinal metaplasiaclassification
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Gastric dysplasiaPadova classificat
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Gastric dysplasia-differentialdiagn
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Gastric DysplasiaManagementLOW GRAD
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Gastric hyperplastic polyps• Most
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Fundic gland polypsClinical feature
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Molecular Basis ofGastric Dysplasia
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p53 Alterations in GastricMetaplasi
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MSH2MSH3DNA mismatchmismatch bindin
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Mismatch Repair Gene Immunohistoche
Page 296 and 297:
MLH1 Methylation inGastric Metaplas
Page 298 and 299:
Fundic Gland Polyps•Occur in two
Page 300 and 301:
Genetic Predictors of Dysplasiain F
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